Antitumor Agents. 49. Tricin,Kaempferol-3-0-β-D-Glucopyranoside and (+)-Nortrachelogenin, Antileukemic Principles From Wikstroemia indica

Abstract

Bioassay-directed isolation of the antitumor extract of Wikstroemia indica (Thymelaeaceae) has led to the characterization of tricin, kaempferol-3-O-beta-D-glucopyranoside, and (+)-nortrachelogenin as the major antileukemic constituents. In addition, daphnoretin was identified as the potent antitumor principle in vivo against the Ehrlich ascites carcinoma growth in mice.

Growth-inhibitory and cell cycle-arresting properties of the rice bran constituent tricin in human-derived breast cancer cells in vitro and in nude mice in vivo

“…It interfered potently with the growth of human-derived malignant MDA-MB-468 breast cancer cells, and was much less growthinhibitory in HBL-100 cells, nonmalignant but transformed human breast cells (Hudson et al, 2000). In 1981 tricin was characterised in the plant Wikstroemia indica as a constituent with antileukemic properties in rodents (Lee et al, 1981). It needs to be pointed out though that the potential contribution of dietary tricin to the low incidence of cancer of the breast, colon or prostate in Asia as compared to the West is difficult to reconcile with its occurrence in cereal grains such as wheat, corn and barley, which are consumed in large amounts in the West.…”

Chemical compositions extracted fromWikstroemia indicaand their multiple activities

“…The therapeutic potentialities of W. indica, such as antiinflammatory (Wang et al, 2005a), antiviral (Hu et al, 2000), antitumor (Lee et al, 1981;Hu et al, 2000) and antimalarial activities (Nunome et al, 2004), have already been investigated. However, there isn't any report about the antimicrobial activities of the flavonoids from W. indica.…”

Novel antitumor agents from higher plants

“…infected mice. 65 Synthetic 2-phenyl-4-quinolones (e.g., 62-65) contain a ring nitrogen instead of the oxygen found in the natural compounds and showed promising cytotoxic activity. 66 In a series of 3Ј,6,7-substituted compounds, 67 several compounds, including 62 and 63, showed impressive differential cytotoxicity against human tumor cell lines and were potent inhibitors of tubulin polymerization with activity nearly comparable to those of the potent antimitotic natural products colchicine (86), podophyllotoxin (14), and combretastin A-4.…”