Antitumor Agents XXXVIII: Isolation and Structural Elucidation of Novel Germacranolides and Triterpenes from Elephantopus mollis

Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth.

“…Its reputed efficacies as anticancer and antidiabetes remedies have been respectively verified by Rajkapoor et al (2002) and Daisy et al (2009) in in vivo animal models. Further in vitro antiproliferative assays have led to an emphasis on the cytotoxic effect of sesquiterpene lactones isolated from the species (Lee et al, 1975;Lee et al, 1980;Than et al, 2005;Tabopda et al, 2008) with induction of apoptosis towards human cervical carcinoma HeLa and neuroblastoma B104 cells (Xu et al, 2006;Tabopda et al, 2008). The apoptotic property of its sesquiterpene lactone (isodeoxyelephantopin) was also found to enhance the antiinflammatory effect by suppressing Nuclear Factor-B (NF-B) gene expression (Ichikawa et al, 2006).…”

Antitumor Agents, 71. Nudaphantin, a New Cytotoxic Germacranolide, and Elephantopin from Elephantopus nudatus

“…One of these was due to the lactonic carbonyl; the other was from an ester which was also indicated by an ir band at 1715 cm-1. The comparable nmr peaks and splitting pattern between 1 and the two C-8 -substituted methylacrylate ester side chain bearing 2 (l)4 and molephantin (8)3 led to the assignment of this same ester side chain for 1. Thus, the broad three proton singlet at 61.94, and two low-field multiplets at 65.69 and 6.16 were assigned to H-18, H-19, and H-19, respectively.…”

Cytotoxic and Apoptotic Effects of Ethyl Acetate Extract of Elephantopus mollis Kunth. in Human Liver Carcinoma HepG2 Cells Through Caspase-3 Activation

“…Several sesquiterpene lactones isolated from its extracts were discovered to be the main contributors to its in vitro cytotoxic activity. [13][14][15][16] However, to date, cytotoxic assessment to determine the combined effect of various compounds in its therapeutic decoction, infusion, and herbal soup 17 has yet to be performed. Therefore, in this study, the cytotoxic activity of its decoction was compared with the extracts obtained through quantitative recovery procedure (using sequential extraction with 3 different polarities of solvents).…”