Antituberculous Activity of Substituted Thioureas

ANTIFUNGAL ACTIVITIES OF BISISOQUINOLINIUM AND BISQUINOLINIUM SALTS

“…1) most nearly resembles that for Mycobacterium phlei among bacteria previously examined (Collier et al, 1953). This provides another example of compounds possessing similar antifungal and antimycobacterial properties previously only observed in thioureas by Mayer, Eisman, and Konopka (1953).…”

Chemotherapy of Tuberculosis, Part IX: Synthesis and Screening of New Thiazolyl Thiocarbanilides

“…Keyphrases 0 Acetylcholinesterase reactivators-structure-activity relationships 0 Organophosphorus-inhibited cholinesterase reactivators 0 l-Pyridyl-2-phenylethanes, hydroxyimino methiodides-synthesis 0 UV spectrophotometry-identity, structure ~ It is well known that some quaternary pyridyloximes are used to reactivate the enzymatic activity of organophosphorus-inhibited acetylcholinesterase (1,2). The most active are those in which the hydroxyimino group is placed on side chains in the 2 or 4 position of the ring (1, 3).…”

“…Keyphrases 0 Tuberculosis chromotherapeutic agents 0 Thiazolyl thiocarbanilides-synthesis 0 Antitubercular activitythiazolyl thiocarbanilides Since the discovery of antimycobacterial activity of thioureas (1) numerous publications have appeared showing the pronounced activity of thiocarbanilides both in vitro as well as in experimental animals coupled with only a low rate of development of resistance (2)(3)(4)(5). Among the most potent compounds of this class are the thiocarbanilides bearing alkoxy groups in para positions (6-8).…”

Résultats à court terme d’un traitement de la lèpre par le 4,4’-diisoamyloxythiocarbanilide

“…Le pouvoir hautement tuberculostatique des N ,N '-diphényl-thiourées (ou thiocarbanilides) 4,4'-disubstituées a été signalé par M a y e r et ses collaborateurs (1), puis par deux d'entre nous (2). L 'utilisation de ces thiourées pour la chimiothérapie de la lèpre a été réalisée au Vietnam dès 1953 (3) et ensuite au Nigéria par D a v e y et ses collaborateurs (4), et, dans les deux cas, des résultats remarquables ont été enrégistrés avec ce type de produits, tant en ce qui concerne leur activité thérapeutique que leur innocuité.…”