Antituberculous Compounds. III. Benzothiazole and Benzoxazole Derivatives

1H and 13C chemical shifts for acridines: Part XVII. (1,3‐Benzothiazol‐2‐yl)amino‐9(10H)‐acridinone derivatives

“…10,11 The aromatic nucleophilic substitution of 2-chlorobenzothiazole and the corresponding aminoacridone was carried out in phenol at 80°C, to give 2, 6, 10 and 14. With 2-chloro-6-nitrobenzothiazole 12 we obtained the corresponding compounds 3, 7, 11 and 15 in the same way. Reductions of nitro to amino derivatives (4, 8, 12 and 16) were performed in DMF at 40 psi with Pd/C catalyst.…”

Synthesis, Biological Activity and Recent Advancement of Benzothiazoles: A Classical Review

“…Derivatives of 2-hydrazinobenzothiazole (Fig 28) have been synthesized for testing as antituberculous agents by Katz [39] is an ATP-phosphoribosyl transferase (ATPPRTase) that catalyzes the first step in the biosynthetic pathway for histidine. Among the enzymes in this pathway, only HisG represents a potential drug target for tuberculosis.…”

Untitled

“…67,68 . Katz et al synthesized some derivatives of 2-hydrazinobenzothiazole (2.34) and evaluated them for anti-tuberculous activity 77 . (c) Antihelmentic activity: Some fluoro benzothiazole Schiff bases (2.36) and sulfonamido pyrazole derivatives of fluorobenzothiazoles (2.37) were prepared and examined for anthelmintic activity against earthworm Perituma posthuma.…”