Antitubercular and Antiplasmodial Constituents of<i>Abrus precatorius</i>

Limmatvapirat, Chutima; Sirisopanaporn, Sinenart; Kittakoop, Prasat

doi:10.1055/s-2004-818924

Cited by 51 publications

(4 citation statements)

References 5 publications

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“…The use of Trema orientalis for treatment of viral infections has been reported elsewhere [24], while the anti-inflammatory activity of Cleome gynandra is supported by anti-inflammatory activity of a methanol extract of the leaves against adjuvant-induced arthritis in rats [25]. Other proven claims are the hepatoprotective effect of Cajanus cajan ethanol extract in rats [40] and the antimalarial activity of Abrus precatorius [39] and Clerodendrum myricoides [52,53]. Orthosiphon suffrutescens does not yet has proof of the concept laboratory results, but it is used in Rwanda for the treatment of malaria [45].…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District

Moshi

Otieno

Weisheit

2012

J Ethnobiology Ethnomedicine

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BackgroundThe Kagera region of north western Tanzania has a rich culture of traditional medicine use and practice. Traditional medicines are the mainstay of healthcare in this region and are known to support the management of many illnesses such as malaria, bacterial infections, epilepsy, gynecological problems and others. However, most of the plants being used have either not been documented or evaluated for safety and efficacy or both. This study, the sixth of an ongoing series, reports on the medicinal plants that are used at Kikuku village, Muleba District.MethodologyA semi-structured questionnaire was used to collect information on the common/local names of the plants, parts of the plants used, diseases treated, methods of preparing the herbal remedies, dosage of the remedies administered, frequency and duration of treatment and toxicity of the medicines. A literature review was carried out for information on the ethnomedical uses of the reported plants.ResultsA total of 49 plant species belonging to 47 genera and 24 plant families were documented. The family Euphorbiaceae and Asteraceae had the highest representation. The plants are used for the treatment of skin conditions (10 plants; 20%), bacterial infections and wounds (14 plants; 28.6%), malaria (14 plants; 28.6%), gastrointestinal disorders (11 plants; 22.4%), gynecological problems including infertility (8 plants; 16.3%), hypertension (5 plants; 10.2%), viral infections (7 plants; 14.3%), chest problems (5 plants; 10.2%), diabetes (3 plants; 6.1%), cancer (2 plants; 4.1%), inflammatory conditions (arthritis, rheumatism), HIV and AIDS, and hernia each treated by 1 plant (3 plants in total; 6.1%). Information obtained from the literature indicate that 25 (51.0%) of the therapeutic claims are supported by laboratory results or have similar claims of ethnomedical use from other countries.ConclusionHerbal remedies comprise an important and effective component of the healthcare system in Kikuku village with plants in the families Euphorbiaceae and Asteraceae comprising an important part of plants used in the indigenous healthcare management in the village. Malaria and bacterial infections dominate the list of diseases that are managed using traditional medicines.

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Section: Resultsmentioning

confidence: 99%

Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District

Moshi

Otieno

Weisheit

2012

J Ethnobiology Ethnomedicine

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“…The investigations of Muhammad and Amusa have reported the use of the stem bark of Abrus precatorius (Leguminosae-Caesalpinioideae) in the treatment of malaria [98]. Limmatvapirat et al isolated abruquinone B ( 86 ), which showed anti-plasmodial activity, with IC 50 = 1.5 μg mL −1 against the K1 strain of P. falciparum , from the stem bark of this plant [99]. Ajaiyeoba et al [100] also reported the use of the leaves and stem bark of Cassia siamea in the treatment of malaria.…”

Section: Fabaceae Ganodermataceae Lamiaceae and Loranthaceaementioning

confidence: 99%

A Bioactivity Versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa

Lifongo

Simoben

Ntie‐Kang

et al. 2014

Nat. Prod. Bioprospect.

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Traditional medicinal practices play a key role in health care systems in countries with developing economies. The aim of this survey was to validate the use of traditional medicine within local Nigerian communities. In this review, we examine the ethnobotanical uses of selected plant species from the Nigerian flora and attempt to correlate the activities of the isolated bioactive principles with known uses of the plant species in African traditional medicine. Thirty-three (33) plant species were identified and about 100 out of the 120 compounds identified with these plants matched with the ethnobotanical uses of the plants.

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“…An active component from the plant extract has been isolated and characterized as the isoflavanoid quinone, abruquinone which was shown (Limmatvapirat et al, 2004) to have an MIC of 12.5μg/mL against the M. tb. strain H 37 Rv.…”

Section: 0 Results and Discussionmentioning

confidence: 99%

Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

Ibekwe¹,

Nvau²,

Oladosu³

et al. 2014

Journal of Ethnopharmacology

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Ethnopharmacological significance Nigerian herbalists possess indigenous ethnomedicinal recipes for the management of tuberculosis and related ailments. Aim of the study To carry out a collaborative preliminary modern scientific evaluation of the efficacy of some Nigerian ethnomedicines used by traditional medicine practitioners (TMPs) in the management of tuberculosis and related ailments Materials and methods Ethnomedicinal recipes (ETMs) were collected from TMPs from locations in various ecological zones of Nigeria under a collaborative understanding. The aqueous methanolic extracts of the ETMs were screened against Mycobacterium bovis, BCG and Mycobacterium tuberculosis (M. tb.) strain H37Rv using the broth microdilution method. Results Extracts of ETMs screened against BCG showed 69% activity against the organism. The activities varied from weak, ≤ 2500μg /mL to highly active, 33μg /mL 64% of the extracts were active against M. tb. The activities of the extracts against M.tb. varied from weak, ≤ 2500μg /mL to highly active, 128μg/mL. There was 77% agreement in results obtained using BCG or M. tb. as test organisms Conclusion The results show clear evidence for the efficacy of the majority of indigenous Nigerian herbal recipes in the ethnomedicinal management of tuberculosis and related ailments. BCG may be effectively used, to a great extent, as the organism for screening for potential anti-M. tb. agents. A set of prioritization criteria for the selection of plants for initial further studies for the purpose of antituberculsis drug discovery research is proposed.

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Antitubercular and Antiplasmodial Constituents ofAbrus precatorius

Cited by 51 publications

References 5 publications

Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District

Ethnomedicine of the Kagera Region, north western Tanzania. Part 3: plants used in traditional medicine in Kikuku village, Muleba District

A Bioactivity Versus Ethnobotanical Survey of Medicinal Plants from Nigeria, West Africa

Some Nigerian anti-tuberculosis ethnomedicines: A preliminary efficacy assessment

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