Antitumor Activity of Total Flavonoids from Daphne genkwa in Colorectal Cancer

Du, Wei; Yang, Xiaolin; Song, Zijing; Wang, Jiao-Ying; Zhang, Wenjun; He, Xin; Zhang, Runqi; Zhang, Chunfeng; Li, Fēi; Yu, Chunhao; Wang, Chong‐Zhi; Yuan, Chun‐Su

doi:10.1002/ptr.5540

Cited by 27 publications

(9 citation statements)

References 40 publications

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“…The lack of a strong association between flavonoid intake and oesophageal or colorectal cancer is particularly surprising because numerous in vitro and animal studies have demonstrated an inverse association between flavonoid and oesophageal or colorectal cancer 34 35 36 37 . However, many flavonoids present in foods cannot be absorbed in their native form, including esters, glycosides, and polymers 38 .…”

Section: Discussionmentioning

confidence: 99%

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

Bo¹,

Sun²,

Wang³

et al. 2016

Sci Rep

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Several epidemiological studies have investigated the association between dietary flavonoid intake and digestive tract cancers risk; however, the results remain inconclusive. The aim of our study was to evaluate this association. PubMed and the Web of Knowledge were searched for relevant publications from inception to October 2015. The risk ratio (RR) or odds ratio (OR) with the 95% confidence interval (95% CI) for the highest versus the lowest categories of flavonoid intake were pooled using a fixed-effects model. A total of 15 articles reporting 23 studies were selected for the meta-analysis. In a comparison of the highest versus the lowest categories of dietary flavonoid intake, we found no significant association between flavonoid intake and oesophageal cancer (OR = 0.91, 95% CI = 0.75–1.10; I2 = 0.0%), colorectal cancer (OR = 1.02, 95% CI = 0.92–1.14, I2 = 36.2%) or gastric cancer (OR = 0.88; 95% CI = 0.74–1.04, I2 = 63.6%). The subgroup analysis indicated an association between higher flavonoid intake and a decreased risk of gastric cancer in the European population (OR = 0.78, 95% CI = 0.62–0.97). In conclusion, the results of this meta-analysis do not strongly support an association between dietary flavonoid intake and oesophageal or colorectal cancer. Furthermore, the subgroup analysis suggested an association between higher dietary flavonoid intake and decreased gastric cancer risk in European population.

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Section: Discussionmentioning

confidence: 99%

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

Bo¹,

Sun²,

Wang³

et al. 2016

Sci Rep

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“…Wang et al (14) revealed that TF extracted from Cotinus coggygria exhibit potential therapeutic effect by reducing the proliferation and inducing apoptosis by regulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/ERK signaling pathway in glioblastoma cancer cells (14). The antitumor activity of TF isolated from Daphne genkwa has been analyzed in colorectal cancer, and revealed that the action of TF is likely associated with the regulation of immune function and decreased production of inflammatory cytokines (15). However, the therapeutic effects of TF in NSCLC are not well understood, particularly in terms of their in vivo anti-cancer efficacy (16).…”

Section: Introductionmentioning

confidence: 99%

Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Han

Fang

et al. 2020

Oncol Lett

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The aim of the present study was to explore the anti-cancer effects of total flavonoids (TF) on lung cancer and to investigate the underlying mechanism. The inhibitory effect of TF on the proliferation of A549 cells in vitro was measured using an MTT assay. The apoptotic rate of TF-treated A549 cells was analyzed using flow cytometry and terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling. Migration and invasion assays were performed to investigate the anti-migration effect of TF on A549 cells. Reverse-transcription quantitative PCR was used to analyze BCL2-like 2, BCL2, Bax, Bad, cyclooxygenase 2 (COX-2), Wnt and β-catenin mRNA expression levels in A549 cells. The in vivo anti-cancer effect of TF was investigated in a subcutaneous xenograft model of lung cancer in BALB/c nude mice. The results obtained in the present study revealed that TF exerted a significant inhibitory effect on the proliferation of A549 cells in a dose-dependent manner (P<0.01). TF induced apoptosis of A549 cells, which exhibited increased and decreased expression of pro-and anti-apoptotic genes, respectively. Furthermore, TF had a significant inhibitory effect on the migration and invasion of A549 cells (P<0.01). The mRNA expression levels of COX-2, Wnt and β-catenin were significantly downregulated in TF-treated A549 cells compared with controls. Additionally, treatment with TF inhibited tumor growth in mice, with a tumor inhibition rate of 64.07% compared with the controls. TF exhibited significant tumor inhibitory effects in vivo by promoting the apoptosis of tumor cells. In conclusion, the results suggested that TF may regulate lung cancer growth via the COX-2-Wnt/β-catenin signaling pathway. TF may serve as a novel anti-cancer agent for the treatment of lung cancer.

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“…De forma similar, outros estudos demonstraram que o lupeol apresentou atividade citotóxica para linhagens de câncer de mama, fígado e cólon, e pode se tornar um candidato promissor na terapia contra o câncer como medicamento, por causa da modulação na dinâmica mitocondrial, influenciando em processos que interferem na integridade da membrana, provocando apoptose. Contudo, será necessária ainda uma avaliação da posologia para aplicação em seres humanos em estudos posteriores, visto que os artigos apresentam ensaios in vitro e in vivo 28,84 .…”

Section: Discussionunclassified

Plantas Medicinais e seus Compostos com Potencial Terapêutico no Tratamento do Câncer: Revisão Integrativa

Feitoza

Terra

Grasselli

2021

Rev. Bras. Cancerol.

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Introdução: As transições epidemiológica e nutricional têm contribuído para o crescimento exponencial do câncer. Assim, com o intuito de potencializar a atividade das drogas antineoplásicas, aumentou o número de estudos utilizando plantas medicinais para tratamento do câncer. Objetivo: Identificar as plantas medicinais e os compostos com possível ação no processo de tratamento do câncer. Método: Foi realizada uma revisão integrativa. Para a busca bibliográfica, foram utilizados os descritores “neoplasias” e “plantas medicinais” e o qualificador “tratamento” para a palavra câncer, especificando-a. O levantamento dos artigos foi feito nas seguintes bases de dados: Scientific Electronic Library OnLine (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrieval Sistem Online (MEDLINE) via PubMed. Resultados: A busca e a aplicação dos critérios de inclusão e exclusão resultaram na seleção de 93 artigos. As principais características dos estudos incluídos eram ensaios in vitro, com a linhagem de células de câncer de mama e publicados em inglês. Foi possível identificar seis compostos que se destacaram em razão da sua atividade pró-apoptótica em vários tipos de câncer, a exemplo da curcumina, da epicatequina, do lupeol, do ácido cafeico, do ácido ursólico e da berberina. Conclusão: O presente trabalho oferece subsídios para que pesquisas futuras possam associar a utilização de compostos presentes em plantas medicinais ao tratamento convencional, com o intuito de melhorar o prognóstico de pacientes oncológicos.

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Antitumor Activity of Total Flavonoids from Daphne genkwa in Colorectal Cancer

Cited by 27 publications

References 40 publications

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

Dietary flavonoid intake and the risk of digestive tract cancers: a systematic review and meta-analysis

Total flavonoids suppress lung cancer growth via the COX‑2‑mediated Wnt/β‑catenin signaling pathway

Plantas Medicinais e seus Compostos com Potencial Terapêutico no Tratamento do Câncer: Revisão Integrativa

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