Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice

Li, Jian; Shi, Ming; Ma, Bao‐Qing; Niu, Ruixu; Zhang, Haizhao; Li, Kun

doi:10.1016/j.msec.2017.03.191

Cited by 29 publications

(26 citation statements)

References 26 publications

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“…The negative potential charge (−30 9 ± 3 1 mV) at natural pH also ensures the colloidal stability of the prepared Cur-NLs. In our previous study, we prepared quercetin-loaded nanoliposomes with the same method as this study and further found that quercetin-loaded nanoliposomes exhibit better tumor inhibition effect than free quercetin [23]. Nanomedicine is the use of nanotechnology to bring about improvements in healthcare.…”

mentioning

confidence: 88%

“…Cur-NLs were prepared according to an established method [23]. The lipid phase was prepared by dissolving SPC, CHOL, and curcumin (8 : 2 : 1) in dichloromethane-methanol mixture (2 : 1, V/V), then the mixture was removed by rotary evaporation at 60°C to form a thin film of lipids on the wall of the eggplant-shaped bottle.…”

Section: Preparation Of Cur-nls and Nanoliposomes (Nls)mentioning

confidence: 99%

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Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice

Niu

Liu

et al. 2019

Journal of Nanomaterials

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Curcumin is a natural phenolic compound extracted from the herb Curcuma longa L. rhizome and has received much attention on account of its biological properties. However, its poor solubility and low bioavailability limit its use. The purpose of this study was to synthesize curcumin-loaded nanoliposomes (Cur-NLs) to improve their bioavailability and evaluate the hepatoprotective effect of Cur-NLs against tetrachloromethane- (CCl4-) induced acute liver injury in mice. We prepared Cur-NLs by thin film dispersion method, and the characterizations of Cur-NLs were measured by transmission microscope, laser particle size analyzer, infrared spectrometer, and X-ray diffraction. After 14 days pretreatment of Cur-NLs, free curcumin, silybin, or PBS, the models of acute liver injury were established by CCl4 intraperitoneal injection in mice. The organ index, biochemical liver function parameters, histopathology, and antioxidant enzyme activities of liver tissues were measured further to evaluate the protective effects of Cur-NLs on liver injury. Compared with the CCl4 model control group, pretreatment of Cur-NLs effectively reduced the serum levels of ALT, AST, and ALP and attenuated the hepatic necrosis induced by CCl4 intoxication. Furthermore, Cur-NL pretreatment remarkably exhibited decreased MDA level and increased SOD, GPx, and CAT activities compared to CCl4 model control group. Compared with the free curcumin group, the Cur-NLs also showed a better hepatoprotective effect. These observations imply that Cur-NLs act as a promising hepatoprotective agent in reducing liver oxidative stress produced by different stress factors.

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confidence: 88%

Section: Preparation Of Cur-nls and Nanoliposomes (Nls)mentioning

confidence: 99%

Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice

Niu

Liu

et al. 2019

Journal of Nanomaterials

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“…16 Gold nanoparticles-conjugated quercetin suppressed migratory and invasive potential of MCF-7 and MDA-MB-231 cells. 19,20 Markedly reduced levels of VEGF-C and phosphorylated-VEGFR3 were found in OCT4 silenced Eca109 cells. 17 Although it seems clear that quercetin effectively downregulated VEGF and VEGFR in different types of cancers but we still have insufficient information about the effect of quercetin on the transcriptional factors, which positively and negatively regulated expression of VEGF and VEGFR in different types of cancers.…”

Section: Vegf/vegfr Signaling Pathwaymentioning

confidence: 99%

“…Tumors from quercetin-treated xenografted mice showed markedly reduced levels of AKT, mTOR, and P70S6K proteins. 19,20 Biologically active (poly(phenylalanine)-b-poly(L-histidine)-b-poly(ethylene glycol) polypeptide nanoconstructs were used for the delivery of payload consisting of doxorubicin and quercetin. Poly D-L-lactide-coglycolide decorated with chitosan and polyethylene glycol effectively delivered quercetin.…”

Section: Preclinical Studiesmentioning

confidence: 99%

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Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Farooqı

Jabeen

Attar

et al. 2018

J of Cellular Biochemistry

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Recent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high-throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β-catenin pathway, Janus kinase-signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.

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Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

Wang

Yang

et al. 2021

Phytotherapy Research

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Decrepitude and apoptosis of bone mesenchymal stem cells (BMSCs) induced by reactive oxygen species (ROS) lead to inhibited osteogenic differentiation, causing decreased bone density and osteoporosis. Quercetin, a bioactive component of Solanum muricatum extracts, promotes the osteogenic differentiation of BMSCs and ameliorates the symptoms of osteoporosis in vivo. However, the detailed mechanism underlying this process remains unclear. The study aims to reveal the regulatory mechanism of quercetin in BMSCs. Mouse BMSCs (mBMSCs) were isolated from the bone marrow and characterized by flow cytometry. QRT-PCR and western blot assays were performed to evaluate the expression levels of related genes and proteins. Alkaline phosphatase (ALP) staining and Oil Red O staining of lipids were used to estimate the osteogenesis and adipogenesis levels of mBMSCs, respectively. Quercetin treatment (2 and 5 μM) induced significant upregulation of antioxidant enzymes, SOD1 and SOD2, in mBMSCs. Quercetin promoted osteogenic differentiation and inhibited adipogenic differentiation of mBMSCs. Quercetin treatment enhanced the phosphorylation of AMPK protein and upregulated the expression of SIRT1, thus activating the AMPK/SIRT1 signaling pathway in mBMSCs. Quercetin promoted osteogenic differentiation and antioxidant responses of mBMSCs by activating the AMPK/SIRT1 signaling pathway.

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Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice

Cited by 29 publications

References 26 publications

Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice

Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

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Antitumor activity and safety evaluation of nanaparticle-based delivery of quercetin through intravenous administration in mice

Cited by 29 publications

References 26 publications

Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice

Nanoencapsulation of Curcumin and Its Protective Effects against CCl4-Induced Hepatotoxicity in Mice

Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer

Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

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Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice

Nanoencapsulation of Curcumin and Its Protective Effects against CCl₄-Induced Hepatotoxicity in Mice