Antithrombotics in the Emergency Room

Laforcade, Armelle de

doi:10.1002/9781119028994.ch71

Cited by 1 publication

(1 citation statement)

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“…In patients presenting for investigation of anaemia, it is desirable to identify the cause promptly to allow appropriate treatment to be initiated without extensive investigations. Although external bleeding can be quickly identified, internal haemorrhage can be more challenging to recognise and can cause profound blood loss (de Laforcade, 2017). In cases where gastrointestinal bleeding (GIB) is suspected, further investigation may include imaging and endoscopy to allow lesion visualisation and sampling (Tolbert, 2017).…”

Section: Introductionmentioning

confidence: 99%

Plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in dogs with anaemia

Safrany,

Holmes,

Adamantos

et al. 2023

Veterinary Medicine & Sci

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BackgroundGastrointestinal bleeding is a cause of anaemia in dogs. A reliable, non‐invasive biomarker to differentiate gastrointestinal bleeding from other causes of anaemia would be advantageous to direct clinical decisions in anaemic patients. Plasma urea:creatinine ratio is an accepted biomarker of upper gastrointestinal bleeding in human medicine.ObjectivesThe objective of this study was to evaluate plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in a population of dogs with anaemia.MethodsThis was a prospective cross‐sectional study of dogs with anaemia presenting to referral centres for the investigation of anaemia. Cases were categorised as having overt gastrointestinal bleeding (melena on presentation), occult gastrointestinal bleeding (historical and diagnostic findings consistent with gastrointestinal bleeding without melena at presentation) or anaemia of other cause (confident diagnosis other than gastrointestinal bleeding reached, normal diagnostic imaging of gastrointestinal tract). Urea:creatinine ratio at presentation was calculated by dividing urea (mg/dL) by creatinine (mg/dL).ResultsNinety‐five dogs were included. Plasma urea:creatinine ratio was not significantly different between dogs with overt or occult gastrointestinal bleeding or those with anaemia of other cause (median urea:creatinine ratio 25.8, 20.7 and 22.5, respectively). No significant difference in urea:creatinine ratio was found between dogs with upper and lower gastrointestinal bleeding (median urea:creatinine ratio 19.4 and 24.6, respectively).ConclusionsPlasma urea:creatinine ratio was not helpful in differentiating between dogs with anaemia resulting from gastrointestinal bleeding (overt or occult) and those with other causes of anaemia.

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Section: Introductionmentioning

confidence: 99%