2018
DOI: 10.20902/ijptr.2018.11209
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Antitumor Activity of Beta Glucan Extract from Oyster Mushroom (Pleurotus ostreatus Jacq. P. Kum) on DMBA-Induced Breast Cancer in vivo

Abstract: It has been indicated that beta glucan is potential for anticancer due to its activity as immunomodulator. The aim of this research was to study the antitumor activity of oyster mushroom's beta glucan in female rats induced with 7,12 Dimethylbenz(a)anthracene (DMBA) as cancer promotor. Experimental rats were divided into four groups which consist of control group, DMBA group and beta glucan-treated groups (with two different doses of 0.25 g.kg-1 and 1 g.kg-1). Inhibition of carcinogenesis were demonstrated in … Show more

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Cited by 4 publications
(2 citation statements)
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“…Vitamin B6 has a vital role to prevent cardiovascular disease [119], kidney stones, and immune and cognitive functions [120]. It is also used for the treatment DOI: http://dx.doi.org/10.5772/intechopen.104091 of premenstrual syndrome [121]. Vitamin B6 can protect from side effects of oral contraceptives, nausea, and vomiting in pregnancy [122] and reduce depression.…”
Section: Functionmentioning
confidence: 99%
See 1 more Smart Citation
“…Vitamin B6 has a vital role to prevent cardiovascular disease [119], kidney stones, and immune and cognitive functions [120]. It is also used for the treatment DOI: http://dx.doi.org/10.5772/intechopen.104091 of premenstrual syndrome [121]. Vitamin B6 can protect from side effects of oral contraceptives, nausea, and vomiting in pregnancy [122] and reduce depression.…”
Section: Functionmentioning
confidence: 99%
“…Polysaccharides also increased the production of caspase-3, Bax, caspase-9, and phospho-JNK, as well as reducing mitochondrial membrane potential, resulting in cell death [120]. Supplementing rats with glucan produced from oyster mushrooms with breast cancer was associated with a decrease in tumor recurrence, tumor volume, and total tumor nodules [121].…”
Section: Effect Of Mushroom On Cancermentioning
confidence: 99%