Antitumor activity of Cuphea ignea extract against benzo(a)pyrene-induced lung tumorigenesis in Swiss Albino mice

Abstract

HighlightsPhenolic compounds from Cuphea ignea extract were identified.Chemopreventive and chemotherapeutic potentials of C. ignea extract were demonstrated in mice.Tumor, inflammatory, oxidative stress, apoptotic and angiogenic markers were investigated.Histopathological analysis showed improved lung tissues after treatment with C. ignea extract.

<p>Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice</p>

“…34 The significant drop in the relative lung weight and increased body weight by DAS were consistent with previous chemopreventive studies of various plant extracts and their active components in chemically induced lung cancer. [35][36][37] The histopathological data studies confirmed the tumor growth inhibitory and the protective effect of DAS in the lungs ( Figure 5A). The data also revealed that the pretreatment of DAS controlled the invasion of cancer cells in the liver leading to apoptosis ( Figure 5B).…”

“…The results also agreed with the studies that reported the considerable decrease in the chemical carcinogen-induced activities of these tumor marker enzymes by different plant extracts or its active constituents. 36,47,48 A B Figure 9 Effect of DAS on the expression of FASN by IHC in lung and liver tissues. Notes: The representative images of IHC analysis of FASN expression in the: (A) lungs, (B) Liver.…”

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies

“…Cuphea ignea A. DC. Which is known as firecracker or cigar flower, is often grown as an ornamental plant in the tropics and as a summer bedding in the temperate zone [ 13 ]. Cuphea ignea A. DC.…”

“…Recent reports revealed that Cuphea ignea A. DC. possesses significant antiulcerogenic, antitumor, antioxidant and antihypertensive activities [ [13] , [14] , [15] ]. Thirteen compounds were identified in Cuphea ignea A. DC.…”

“…Thirteen compounds were identified in Cuphea ignea A. DC. ethanolic extract including flavonoids, phenolic acids, hydrolysable tannin and coumarin compound [ 13 ]. Different extracts of the plant possess high content of polyphenols comprising phenolic acids and flavonoids especially the ethanolic extract of the leaves [ 14 ].…”