Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring

Tajiri, Junichi

doi:10.1001/archinte.150.3.621

Cited by 84 publications

(96 citation statements)

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“…Adverse reactions of ATD therapy In patients treated with methimazole, 0.3% developed agranulocytosis (70). The risks of drug-induced hepatitis, vasculitis and other adverse effects leading to discontinuation of ATDs were estimated at 1% (8).…”

Section: Data Used In the Modelmentioning

confidence: 99%

Managing toxic thyroid adenoma: a cost-effectiveness analysis

2002

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Objective: To examine the cost-effectiveness of therapeutic strategies for patients with toxic thyroid adenoma. Design: A decision analytic model was used to examine strategies, including thyroid lobectomy after a 3-month course of antithyroid drugs (ATDs), radioactive iodine (RAI), and lifelong ATDs followed by either RAI (ATD-RAI) or surgery (ATD-surgery) in patients suffering severe drug reactions. Methods: Outcomes were measured in quality-adjusted life years. Data on the prevalence of co-incident thyroid cancer, complications and treatment efficacies were derived from a systematic review of the literature (1966 -2000). Costs were examined from the health care system perspective. Costs and effectiveness were examined at their present values. Discounting (3% per year), variations of major cost components, and every variable for which disagreements exist among studies or expert opinion were examined by sensitivity analyses. Results: For a 40-year-old woman, surgery was both the most effective and the least costly strategy (e1391),while ATD-RAI cost the most (e5760). RAI was more effective than surgery if surgical mortality exceeded 0.6% (base-case 0.001%). RAI become less costly for women of more than 72 years (more than 66 in discounted analyses). For women of 85, ATD-RAI may be more effective than RAI and have an inexpensive marginal cost-effectiveness ratio (e4975) if lifelong follow-up results in no decrement in quality of life. Conclusions: Age, surgical mortality, therapeutic costs and patient preference must all be considered in choosing an appropriate therapy.

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Section: Data Used In the Modelmentioning

confidence: 99%

Managing toxic thyroid adenoma: a cost-effectiveness analysis

2002

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“…At the opposite side, some patients (< 20%) (not-well identified characteristics or profile) remained asymptomatic [1]. This supports the case for routine monitoring of blood counts in individuals receiving high-risk medications such as antithyroid drugs or ticlopidine [1,14]. This also supports a not consensual home management of such an event in certain patients (young, without medical history, with fever as the sole sign) [1].…”

Section: Clinical Manifestationsmentioning

confidence: 61%

Diagnosis and Management of Idiopathic Drug-Induced Severe Neutropenia and Agranulocytosis

Andrès¹,

Mourot-Cottet²,

Maloisel³

2017

SOJPPS

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“…Agranülositoz seçici olarak nöt-rofil sayısında belirgin azalma (sıklıkla 0.5x10 3 /mm 3 olması) ile birlikte ateş ve/veya enfeksiyonun işaretlerinin bulunmasıdır (7). PTU kullanımına bağlı agranülositozun insidansı %0.37'dir (8). Sıklıkla ilk 3 ay içerisinde görülme-sine rağmen daha geç dönemde de ortaya çıkabileceği bildirilmiştir (5).…”

Section: Discussionunclassified

Agranulocytosis due to propylthiouracil treatment: a case report

Sabuncu¹,

Eren²,

Kurnaz³

et al. 2015

Bakirkoy

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Agranulocytosis due to propylthiouracil treatment: a case report Propylthiouracil (PTU) is a commonly used anti-thyroid drug in the treatment of hyperthyroidism due to Graves disease. Life-threatening complications such as agranulocytosis may occur during the treatment of PTU. We present a case of hyperthyroidism due to Graves disease who was admitted with the typical signs of agranulocytosis at two months after the initiation of therapy and treated successfully with granulocyte colony stimulating factor.

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Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring

Cited by 84 publications

References 0 publications

Managing toxic thyroid adenoma: a cost-effectiveness analysis

Managing toxic thyroid adenoma: a cost-effectiveness analysis

Diagnosis and Management of Idiopathic Drug-Induced Severe Neutropenia and Agranulocytosis

Agranulocytosis due to propylthiouracil treatment: a case report

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