Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor

Toshkova, Reneta; Manolova, Nevena; Gardeva, Elena; Ignatova, Miléna; Yossifova, L.; Rashkov, Iliya; Alexandrov, M.

doi:10.1016/j.ijpharm.2010.08.039

Cited by 79 publications

(35 citation statements)

References 30 publications

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“…Various polymers have been electrospun, ranging from natural polymers like collagen, gelatin, chitosan, silk fibroin, and hyaluronic acid to synthetic polymers such as poly(lactic acid) (PLA), poly(ε-caprolactone) (PCL), polyethylene oxide, and copolymers, such as poly (l-lactide-co-caprolactone) and poly(lactic-co-glycolic acid) (PLGA), to fabricate scaffolds with desired properties for specific tissue regeneration and drug-delivery applications. 6 Drug-loaded nanofibrous membrane can be applied topically for skin and wound healing 7 or as a postoperation implant for antibiotic, antifungal, antimicrobial, 8 and anticancer 9 drug delivery. Electrospinning provides the opportunity for direct encapsulation of drugs into the electrospun fibers.…”

Section: Electrospinning and Electrospraying For Drug Delivery Electrmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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Section: Electrospinning and Electrospraying For Drug Delivery Electrmentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

204

104

View full text Add to dashboard Cite

show abstract

“…Both, chitosan and its quaternized derivative, have been extensively studied for wound healing (Niekraszewicz 2005;Ong et al 2008), drug (Meng and Sturgis 2011;Park et al 2010;Pérez Quiñones et al 2011;Rajan and Raj 2013) and gene delivery (Dehousse et al 2010b;Mao et al 2010;Tang et al 2014), tissue engineering (Abdel-Fattah et al 2007;Croisier and Jérôme 2013;Kim et al 2008), in the form of gels (Anaya et al 2013;Das Neves and Bahia 2006), membranes (Silva et al 2013a, b), sponges (De Castro et al 2012;Noel et al 2010;Wang et al 2006), scaffolds (Huang et al 2005;Sajesh et al 2013;Vande Vord et al 2002;Zakhem et al 2012), micro-and nanoparticles (Agnihotri et al 2004;Dev et al 2010;Harris et al 2011;Songsurang et al 2011), fibres (Albanna et al 2013;Ma et al 2013;Zhou et al 2013) and nanofibres (Chen et al 2014;Fouda et al 2013;Tchemtchoua et al 2011;Toshkova et al 2010), as well as antimicrobial coatings for textiles (Wazed et al 2011;Zemljic et al 2009;Zemljič et al 2013). It has to be pointed out that present trend in chitosan use for fibre applications is in the nanoparticles preparation.…”

Section: Introductionmentioning

confidence: 99%

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

2015

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Adsorption of chitosan solution as well as chitosan nanoparticles dispersion onto cellulose fibres was implemented at pH = 4 and 7, respectively, in order to investigate the influence of different pH values on chitosan macromolecules' conformation and consequently on its adsorption ability and resultant coating morphology, as well as on antimicrobial activity of coated fibres. Adsorption capacity, charging behaviour and electrokinetical response of fibres at different pH values were analysed by determining zeta potential. Obtained results were related to the antimicrobial activity of fibres, determined by standard ASTM E2149 method.

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“…In addition, electrospinning affords great flexibility in producing polymer fibers with customizable fiber size, porosity, drug loading rate and release mechanisms, leading to a possibility of tailoring the drug release rate for each application. Another advantage of drug-loaded electrospun fibers is their potential as implantable device intratumorally, adjacent to tumor, or at the surgical resection margins for cancer chemotherapy of solid tumors (Xu et al, 2009;Toshkova et al, 2010;Luo et al, 2012;Ignatova et al, 2013;Liu et al, 2013;Zamani et al, 2013, Zheng et al, 2013a.…”

Section: Introductionmentioning

confidence: 99%

Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer

et al. 2014

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The purpose of this study was to evaluate both in vitro and in vivo anticancer activities against colorectal cancer (CRC) of electrospun polylactide (PLA) nanofibers loaded with 5-fluorouracil (5-Flu) and oxaliplatin. For in vitro evaluation, human CRC HCT8 cells were directly exposed to the drug-loaded fiber mats, followed with MTT and flow cytometry (FCM) assay. For in vivo evaluation, the drug-loaded fiber mats were locally implanted into mouse colorectal CT26 tumor-bearing mice, followed with histological analysis and detection of survival rate. The results showed that the drug-loaded fiber mats was similar to that of the combination of free 5-Flu and oxaliplatin in vitro cytotoxicity but was much superior to intravenous injection of free drug in vivo anticancer activities, presenting with suppressed tumor growth rate and prolonged survival time of mice. In conclusion, anticancer activities of 5-Flu and oxaliplatin against CRC can be significantly improved by using PLA electrospun nanofibers as local drug delivery system.

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Antitumor activity of quaternized chitosan-based electrospun implants against Graffi myeloid tumor

Cited by 79 publications

References 30 publications

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

Antitumor activity of electrospun polylactide nanofibers loaded with 5-fluorouracil and oxaliplatin against colorectal cancer

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