Antitumor activity of the immunomodulatory lead Cumaside

Aminin, Dmitry L.; Chaykina, E.L.; Агафонова, И. Г.; Avilov, Sergey A.; Kalinin, Vladimir I.; Stonik, Valentin A.

doi:10.1016/j.intimp.2010.03.003

Cited by 55 publications

(57 citation statements)

References 17 publications

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“…Triterpene glycosides from sea cucumbers demonstrate that wide spectrum of biological effects, such as antifungal, antitumor, hemolytic, cytostatic, pro-apoptotic and immunomodulatory activities. Frondoside A and Cucumariosides showed cancer preventive effects on both in vitro and in vivo models [58][59][60]. The dolastatins were originally reported from the Indian Ocean sea hare, Dolabella auricularia.…”

Section: Miscellaneousmentioning

confidence: 99%

Introduction to Anticancer Drugs from Marine Origin

Kim

Kalimuthu

2014

Handbook of Anticancer Drugs From Marine Origin

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The chemical and biological diversity of the marine environment is extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodological advances in elucidation of structure, synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents from marine pipeline. To understanding the marine derived anticancer compounds are useful in pharmaceutical industry and clinical applications. The marine sponges, algae, microbes, tunicates and other species from the marine pipeline are the important sources for biological active compounds. The past decade has seen a dramatic increase in the number of preclinical anticancer lead compounds from diverse marine life enter human clinical trials.Keywords Anticancer · Algae · Sponges · Marine · Bioactive compounds IntroductionCancer is a dreadful human disease, increasing with changing life style, nutrition, and global warming. A report released by the World Health Organization (WHO) showed that an estimated 12.7 million people were diagnosed with cancer globally and about 7.6 million people died of it in 2008. As estimated in this report, more than 21 million new cancer cases and 13 million deaths are expected by 2030. Although cancer accounts for around 13 % of all deaths in the world, more than 30 % of cancer deaths can be prevented by modifying or avoiding key risk factors [1]. However, almost all of the chemotherapy drugs currently in the market cause serious side effects. Natural products and their derivatives represent more than 50 % of all the drugs in clinical use of the world. Higher plants contribute not less than 25 % of the total. Almost 60 % of drugs approved for cancer treatment are of natural origin.S.-K. Kim and S. Kalimuthu 2 Although marine compounds are underrepresented in current pharmacopoeia, it is anticipated that the marine environment will become an invaluable source of novel compounds in the future [2].Marine nutraceuticals can be derived from a vast array of sources, including marine plants, microorganisms, and sponges. Marine nutraceutical products currently promoted to various countries include fish oil, chitin, chitosan, marine enzymes and chondroitin from shark cartilage, sea cucumbers and mussels. Polysaccharides derived from alga, including alginate, carrageenan and agar are widely used as thickeners and stabilizers in a variety of food ingredients. In addition, Omega PUFA (Polyunsaturated fatty acid) is an important ingredient to the nutraceutical industry [3]. It has been proven that Omega-PUFA, especially eicosapentaenoic acid (EPA) and docosahexenoic acid (DHA) play a significant role in number of aspects of human health [4].More than 70 % of our planet's surface is covered by oceans. An exciting "marine pipeline" of new anticancer clinical and preclinical agents has emerged from intense efforts over the past decade to more effectively explore the rich chemical diversity offered by marine life. The chemical adaptations generally take the form of ...

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Section: Miscellaneousmentioning

confidence: 99%

Introduction to Anticancer Drugs from Marine Origin

Kim

Kalimuthu

2014

Handbook of Anticancer Drugs From Marine Origin

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“…The animals were treated with cucumarioside A 2 -2 complexed with cholesterol to decrease the hemolytic and cytotoxic effects of the glycoside [12]. The cucumarioside A 2 -2 complexed with cholesterol was dissolved in sterile saline in an ultrasound bath for 10 min and injected intraperitoneally (i.p.)…”

