Antitumor activity of 1,2-diaminocyclohexaneplatinum complexes against Sarcoma-180 ascites form

Kidani, Yoshinori; Inagaki, Kenji; Iigo, Masaaki; Hoshi, Akio; Kuretani, Kazuo

doi:10.1021/jm00210a029

Cited by 218 publications

(105 citation statements)

References 2 publications

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“…Kidani and co-workers have reported that platinum complexes with l,2-diaminocyclohexane, having different configurations at the two chiral carbons bridging the two nitrogens, had biological activities dependent on the chirality of the diamine ligand (30)(31)(32)(33). Although the isomers with R,R and S,S configurations at the asymmetric carbons produce the same type of intra-and interstrand cross-links (34), the biological activity of the two enantiomers is different, and the R,R enantiomer exhibits higher antitumor activity and lower mutagenicity than the S,S isomer (35).…”

Section: Chiral Discrimination In Platinum Anticancer Drugsmentioning

confidence: 99%

Chiral discrimination in platinum anticancer drugs.

Benedetti

Malina

Kašpárková

et al. 2002

Environ Health Perspect

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In this article we review the biological activity of analogs of the antitumor drug cisplatin that contain chiral amine ligands. Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes. Because double-helical DNA has a chiral structure, interaction with enantiomeric complexes of platinum should lead to diastereomeric adducts. It has been demonstrated that DNA cross-links of platinum complexes with enantiomeric amine ligands not only can exhibit different conformational features but also can be processed differently by the cellular machinery as a consequence of these conformational differences. These results expand the general knowledge of how the stereochemistry of the platinum-DNA adduct can influence the cell response and contribute to understanding the processes that are crucial for antitumor activity. The steric requirements of the chiral ligands, in terms of configuration and flexibility, are also elucidated.

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Section: Chiral Discrimination In Platinum Anticancer Drugsmentioning

confidence: 99%

Chiral discrimination in platinum anticancer drugs.

Benedetti

Malina

Kašpárková

et al. 2002

Environ Health Perspect

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“…It must also be mentioned that oxaliplatin, a platinum‐based antineoplastic agent used for colorectal cancer was discovered by Kidani et al 55. in 1976.…”

Section: Colorectal Surgerymentioning

confidence: 99%

Gastroenterological surgery in Japan: The past, the present and the future

Colvin

Mizushima

Eguchi

et al. 2017

Annals of Gastroent Surgery

138

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In the last two centuries, there has been remarkable progress in the field of gastroenterological surgery, including the curative resection of cancers, replacement of failed organs through transplantation, increased safety of undergoing major surgeries and decreased operative morbidity through developments in minimal access surgery. Japan has very much been at the forefront of these advances, as is evident from the present review, from advancing the surgical management of gastric cancer to the pioneering work in live‐donor transplantation. This review also highlights many instances where surgical management of the same pathologies has evolved differently between Japan and the West. It is encouraging that many procedures established in Japan are eventually taken up by the West, often after rigorous assessment affirming the quality and applicability of such techniques. In Japan, many of the crucial issues in gastroenterological surgery are increasingly addressed through large multi‐institutional prospective control trials, ensuring that Japanese surgeons continue to contribute to the advances in gastroenterological surgery.

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“…DACHPt has shown a wide and markedly different spectrum of activities than CDDP, such as lower toxicity than CDDP and no cross-resistance to it in many CDDP-resistant cancers (Rixe et al 1996;Zhang & Lippard 2003). However, DACHPt is significantly less soluble in water than CDDP (Kidani et al 1978). To enhance the water solubility of DACHPt as well as pinpoint delivery, DACHPt-loaded micelles were developed by metal complexation between platinum and carboxylic acids contained in a PEG-PGlu block copolymer (figure 4; Cabral et al 2005).…”

Section: Polymeric Micelles Delivering Anti-cancer Drugsmentioning

confidence: 99%

Polymeric micelles from poly(ethylene glycol)–poly(amino acid) block copolymer for drug and gene delivery

Osada

Christie

Kataoka

2009

J. R. Soc. Interface.

186

125

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Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.

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Antitumor activity of 1,2-diaminocyclohexaneplatinum complexes against Sarcoma-180 ascites form

Cited by 218 publications

References 2 publications

Chiral discrimination in platinum anticancer drugs.

Chiral discrimination in platinum anticancer drugs.

Gastroenterological surgery in Japan: The past, the present and the future

Polymeric micelles from poly(ethylene glycol)–poly(amino acid) block copolymer for drug and gene delivery

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