Antitrypsin and Chronic Obstructive Pulmonary Disease among Japanese-American Men

Roberts, Albert; Kagan, Abraham; Rhoads, George G.; Pierce, John A.; Bruce, Robert M.

doi:10.1378/chest.72.4.489

Cited by 14 publications

(8 citation statements)

References 15 publications

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“…Figure 1 shows the patterns of various Pi phenotypes detected in this investigation. 99.5%0 of Japanese tested is so-called Pi MM type in agreement with the previous reports which were based on acid starch gel electrophoresis (Harada and Omoto, 1970;Roberts et al, 1977). The three Pi M subtypes, inanely, M~M,, M1M~, M2M2, were detected in 70.1, 25,0, 4.9~, respectively of 1,264 samples, excluding those of rare variants.…”

Section: Resultssupporting

confidence: 90%

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

et al. 1979

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SummarySerum a~-antitrypsin phenotypes were determined by polyacrylamide gel slab isoelectric focusing in a sample from 1,271 unrelated healthy Japanese living in Tokyo. Three common Pi M subtypes (MIM~, M1M~ and M2M2) were found, and the allele frequencies estimated (Pim= 0.83, Pi~Z=0.17) were found to be similar to those observed in the European populations. A large Z ~ value, however, may indicate the presence of further microheterogeneity among Pi M subtypes. In contrast with Pi M subtypes, rare variants were found only in 0.55~ of the samples examined, and no Z gene was detected. A new fast variant of a~-antitrypsin named Pi Erokyo is reported.

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Section: Resultssupporting

confidence: 90%

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

et al. 1979

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“…Six surveys on Japanese population have been selected [49,75–79]. A total of 13 774 alleles has been studied.…”

Section: Resultsmentioning

confidence: 99%

“…Additional relevant studies were achieved by searching bibliographies of the articles retrieved through MEDLINE. A total of 85 surveys were retrieved [12–97]. Initial criteria for the selection of surveys were the following: 1) sample size >250 individuals (or >500 alleles); 2) AAT phenotype determination performed by means of crossed antigen–antibody electrophoresis (XAA), isoelectric focusing (IEF) in polyacrilamide gels, or polymerase chain reaction (PCR); and 3) PI type characterisation performed without any previous screening procedure.…”

Section: Methodsmentioning

confidence: 99%

“…Initial criteria for the selection of surveys were the following: 1) sample size >250 individuals (or >500 alleles); 2) AAT phenotype determination performed by means of crossed antigen–antibody electrophoresis (XAA), isoelectric focusing (IEF) in polyacrilamide gels, or polymerase chain reaction (PCR); and 3) PI type characterisation performed without any previous screening procedure. By applying these three main criteria, we have selected 59 out of the initial 85 studies [13–16,18,19,22–24,27–30,32–34,37–39,42,46,48,49,55,58–60,62–64,66,67,70,75–78,85,86,92,95,96]. Later, we have calculated S and Z 95% confidence intervals (CI) of outcomes for each of those 59 selected surveys for p at a significance level of α<0.05, using the 770 and 771 formulas of Documenta Geigy Scientific Tables [98] for a binomial distribution.…”

Section: Methodsmentioning

confidence: 99%

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Distribution of α1‐antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta‐analysis

Blanco¹,

Bustillo²,

Rodriguez³

2001

Clinical Genetics

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The objective of the present study was to review published surveys on allelic frequencies S and Z in countries outside Europe to evaluate the validity of the reported data. Studies on the topic, published from 1965 to May 2001, were retrieved using MEDLINE and bibliographic reference consultations. The criteria for the selection of the studies were the following: 1) sample size >or=250 individuals; 2) alpha1-antitrypsin phenotype determination performed by means of crossed antigen-antibody, isoelectric focusing in polyacrylamide gels, or polymerase chain reaction (PCR); 3) PI type determination performed without any previous screening procedure; 4) S and Z 95% CI of the reported outcomes within the limits of a calculated coefficient of variation. Forty-three out of 85 studies comply with the established criteria for being analysed. Worldwide maps of geographical distributions of PI S and PI Z frequencies have been designed by the authors by adding the data provided by these 43 selected studies to the 70 reported in a recent European meta-analysis.

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“…In this study, we did not examine serum α 1 -antitrypsin levels, because α 1 -antitrypsin deficiency is extremely rare in Japanese population [ 38 ]. In addition, smoking subjects with α 1 -antitrypsin deficiency develop COPD by middle age [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of a Decline in Aerobic Capacity with Development of Emphysema in Patients with Chronic Obstructive Pulmonary Disease: A Prospective Observational Study

et al. 2015

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In patients with COPD, CT assessment of emphysema and airway disease is known to be associated with lung function and 6-minute walk distance. However, it remains to be determined whether low attenuation area (LAA) on CT is associated with aerobic capacity assessed using cardiopulmonary exercise testing (CPET). In this prospective observational study, we repeatedly conducted high-resolution CT and CPET using a treadmill in 81 COPD patients over a median interval of 3.5 years. Two investigators independently scored LAA on images obtained at the aortic arch level, tracheal bifurcation level, and supradiaphragmatic level. Grades for the images of each lung were added to yield the total LAA score. Total LAA score was negatively correlated with peak aerobic capacity () (p<0.001, r = -0.485). LAA scores of the upper (aortic arch level) and the lower (supradiaphragmatic level) lungs were both significantly associated with peak . There was a significant correlation between total LAA score and peak CO2 output () (p<0.001, r = -0.433). Total LAA score was correlated with oxygen saturation at peak exercise (p<0.001, r = -0.634) and the estimated dead space fraction (p<0.001, r = 0.416). The mean annual change in total LAA score was significantly correlated with those in peak (p<0.001, r = -0.546) and peak (p<0.001, r = -0.488). The extent of emphysema measured by CT was associated with the results of CPET. The time-dependent changes in CPET data were also correlated with that in total LAA score. CT assessment could be a non-invasive tool to predict aerobic capacity in patients with COPD.

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Antitrypsin and Chronic Obstructive Pulmonary Disease among Japanese-American Men

Cited by 14 publications

References 15 publications

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution ofα 1 phenotypes in Japanese: Description of Pi M subtypes by isoelectric focusing

Distribution of α1‐antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta‐analysis

Correlation of a Decline in Aerobic Capacity with Development of Emphysema in Patients with Chronic Obstructive Pulmonary Disease: A Prospective Observational Study

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