Antituberculosis Drug-Associated DRESS: A Case Series

Allouchery, Marion; Logerot, Sophie; Cottin, Judith; Pralong, P.; Villier, Céline; Saïd, B. Ben

doi:10.1016/j.jaip.2017.11.021

Cited by 36 publications

(33 citation statements)

References 39 publications

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“…With regard to the most frequent antituberculosis drugs as a cause of DRESS, and the application of patch tests in the work-up, similar observations have been made in a recent review of 67 cases in France 27 : also in this series, rifampicin and isoniazid were the most frequently involved culprits, and skin tests, including patch tests, were rarely performed. Moreover, discrepancies did indeed exist between the results of epicutaneous tests and the outcome of reintroduction.…”

Section: Discussionsupporting

confidence: 76%

“…Moreover, discrepancies did indeed exist between the results of epicutaneous tests and the outcome of reintroduction. Nevertheless, these authors also argued for a drug allergy evaluation, including patch tests, to guide the reintroduction of drugs in order to rapidly optimize the treatment of patients …”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, these authors also argued for a drug allergy evaluation, including patch tests, to guide the reintroduction of drugs in order to rapidly optimize the treatment of patients. 27 In vitro tests, such as the lymphocyte transformation test (LTT), might also be valuable in the work-up of these patients. 22,28 According to some authors the LTT might be a more reliable, and also safer, alternative to patch tests.…”

Section: Discussionmentioning

confidence: 99%

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs: Two case reports and a review of the literature

et al. 2019

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Background: Patients suffering from drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculosis drugs often need to be retreated rapidly. Patch tests prior to the reintroduction of antituberculosis drugs are rarely performed.Objectives: To highlight those drugs most often involved in DRESS caused by antituberculosis drugs, illustrate the potential value of patch tests to identify these culprit(s), and provide insights into how to rapidly retreat these patients.Methods: A detailed description of the work-up of two illustrative patients, together with a literature review of similar cases, is provided.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs: Two case reports and a review of the literature

et al. 2019

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“…This entity is often diagnosed as erythematous maculopapular rash during the first days, being necessary close observation to avoid misdiagnosing . As all antituberculosis drugs pose a risk of DRESS, an early withdrawal of the culprit drugs is essential . Moreover, Epstein‐Barr virus and/or cytomegalovirus, and coagulation function evaluations are necessary in some DRESS to avoid disease complications …”

Section: Novel Tools For Managing Dhrmentioning

confidence: 99%

“…170 As all antituberculosis drugs pose a risk of DRESS, an early withdrawal of the culprit drugs is essential. 171 Moreover, Epstein-Barr virus and/or cytomegalovirus, and coagulation function evaluations are necessary in some DRESS to avoid disease complications. 172 In chemotherapy agents, essays to extend the infusion rates from one to two hours have been done to decrease the frequency of reactions with discrepant results.…”

Section: Novel Tool S For Manag Ing Dhrmentioning

confidence: 99%

Recent developments and highlights in drug hypersensitivity

Mayorga

Fernandez

Montañez

et al. 2019

Allergy

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Drug hypersensitivity reactions (DHRs) are nowadays the third cause of allergy after rhinitis and asthma with a significant increase in prevalence in both adults and paediatric population with new drugs included as culprit. For this, DHRs represent not only a health problem but also a significant financial burden for affected individuals and health systems. Mislabelling DHRs is showing to be a relevant problem for both, false label of drug allergic and false label of nonallergic. All this reinforces the need to improve accurate diagnostic approaches that allow an appropriate management.Moreover, there is a need for training both, nonallergist stakeholders and patients to improve the reaction identification and therefore decrease the mislabelling. The use of allergy cards has shown to be relevant to avoid the induction of DHRs due to the prescription of wrong medication.Recent developments over the last 2 years and highlights about risk factors, diagnostic approaches, mechanisms involved as well as prevention actions, and management have been reviewed. In these papers, it has been outlined the need for correct diagnosis and de-labelling of patients previously false-reported as allergic, which will improve the management and treatment of patients with DHRs. K E Y W O R D Sallergy diagnosis, allergy treatment, basic mechanisms, drug allergy, epidemiology | 2369

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