Antithrombotic Therapy for Peripheral Artery Disease in 2018

Hess, Connie N.; Hiatt, William R.

doi:10.1001/jama.2018.5422

Cited by 30 publications

(15 citation statements)

References 12 publications

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“…This treatment can reduce the relapse rate in post PTCA patients, hopefully, close to 0%. [16,17]. The recurrent cardiac events after CABG can also be prevented [18].…”

Section: Discussionmentioning

confidence: 99%

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A Cure of Coronary Artery Disease by Removing Atheromatous Plaques from Coronary Arteries in a Diabetic Patient

Ahmad¹

2018

J Diabetes Metab

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Objective: A cure for coronary artery disease is desperately needed as more people die of this disease. The coronary disease can be cured by removal of all atheromatous plaques by pharmacological intervention. This pharmacological treatment can also prevent acute myocardial infarction, unstable angina, chronic stable angina, CABG, PTCA and cardiac death. Case presentation:The patient is 75 years old, who had CABG and PTCA and suffered from daily chest pain which was relieved with nitroglycerin. Also had pain in both upper arms and both forearm several hours a day and this arm pain did not respond to nitroglycerin. She suffered with coughing wheezing and shortness of breath. No treatment helped her. Chest X-Ray showed cardiomegaly. EKG showed right bundle branch block. The coronary angiogram of 2013 showed advanced obstructive disease involving LAD and left circumflex artery with disease of the grafts. The right coronary artery was completely blocked with partially blocked graft. The patient was given standard treatment of coronary artery disease and for other conditions she suffered. The medications given for the removal of atheroma from coronary arteries were Carvedilol, Metformin, statin and Evolocumab. The patient was symptom free in 3 months. A repeat coronary angiogram in 2018 showed that LAD, left circumflex and right coronary arteries and their branches had no disease and no obstructive lesion. The graft to right to the right coronary artery was open and other grafts remained unchanged. Conclusions:1) The atherosclerotic coronary artery disease can be cured. 2) Primary and secondary prevention of coronary artery disease can be achieved. 3) Intractable angina can be cured. 4) Stroke and TIA can be prevented. 5) Totally occluded coronary arteries can be opened.

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“…This treatment can reduce the relapse rate in post PTCA patients, hopefully, close to 0%. [16,17]. The recurrent cardiac events after CABG can also be prevented [18].…”

Section: Discussionmentioning

confidence: 99%

“…The strokes and TIA due to thrombotic episodes can be prevented or their incidence can be reduced [14]. The peripheral vascular disease can probably, also be treated [16].…”

Section: Discussionmentioning

confidence: 99%

A Cure of Coronary Artery Disease by Removing Atheromatous Plaques from Coronary Arteries in a Diabetic Patient

Ahmad¹

2018

J Diabetes Metab

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“…Complications of heart disease [14][15][16][17][18][19][20][21][22][23][24][25] Heart failure One of the most common complications of heart disease, heart failure occurs when heart can't pump enough blood to meet body's needs. Heart failure can result from many forms of heart disease, including heart defects, cardiovascular disease, valvular heart disease, heart infections or cardiomyopathy.…”