Section: Methodsmentioning

confidence: 99%

“…Injections of solutions of some sea cucumber triterpene glycosides may induce tumor growth regression in animals [8,11]. Recently, it was found that the new immunomodulatory lead Cumaside, based on the holothurian triterpene glycoside cucumarioside A 2 -2, possesses the ability at low dosages to inhibit the development of tumors, demonstrates significant antitumor activity in vivo, and exhibits synergism in combined action with 5-fluorouracil [12]. However, the molecular mechanism(s) of the antitumor action of cucumarioside A 2 -2 and other glycosides on cancer cells remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Antitumor Activity of Cucumarioside A<sub>2</sub>-2

et al. 2013

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Background: The cytotoxic activity of sea cucumber glycosides against different types of cells and cell lines, including human tumor cell lines, has been studied for many years. However, the molecular mechanism(s) of the antitumor action of triterpene glycosides on cancer cells remain unclear. This article reports a continuation of investigations of triterpene glycoside cucumarioside A₂-2 isolated from the Far-Eastern sea cucumber Cucumaria japonica. It describes a study of glycoside anticancer activity in vivo and glycoside interaction with mouse Ehrlich carcinoma cells in vitro. Methods: The cytotoxicity of cucumarioside A₂-2 and its effect on apoptosis, the cell cycle, DNA biosynthesis and p53 activity, and glycoside anticancer action against Ehrlich carcinoma cells were studied. Results: Cucumarioside A₂-2 influences tumor cell viability at micromolar concentrations. The EC₅₀ for glycoside estimated by nonspecific esterase assay and MTT assay was 2.1 and 2.7 μM, respectively. Cucumarioside A₂-2 at a subcytotoxic range of concentrations exhibits a cytostatic effect by blocking cell proliferation and DNA biosynthesis in the S phase. It may induce apoptosis in tumor cells in a caspase-dependent way, bypassing the activation of the p53-dependent segment. Conclusion: The anticancer and proapoptotic properties of cucumarioside A₂-2 may be due to direct interaction of the glycoside with tumor cells. The in vivo anticancer effect of cucumarioside A₂-2 may be associated with the ability of the drug to arrest the cell cycle in the synthetic phase and induce programmed tumor cell death.

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“…Sea cucumbers contain high protein levels, low sugar and fat content, and no cholesterol [5]. They are also rich in bioactive compounds which exhibit numerous medicinal benefits and health functions, especially the triterpene glycosides (saponins) [6][7][8], chondroitin sulphates [9,10], glycosaminoglycan [11,12], sulphated polysaccharides [13][14][15][16], sterols (glycosides and sulphates) [17], phenolics [18], peptides [19], cereberosides [20], and lectins [21][22][23] (Figure 1). Therefore, sea cucumbers have been well recognized as a tonic and traditional remedy in East and South East Asia literature for various diseases.…”

Section: Introductionmentioning

confidence: 99%

Cosmeceuticals Properties of Sea Cucumbers: Prospects and Trends

et al. 2017

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Cosmeceutical, a new term in the cosmetic industry, refers to cosmetic products that contain active ingredients and have medicinal benefits. Cosmeceuticals have attracted increased attention because of their beneficial effects on human health. Sea cucumbers, belonging to the class Holothuroidea, marine invertebrates, are rich in bioactive compounds, including saponin, chondroitin sulphate, collagen, amino acids, and phenols. These bioactive compounds have diverse functional roles as a secondary metabolite and these properties can be applied to the developments of novel cosmeceuticals. This review provides an overview the application of sea cucumber derivatives for cosmeceuticals. Further, prospects and trends of sea cucumber in cosmeceuticals industry were also discussed. The proper development of sea cucumber bioactive compounds will be helpful in cosmeceutical product development and industry.

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Antitumor activity of the immunomodulatory lead Cumaside

Cited by 55 publications

References 17 publications

Introduction to Anticancer Drugs from Marine Origin

Introduction to Anticancer Drugs from Marine Origin

Antitumor Activity of Cucumarioside A<sub>2</sub>-2

Cosmeceuticals Properties of Sea Cucumbers: Prospects and Trends

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