Antitubercular agents. Part 1: Synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents

Kamal, Ähmed; Babu, Anish; Ramana, A. Venkata; Sinha, Rakesh Kumar; Yadav, J. S.; Arora, Sudarshan K.

doi:10.1016/j.bmcl.2005.01.085

Cited by 31 publications

(18 citation statements)

References 15 publications

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“…Phthalimide and its derivatives have also shown promising potential as anti‐tubercular agents . The amalgamation of phthalimide with phenazines has resulted in the identification of new molecular conjugates with better anti‐mycobacterial activity than isoniazid on drug resistant clinical isolates of M. tuberculosis …”

Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted Highly Efficient Route to 4‐Aminoquinoline‐Phthalimide Conjugates: Synthesis and Anti‐Tubercular Evaluation

et al. 2017

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Microwave assisted synthesis of 4-aminoquinoline-phthalimides was carried out in order to probe their anti-tubercular potential. Different conditions were screened both under conventional and microwave heating and the best results were obtained by microwave heating in DMSO at 160 o C for 2 min affording the desired 4-aminoquinoline-phthalimides in quantitative yields. Anti-tubercular evaluation against mc 2 6230 strain of Mycobacterium tuberculosis revealed 3 e, having an octyl chain length as spacer, to be the most potent of the synthesized compounds exhibiting MIC 99 of 13.7 mM.

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Section: Introductionmentioning

confidence: 99%

Microwave‐Assisted Highly Efficient Route to 4‐Aminoquinoline‐Phthalimide Conjugates: Synthesis and Anti‐Tubercular Evaluation

et al. 2017

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“…With the same motivation, a series of phthalimido-and naphthalimidolinked phenazines and found two compounds (151a and 151b) with a potency of MIC 1 μg/mL against M. tuberculosis H37Rv. These compounds also exhibited potency against resistant strains of Mtb (Kamal et al, 2005). Whereas in a series of phenazine carboxamides, compounds 152a and 152b showed excellent activity against Mtb H37Rv with a MIC of 0.19 μg/L and also against drug-resistant strains of Mtb.…”

Section: Benzothiadiazine and Pyranopyridine Derivativesmentioning

confidence: 97%

Anti-tubercular activity of some six membered heterocycle compounds

Asif¹

2019

Preprint

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The effectiveness in TB treatment is difficult because the structural composition of the mycobacterial cell wall is very complicated, which makes many drugs ineffective. Tuberculosis is still one of the most imperative infectious disease worldwide becouse its important reason is drug resistant, persistent or latent tuberculosis and synergism with HIV. Furthermore no any new chemical entity has come. The recently application of modern drug design promise to bring significant development in the fight against TB. In present review we discussed brief introduction of tuberculosis.

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“…With the same motivation, a series of phthalimido-and naphthalimido-linked phenazines were found two compounds (83a and 84b) with a potency of MIC 1 μg/mL against Mtb H37Rv. These compounds also exhibited potency against resistant strains of Mycobacterium [102]. Whereas in a series of phenazine carboxamides, compounds 85a and 85b showed excellent activity against Mtb H37Rv with a MIC of 0.19 μg/L and also against DR strains of Mtb.…”

Section: Quinoline and Quinoxaline Derivativesmentioning

confidence: 97%

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

Asif¹

2012

Med chem

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There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberclosis because mycobacterium species have developed resistant against currently used drugs, their toxic effect and long duration of therapy. The diazine (pyridazine, pyrimidine and piperazine) derivatives possess an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding for the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against MDR, XDR mycobacterium strains, and also in patient co-infected with HIV/AIDS.

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Antitubercular agents. Part 1: Synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents

Cited by 31 publications

References 15 publications

Microwave‐Assisted Highly Efficient Route to 4‐Aminoquinoline‐Phthalimide Conjugates: Synthesis and Anti‐Tubercular Evaluation

Microwave‐Assisted Highly Efficient Route to 4‐Aminoquinoline‐Phthalimide Conjugates: Synthesis and Anti‐Tubercular Evaluation

Anti-tubercular activity of some six membered heterocycle compounds

Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring

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