Antithyroid Action of Ketoconazole: In-vitro Studies and Rat In-vivo Studies

Comby, Frédéric; Lagorce, Jean F.; Buxeraud, Jacques; Raby, C

doi:10.1111/j.2042-7158.1994.tb03719.x

Cited by 14 publications

(9 citation statements)

References 8 publications

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“…In preclinical studies, imidazoles, such as ketoconazole, have had antithyroid effects because of interference with iodine and thyroid peroxidase. 56 Nevertheless, administration of 200 to 600 mg/d of ketoconazole for 1 month did not affect thyroid function in euthyroid, hyperthyroid, or hypothyroid patients. 57,58 However, high-dose ketoconazole (1200 mg/d) may cause hypothyroidism.…”

Section: Antifungal Agentsmentioning

confidence: 88%

Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment

Lionakis

Samonis

Kontoyiannis

2008

Mayo Clinic Proceedings

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Systemic fungal infections are increasingly reported in immunocompromised patients with hematological malignancies, recipients of bone marrow and solid organ allografts, and patients with AIDS. Mycoses may infiltrate endocrine organs and adversely affect their function or produce metabolic complications, such as hypopituitarism, hyperthyroidism or hypothyroidism, pancreatitis, hypoadrenalism, hypogonadism, hypernatremia or hyponatremia, and hypercalcemia. Antifungal agents used for prophylaxis and/or treatment of mycoses also have adverse endocrine and metabolic effects, including hypoadrenalism, hypogonadism, hypoglycemia, dyslipidemia, hypernatremia, hypocalcemia, hyperphosphatemia, hyperkalemia or hypokalemia, and hypomagnesemia. Herein, we review how mycoses and conventional systemic antifungal treatment can affect the endocrine system and cause metabolic abnormalities. If clinicians are equipped with better knowledge of the endocrine and metabolic complications of fungal infections and antifungal therapy, they can more readily recognize them and favorably affect outcome.

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Section: Antifungal Agentsmentioning

confidence: 88%

Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment

Lionakis

Samonis

Kontoyiannis

2008

Mayo Clinic Proceedings

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“…Many other compounds have been found to affect thyroid hormone synthesis without interfering directly with thyroperoxidase (Gaitan 1988;Capen 1992;Gittoes & Franklyn 1995). In previous studies (Raby et al 1990;Comby et al 1994;Lagorce et al 1995) we showed that many drugs which inhibit thyroperoxidase form charge-transfer complexes with iodine. If these molecules, which are also strong electron-donors, accumulate in the thyroid gland they would tend to sequester iodine, thereby mimicking iodine de®ciency.…”

mentioning

confidence: 89%

Influence of Dietary Iodine on Drug-induced Hypothyroidism in the Rat

Beyssen

Lagorce

Clédat

et al. 1999

Journal of Pharmacy and Pharmacology

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Several compounds of pharmaceutical importance from a variety of chemical families, for example chlorpromazine and clomipramine, have been found to form charge-transfer complexes with iodine. We have investigated the influence of dietary iodine on thyroid-gland dysfunction induced by clomipramine, chlorpromazine or 2-thiazoline-2-thiol. We suggest that iodine is partly diverted from its metabolic pathway by complexation with drugs, and so the urinary concentration of iodide is increased. Both chlorpromazine and clomipramine, at doses which do not inhibit thyroperoxidase, enhanced urinary iodine excretion when dietary iodine was restricted (3.944+/-0.96 microg/day for chlorpromazine-tested rats, 3.43+/-1.33 microg/day for clomipramine-tested rats, compared with 2.34+/-0.11 microg/day in control rats). Concurrently, these pharmaceutical compounds increased the level of free thyroid-stimulating hormone (TSH) in comparison with controls and induced histological modifications in, and enlargement of, the thyroid gland. We have demonstrated that drug-induced loss of iodine in the urine was associated with antithyroid action when iodine intake was limited.

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“…Reduction of immunosuppression may prove helpful in disseminated disease. In preclinical studies, imidazoles, such as ketoconazole, have had antithyroid effects because of interference with iodine and thyroid peroxidase [9]. Nevertheless, administration of 200 to 600 mg/d of ketoconazole for 1 month did not affect thyroid function in euthyroid, hyperthyroid, or hypothyroid patients [3].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Suppurative Aspergillosis of the Thyroid

Thada

Prasad

Alva

et al. 2013

Case Reports in Otolaryngology

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Suppurative fungal infection of the thyroid is an extremely rare condition even more so in an immunocompetent patient. Fungal infections of the thyroid usually occur in immunocompromised patients with hematological malignancies, recipients of bone marrow and solid organ allografts on immunosuppression, and patients with AIDS. A 65-year-old male presented with swelling in the front of the neck for 2 years. Examination revealed a 4 × 4 cm non-tender, firm swelling of the right lobe of the thyroid. The patient was taken up for a subtotal thyroidectomy. Intra-operatively, an abscess cavity with pus was found in the right lobe of the thyroid. Histopathology revealed features of fungal abscess and staining demonstrated fungal hyphae characteristic of Aspergillus ssp.

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Antithyroid Action of Ketoconazole: In-vitro Studies and Rat In-vivo Studies

Cited by 14 publications

References 8 publications

Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment

Endocrine and Metabolic Manifestations of Invasive Fungal Infections and Systemic Antifungal Treatment

Influence of Dietary Iodine on Drug-induced Hypothyroidism in the Rat

A Rare Case of Suppurative Aspergillosis of the Thyroid

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