Section: Tablementioning

confidence: 99%

Natural Foods and Indian herbs of cardiovascular interest

Mohiuddin¹

2019

PPIJ

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Since the start of human development, herbs have been an essential piece of society, esteemed for both their culinary and medicinal properties. Cardiovascular malady is the main executioner in the United States. Diet and way of life assume an imperative job in avoiding and switching heart infection, and certain herbs and supplements can help in bringing down hazard for heart ailment and treat heart conditions. Contrasted and customary prescriptions, herbal drugs don't require clinical investigations previously their showcasing or formal endorsement from administrative organizations, and thus their viability and wellbeing are once in a while demonstrated. Herbal medications have been utilized in patients with congestive heart disappointment, systolic hypertension, angina pectoris, atherosclerosis, cerebral inadequacy, venous deficiency, and arrhythmia, CHF, since hundreds of years. Be that as it may, numerous herbal cures utilized today have not experienced cautious logical appraisal, and some can possibly make genuine lethal impacts and real medication tranquilize cooperation's. In spite of the greater part of these herbs demonstrating an impact on organic components identified with the cardiovascular system, information on their clinical impacts are inadequate. Conceivably applicable reactions, including expanded danger of medication connections, are portrayed, and the likelihood of tainting or substitution with different meds speaks to a worry. Doctors ought to dependably evaluate the utilization of herbal meds with patients and talk about the conceivable advantages and symptoms with them. Multidisciplinary explore is as yet required to misuse the tremendous capability of these plants. Potential synergistic and unfriendly reactions of herb-medicate communications additionally should be considered. These methodologies will help in setting up them as solutions for cardiovascular sicknesses and incorporating them in the standard of healthcare system. In spite of the fact that it has for quite some time been demonstrated that nutrient D, ascorbic acid, and nutrient B12 are the way to treating unending ailments, including CVDs. Various regular carotenoids are available in new foods grown from the ground, and some have been concentrated widely in the counteractive action of coronary heart illness (CHD).

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“…Despite significant advances, embolic and thrombotic events (such as ischemic stroke, myocardial infarction, deep venous thrombosis, pulmonary embolism, and peripheral arterial disease) continue to be major causes of morbidity and mortality, worldwide. [1][2][3][4][5] Considering stroke in the U.S. alone, there are over 795,000 cases annually, with someone having a stroke on average every 40 s. Approximately 87% of strokes are ischemic and 13% hemorrhagic, with stroke ranking as the #5 cause of death, and a major cause of disability, dementia, and depression, costing more than 34 billion dollars annually. Heart disease is the #1 cause of death in the U.S., with the majority of cases being attributed to ischemic coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

<p>An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis</p>

Pernal¹,

Willis²,

Sabo³

et al. 2020

IJN

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Background: Thrombotic events continue to be a major cause of morbidity and mortality worldwide. Tissue plasminogen activator (tPA) is used for the treatment of acute ischemic stroke and other thrombotic disorders. Use of tPA is limited by its narrow therapeutic time window, hemorrhagic complications, and insufficient delivery to the location of the thrombus. Magnetic nanoparticles (MNPs) have been proposed for targeting tPA delivery. It would be advantageous to develop an improved in vitro model of clot formation, to screen thrombolytic therapies that could be enhanced by addition of MNPs, and to test magnetic drug targeting at human-sized distances. Methods: We utilized commercially available blood and endothelial cells to construct 1/8th inch (and larger) biomimetic vascular channels in acrylic trays. MNP clusters were moved at a distance by a rotating permanent magnet and moved along the channels by surface walking. The effect of different transport media on MNP velocity was studied using video photography. MNPs with and without tPA were analyzed to determine their velocities in the channels, and their fibrinolytic effect in wells and the trays. Results: MNP clusters could be moved through fluids including blood, at human-sized distances, down straight or branched channels, using the rotating permanent magnet. The greatest MNP velocity was closest to the magnet: 0.76 ± 0.03 cm/sec. In serum, the average MNP velocity was 0.10 ± 0.02 cm/sec. MNPs were found to enhance tPA delivery, and cause fibrinolysis in both static and dynamic studies. Fibrinolysis was observed to occur in 85% of the dynamic MNP + tPA experiments. Conclusion: MNPs hold great promise for use in augmenting delivery of tPA for the treatment of stroke and other thrombotic conditions. This model system facilitates side by side comparisons of MNP-facilitated drug delivery, at a human scale.

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Antithrombotic Therapy for Peripheral Artery Disease in 2018

Cited by 30 publications

References 12 publications

A Cure of Coronary Artery Disease by Removing Atheromatous Plaques from Coronary Arteries in a Diabetic Patient

A Cure of Coronary Artery Disease by Removing Atheromatous Plaques from Coronary Arteries in a Diabetic Patient

Natural Foods and Indian herbs of cardiovascular interest

<p>An in vitro Model System for Evaluating Remote Magnetic Nanoparticle Movement and Fibrinolysis</p>

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