Antithrombotic Management in AF Patients Following Percutaneous Coronary Intervention: A European Perspective

Greco, Antonio; Laudani, Claudio; Rochira, Carla; Capodanno, Davide

doi:10.15420/icr.2021.30

Cited by 6 publications

(1 citation statement)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four RCTs investigated DAT with clopidogrel and a direct oral anticoagulant (DOAC; i.e., rivaroxaban, dabigatran, apixaban, edoxaban) following a short course of triple therapy (randomization time from PCI from zero to 14 days across trials) [ 91 ]. The PIONEER AF-PCI showed a reduction in one-year clinically relevant bleeding with DAT (rivaroxaban 15 mg once daily plus a

-inhibitor) as compared to VKA-based triple therapy without a significant difference in terms of ischemic outcomes [ 92 ].…”

Section: -Inhibitor Monotherapy In Patients Requiring Oral Anticoagu...mentioning

confidence: 99%

P2Y12 Inhibitor Monotherapy: Considerations for Acute and Long-Term Secondary Prevention Post-PCI

Greco¹,

Mauro²,

Capodanno³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Following percutaneous coronary intervention (PCI), an initial course of dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor (P2Y12-i) is recommended to minimize the risk of thrombotic complications. After the initial period of DAPT, antiplatelet monotherapy, usually consisting of aspirin, is administered for long-term secondary prevention. However, over the last few years there has been accruing evidence on P2Y12-i monotherapy, both in the acute (i.e., post-PCI; after a brief period of DAPT, transitioning to monotherapy before six or 12 months in patients with chronic or acute coronary syndrome, respectively) and chronic (i.e., long-term secondary prevention; after completion of six or 12 months of DAPT, in patients with chronic or acute coronary syndrome, respectively) settings. In aggregate, most studies of short DAPT with transition to P2Y12-i monotherapy showed a reduced risk of bleeding complications, without any significant increase in ischemic events as compared to standard DAPT. On the other hand, the evidence on long-term P2Y12-i monotherapy is scarce, but results from a randomized trial showed that clopidogrel monotherapy outperformed aspirin monotherapy in terms of net benefit, ischemic events and bleeding. Antiplatelet therapy is also recommended for patients undergoing PCI and with an established indication for long-term oral anticoagulation (OAC). In this scenario, a brief period of triple therapy (i.e., aspirin, P2Y12-i and OAC) is followed by a course of dual antithrombotic therapy (usually with P2Y12-i and OAC) and ultimately by lifelong OAC alone. European and American guidelines have been recently updated to provide new recommendations on antithrombotic therapy, including the endorsement of P2Y12-i monotherapy in different settings. However, some areas of uncertainty still remain and further randomized investigations are ongoing to fulfil current gaps in knowledge. In this review, we assess the current knowledge and evidence on P2Y12-i monotherapy for the early and long-term secondary prevention in patients undergoing PCI, and explore upcoming research and future directions in the field.

show abstract

-inhibitor) as compared to VKA-based triple therapy without a significant difference in terms of ischemic outcomes [ 92 ].…”

Section: -Inhibitor Monotherapy In Patients Requiring Oral Anticoagu...mentioning

confidence: 99%