Antitumor activity of new hydridotris(pyrazolyl)borate ruthenium(ii) complexes containing the phosphanes PTA and 1-CH3–PTA

Synthesis and Structural Features of New Ruthenium(II) Complexes Containing the Scorpionate Ligands Tris(pyrazol‐1‐yl)methanesulfonate (Tpms) and Tris(pyrazol‐1‐yl)methane (Tpm)

“…The N-Ru-N angles and Ru-N bond lengths for both complexes are in the range found for hydridotris(pyrazolyl)borate ruthenium(II) complexes, [9] and the small N-Ru-N angles (80.01-86.04°) reflect the fac environment of the ligand around the ruthenium ion. The P-Ru-P angle in 3 [97.18(3)°] is significantly larger than that in 2 [93.337(16)°] as a consequence of the steric bulk of the PPh 3 ligand.…”

“…[9] In this article, we report the synthesis and structural features of ruthenium(II) complexes bearing the scorpionate ligand Tpms (Figure 1). Furthermore, our interest in water soluble complexes, which could be used in biological assays, prompted us to study phosphane substitution with the water soluble 1,3,5-triaza-7-phosphatricyclo[3.3.1.1 3,7 ]decane (PTA) phosphane as well as electrophilic attacks on coordinated PTA phosphanes yielding new ruthenium(II) complexes.…”

Antimicrobial and Antitumor Activity of Enantiopure Pybox–Osmium Complexes

“…Binding to DNA is usually associated with chloride dissociation; however, the fact that the complexes do not dissociate chloride ions in the absence of guanine or cytosine bases (see above) does not disagree with the DNA binding, as we recently reported ruthenium complexes [RuCl{κ 3 ( N , N , N )‐Tp}(PR 3 )(PTA)] that do not dissociate chloride ions under physiological conditions but they do interact with nucleobases. Thus, in the presence of the 14‐mer single‐stranded oligonucleotide 5′‐ATACATGGTACATA‐3′, new species resulting from the interaction of different ruthenium fragments with the oligonucleotide were obtained as shown by MALDI‐TOF mass spectrometry 3a…”

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo—A Comparison of O,O‐, S,O‐, and N,N‐Chelate Effects

“…García‐Fernández et al. successfully synthesized bioactive hydrotris(pyrazol‐1 H‐ yl)borate ruthenium(II) complexes containing PTA (1,3,5‐triaza‐7‐phosphaadamantane) and 1‐CH 3 ‐PTA (1‐methyl‐3,5‐diaza‐1‐azonia‐7‐phosphaadamantane) and postulated that the increase in size of the Tp ligand in comparison with the cyclopentadienyl (Cp) ligand might favor the cytotoxic activity . Gandin et al.…”

“…While the use of tris(pyrazolyl)borate ligands in the synthesis of antitumor agents is quite rare, each study has implicated the scorpionates as ad etermining factor in the activity of the complexes.G arcía-Fernµndez et al successfully synthesized bioactive hydrotris(pyrazol-1H-yl)borate ruthenium(II) complexes containing PTA( 1,3,5-triaza-7-phosphaadamantane) and1 -CH 3 -PTA( 1-methyl-3,5-diaza-1-azonia-7phosphaadamantane) and postulated thatt he increase in size of the Tp ligand in comparison with the cyclopentadienyl (Cp) ligand might favor the cytotoxic activity. [19] Gandine tal. also reportedt he anticancer activity of copper(I) complexes bearing unsubstituted tris(pyrazol-1H-yl)borates as well as four derivatives, containing electron donating and withdrawing groups, in vivo and in vitro.…”