Antithrombotic therapy in cardiac disease. An emerging approach based on pathogenesis and risk.

Stein, Bernardo; Fuster, Valentín; Halperin, Jonathan L.; Chesebro, James H.

doi:10.1161/01.cir.80.6.1501

Cited by 92 publications

(33 citation statements)

References 89 publications

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“…Based on pathogenesis and risk, 16 the risk of stroke is so low among the younger age group that it does not warrant the risk of anticoagulation therapy and the inconvenience of regular monitoring. Because the incidences of stroke, TIA, and myocardial infarction all increase after age 60 years, antithrombotic treatment should be considered if not contraindicated.…”

mentioning

confidence: 99%

Lone Atrial Fibrillation in Elderly Persons

Kopecky¹,

Gersh²,

McGoon³

et al. 1999

Arch Intern Med

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mentioning

confidence: 99%

Lone Atrial Fibrillation in Elderly Persons

Kopecky¹,

Gersh²,

McGoon³

et al. 1999

Arch Intern Med

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“…5 As the risk is continuous and cumulative, several thousand strokes occur every year in this patient population, and approximately 5% to 10% of them are fatal. 1,6 Several studies have tried to define the optimal range of anticoagulant treatment, optimizing between thromboembolic and bleeding complications. The results demonstrate a U-shaped curve with an optimal therapeutic level of INR 3.5.…”

mentioning

confidence: 99%

Mechanisms of Cerebrovascular Events as Assessed by Procoagulant Activity, Cerebral Microemboli, and Platelet Microparticles in Patients With Prosthetic Heart Valves

Geiser

Sturzenegger

Genewein

et al. 1998

Stroke

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Background and Purpose-Cerebrovascular events (CVE) in patients with prosthetic heart valves (PHV) have remained a severe and frequent complication despite oral anticoagulation with or without aspirin. We studied the possible pathophysiological involvement of platelet-derived microparticles (PMP) as a contributing factor for the increased incidence of CVE in patients with PHV. Methods-We compared in a retrospective, case-control study the clinical outcome after the implantation of the PHV with several different independent morphological and functional methods, including simultaneous transcranial Doppler monitoring of both middle cerebral arteries, PMP detection by flow cytometry with use of platelet-specific antibodies, coagulation markers, and determination of the procoagulant activity by Russell's viper venom time, a phospholipiddependent coagulation assay. Results-Eight

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“…The AF patients constituted a group at high risk for stroke 7 because all were aged older than 60 years and displayed one or more of the following conditions: left atrial enlargement, mitral or aortic valve stenosis or insufficiency, left ventricular hypertrophy, previous myocardial infarction, hypertension, thrombus, mitral valve prolapse or severe mitral annulus calcification, left ventricular wall motion abnormalities, and patent foramen ovale.…”

Section: Resultsmentioning

confidence: 99%

Cardiac sources of embolism in patients with pial artery infarcts and lacunar lesions.

Mast

Thompson

Völler

et al. 1994

Stroke

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Background and Purpose On the assumption that the majority of lacunes are caused by small-vessel diseases and that pial artery infarcts arise from cardioembolic or large-vessel diseases, 194 patients from the Berlin Cerebral Ischemia Data Bank with either lacunar or pial artery infarcts were analyzed for the frequency of cardiac sources of embolism. The primary hypothesis was that the frequency of cardiac sources of embolism is higher among pial artery infarct subjects.Methods The presence of cardiac sources of embolism was estimated by electrocardiographic and transthoracic and transesophageal echocardiographic studies. Cranial computed tomography scans were evaluated by two masked observers.Results The overall rate of cardiac sources of embolism did not differ significantly between the lacunar and the pial artery

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Antithrombotic therapy in cardiac disease. An emerging approach based on pathogenesis and risk.

Cited by 92 publications

References 89 publications

Lone Atrial Fibrillation in Elderly Persons

Lone Atrial Fibrillation in Elderly Persons

Mechanisms of Cerebrovascular Events as Assessed by Procoagulant Activity, Cerebral Microemboli, and Platelet Microparticles in Patients With Prosthetic Heart Valves

Cardiac sources of embolism in patients with pial artery infarcts and lacunar lesions.

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