Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

Abstract

Objective To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group. Methods Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013-Feb 2014. Ninety cases of women with PCOS based on Rotterdam's criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques. Results Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (p \ 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (p \ 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (p \ 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (p \ 0.009). Conclusion The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.

Association between PCOS and autoimmune thyroid disease: a systematic review and meta-analysis

“…2015 ( 35 ) India Case-control Age-matched women without PCOS 55 23.27 ± 3.2 NA 21/37.72% 51 22.80 ± 4.4 NA 8/15.6% Anti-TPO and/or Anti-Tg positivity Higher prevalence of AITD in PCOS group ( P < 0.05) Menon et al . 2016 ( 36 ) India Case-control Age-matched women without PCOS 90 30.02 ± 8.51 24.6 ± 4.0 23/25% 90 31.4 ± 8.6 21.3 ± 2.8 5/5.6% Anti-TPO positivity Higher prevalence of AITD in PCOS group ( P < 0.05) Yu et al . 2016 ( 38 ) China Case-control Age and BMI-matched healthy women 100 27.4 ± 5.4 31.2 ± 8.3 25/25% 100 23.3 ± 4.1 29.2 ± 5.1 2/2% Anti-TPO and hypoechoic thyroid Higher prevalence of AITD in PCOS group ( P < 0.0001) Sinha ...…”

“…A summary of the main characteristics of the 13 studies included in the systematic review and meta-analysis is described in Table 1 . Seven studies focused on Asian populations: three were performed with Turkish women ( 32 , 33 , 34 ), three with women from India ( 35 , 36 , 37 ) and one with Chinese women ( 38 ). Four studies in Europe evaluated German ( 39 ), Italian ( 40 ), Bulgarian ( 41 ) and Slovakian ( 42 ) women.…”

“…AITD diagnosis was based on the criteria defined in each study. Regarding design, there were nine cross-sectional studies ( 32 , 33 , 34 , 37 , 39 , 40 , 41 , 42 , 43 ) and four case–control studies ( 35 , 36 , 38 , 44 )). Population size ranged from 22 to 175 patients, totaling 1210 women with PCOS and 987 healthy controls.…”

“…Mean BMI ranged from 24.6 to 34.8 kg/m 2 in PCOS and 21.3 to 29.2 kg/m 2 in comparison groups ( Table 1 ). NOS score was 9 in six studies ( 33 , 37 , 38 , 40 , 41 , 44 ), 8 in six studies ( 32 , 34 , 35 , 36 , 39 , 42 ) and 7 in one study ( 43 ) ( Table 2 ).…”

“…2016 ( 37 ) ★★★★ ★★ ★★★ 9 Sinha et al . 2017 ( 36 ) ★★★★ ★★ ★★★ 9 Karakose et al . 2017 ( 33 ) ★★★★ ★ ★★★ 8 Janssen et al .…”