Antituberculous Compounds. II. 2-Benzalhydrazinobenzothiazoles^1a

In Vitro Activities of Position 2 Substitution-Bearing 6-Nitro- and 6-Amino-Benzothiazoles and Their Corresponding Anthranilic Acid Derivatives againstLeishmania infantumandTrichomonas vaginalis

“…Since the 1990s, various pharmacological investigations of newly synthesized benzothiazole derivatives demonstrated interesting pharmacological activities and led to the development of new medications for treating human diseases. Among the most efficient compounds, riluzole, sulfathiazole, mercapto-2-benzothiazole, and 2-(phenylsulfonyl)-benzothiazole revealed neuroprotective (1,12), anticonvulsive (14), antiallergenic, and antimicrobial (7,11,19) activities, respectively, while other derivatives such as 2-(4-aminophenyl)-benzothiazoles exhibited potent antitumoral activity (3,5), probably due to their capacity to bind with tumor-specific proteins. In contrast to other anticancer drugs, such as acridines, that have been extensively studied for their antileishmanial (8) and trypanocidal activities (8), benzothiazoles have been poorly investigated.…”

Azidiniumsalze. 22. Mitteilung. über 3‐äthyl‐2‐tetrazo‐6‐X‐benzo[d]thiazoline und ihre Reaktivität: Ein Beitrag zur Chemie nucleophiler Carbene

“…Herstellung von 3-Athyl-2-uzido-6-niiro-benzo fd fthiazolium-tetru~uorbo~ul(4e). Eine Suspension von 2,14 g (10 mmol) 2-Chlor-6-nitrobenzo[&hiazol [27] …”

D-Luciferin, derivatives and analogues: synthesis and in vitro/in vivo luciferase-catalyzed bioluminescent activity

“…21 Nitrile 24a was synthesized from 2-chloro-6-aminobenzothiazole 23a, in turn obtained by nitration of 2-chlorobenzothiazole and reduction of the nitro derivative as previously described. 22 Acetylation of 23a gave the acetamide 23b from which the N-acetamide of 6-aminoluciferin (compound 20b) was obtained ( Figure 4). NH 3 and Na) and 24a (r.t., 2 h, 95% of 20a) or 24b (1 h, 88% of 20b).…”