Antitumor and antiplatelet activity of alkaloids from <i>veratrum dahuricum</i>

Tang, Jian; Li, Hui‐Liang; Shen, Yun‐Heng; Jin, Hui‐Zi; Yan, Shaomin; Liu, Xiaohua; Zeng, Hua‐Wu; Liu, Runhui; Tan, Ye-Xiong; Zhang, Wei‐Dong

doi:10.1002/ptr.3022

Cited by 36 publications

(17 citation statements)

References 13 publications

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“…Traditional Chinese medicine has relatively fewer side-effects and has been used to treat various diseases in clinical medicine, including cancer, for numerous years (18–22). As a well-known traditional Chinese medicine, Veratrum has shown significant anticancer effects in a variety of carcinomas (14–16). …”

Section: Discussionmentioning

confidence: 99%

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Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Wang

Zhang

et al. 2013

Oncology Letters

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Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine, Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF-7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism-related genes. The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA-mediated apoptosis of HeLa, HepG2 and MCF-7 cells.

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Section: Discussionmentioning

confidence: 99%

“…Previous research has shown that Veratrum significantly inhibits the growth of human leukemia HL-60, human gastric carcinoma BGC-823, human liver carcinoma BEL-7402 and human nasopharyngeal carcinoma KB (14–16) cells.…”

Section: Introductionmentioning

confidence: 97%

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Wang

Zhang

et al. 2013

Oncology Letters

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“…Previous phytochemical and pharmacological investigations have shown that the main active components of the genus Veratrum are the steroidal alkaloids . Moreover, some of them possessed anti-hypertensive (Krayer and Meilman, 1977), antiplatelet (Tang et al, 2010), and antitumor activities as well as teratogenic toxicity (Hovhannisyan et al, 2009). Especially, cyclopamine analogues have been regarded as the research hotspot in antitumor drugs due to inhibition of the Hedgehog signaling pathway (Tremblay et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense

Yang

Zhao

et al. 2016

Journal of Ethnopharmacology

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“…Recently, our partners have synthesized 93 cyclopamine derivatives and their activities were tested against four different cell lines (BxPC-3, NCI-H446, SW1990 and NCI-H157) respectively [7][8]. Based on these experimental data, a systematical QSAR investigation was carried out by incorporation of various statistic modelings and different molecular descriptors [7].…”

Section: Introductionmentioning

confidence: 99%

Integrated QSAR study for inhibitors of hedgehog signal pathway against multiple cell lines:a collaborative filtering method

et al. 2012

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BackgroundThe Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to the functioning of the pathway are in a great demand. As the matter of fact, effective inhibitors could provide efficient therapies for a wide range of malignancies, and targeting such pathway in cells represents a promising new paradigm for cell growth and death control. Current research mainly focuses on the syntheses of the inhibitors of cyclopamine derivatives, which bind specifically to the Smo protein, and can be used for cancer therapy. While quantitatively structure-activity relationship (QSAR) studies have been performed for these compounds among different cell lines, none of them have achieved acceptable results in the prediction of activity values of new compounds. In this study, we proposed a novel collaborative QSAR model for inhibitors of the Hedgehog Signaling Pathway by integration the information from multiple cell lines. Such a model is expected to substantially improve the QSAR ability from single cell lines, and provide useful clues in developing clinically effective inhibitors and modifications of parent lead compounds for target on the Hedgehog Signaling Pathway.ResultsIn this study, we have presented: (1) a collaborative QSAR model, which is used to integrate information among multiple cell lines to boost the QSAR results, rather than only a single cell line QSAR modeling. Our experiments have shown that the performance of our model is significantly better than single cell line QSAR methods; and (2) an efficient feature selection strategy under such collaborative environment, which can derive the commonly important features related to the entire given cell lines, while simultaneously showing their specific contributions to a specific cell-line. Based on feature selection results, we have proposed several possible chemical modifications to improve the inhibitor affinity towards multiple targets in the Hedgehog Signaling Pathway.ConclusionsOur model with the feature selection strategy presented here is efficient, robust, and flexible, and can be easily extended to model large-scale multiple cell line/QSAR data. The data and scripts for collaborative QSAR modeling are available in the Additional file 1.

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Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum

Cited by 36 publications

References 13 publications

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Potent anti-inflammatory and analgesic steroidal alkaloids from Veratrum taliense

Integrated QSAR study for inhibitors of hedgehog signal pathway against multiple cell lines:a collaborative filtering method

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