Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

Santos, Paula Christina Mattos dos; Feuser, Paulo Emílio; Cordeiro, Arthur Poester; Scussel, Rahisa; Abel, Jéssica da Silva; Machado-de-Ávila, Ricardo Andrez; Rocha, Maria Eliane Merlin; Sayer, Cláudia; Araújo, Pedro Henrique Hermes de

doi:10.1080/09205063.2020.1782699

Journal of Biomaterials Science, Polymer Edition

2020

DOI: 10.1080/09205063.2020.1782699

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Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

Paula Christina Mattos dos Santos

Paulo Emílio Feuser

Arthur Poester Cordeiro

et al.

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Cited by 7 publications

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“…[14][15][16] Thiol-ene polymerization, a click-chemistry reaction in miniemulsion, has proven to be an excellent alternative to synthesize polymeric nanoparticles using renewable resources with potential for use as drug carriers. [17][18][19][20] Many in vitro studies have demonstrated the biocompatibility 17,18,20 /hemocompatibility 18,21 and biodegradability 22,23 of this polymeric nanoparticles obtained by thiol-ene chemistry, as well as, their use as target drug delivery systems due to its potential for surface modification. 19,24 In a recent study on MNPs encapsulation via thiol-ene polymerization in miniemulsion, the authors reported the successful synthesis of superparamagnetic PTEe nanoparticles via thiol-ene miniemulsion polymerization using two different thiols (dithiol and tetrathiol) and evaluated their in vitro cytotoxicity in human breast cancer (MDA-MB 231) cells by hyperthermia.…”

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Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

et al. 2021

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Poly(thioether-ester) (PTEe) nanoparticles obtained by thiol-ene polymerization have received attention of many researchers due to several advantages, including, biocompatibility and biodegradability. The search for new nanomaterials requires toxicity studies to assess potential toxic effects of their administration. Therefore, the aim of this study was to evaluate the in vivo acute toxicity of PTEe and poly(thioetherester)-coated magnetic nanoparticles prepared by thiol-ene polymerization in miniemulsion. These nanoparticles presented a mean size of approximately 120 nm, spherical morphology, and negative surface charge. Doses of 40 mg/kg were administered intraperitoneally to Swiss mice and nociceptive, behavioral and biochemical parameters were investigated in five different organs. None of the nanoparticles led to any alterations in the nociceptive and behavioral responses. Biochemical alterations were observed in liver, decreasing the sulfhydryl and glutathione (GSH) levels, suggesting the dependence of the GSH metabolism in the elimination of the nanoparticles. In general, both nanoparticle types did not cause disturbances in biochemical parameters analyzed in others organs. These results suggest that both nanoparticle types did not induce acute toxicity to the different organs evaluated, reinforcing the biocompatibility of PTEe nanoparticles synthetized by thiol-ene polymerization.

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Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

et al. 2021

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Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

Aslam

Shukrullah

Naz

et al. 2021

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encountering non-target tissues, cells, or areas. [2] An overview of the general drug delivery system is given in Figure 1. Over four decades ago, the idea of "magnetized medication delivery" was proposed as a highly potential use of magnetic nanoparticles. Magnetic nanostructures are granules comprising of polymeric materials and medicine together with ferromagnetic components (magnetite). Substances utilized in the creation of nanostructures are sterilizable, harmless, and disposable; good examples include gelatin, ethyl cellulose, albumin, and collagen. [3] The idea of magnetostrictive aiming begins with linking active ingredients to magnetic nanocrystals accompanied by the infusion and assistance of these molecules to a target tissue under the impact of regionalized strong magnetic field and keeping there at site till the completion of the treatment and ultimate disposal. Literature shows six kinds of magnetic substances, i.e., antiferromagnetic, ferromagnetic, superparamagnetic, ferromagnetic, paramagnetic and diamagnetic. [4] The detail of these substances is given in Table 1. Once the external field is withdrawn, paramagnetic components shed magnetic momentum and super-paramagnetic substances turn nonmagnetic, unless an additional field is applied. [5] Nanomaterials may transport huge dosages of medicines to obtain great localized accumulation, preventing cytotoxic and other undesirable side symptoms occurring due to excessive dosing frequency in other regions of the body. In situ investigations showed that real clinical studies are a difficult job due to length management, durability, cytocompatibility, and adhesive coating for drug action as well as other physiologic characteristics. [3,6,7] The details of possible uses of magnetic nanoparticles (MNPs) in biomedical applications are given in Figure 2.The aim of creating or even strengthening administration methods is to deliver medicines to specific areas of the patient's system via a channel that can regulate the therapeutic distribution in terms of a physiologic or biochemical stimulus. Synthetic polymer-based microcapsules, microemulsions, and micelles are reported to be efficient in improving drug selectivity, reducing therapeutic toxicity, enhancing clinical oral bioavailability, and safety of medical products against biological degeneration. [15,16] Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applie...

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4-Nitrochalcone as a potential drug in non-clinical breast cancer studies

Galindo,

Milani,

de Lima

et al. 2024

Chemico-Biological Interactions

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Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

Cited by 7 publications

References 63 publications

Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

Evaluation of the in vivo acute toxicity of poly(thioether‐ester) and superparamagnetic poly(thioether‐ester) nanoparticles obtained by thiol‐ene miniemulsion polymerization

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

4-Nitrochalcone as a potential drug in non-clinical breast cancer studies

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