Antitumor and hepatoprotective activity of natural and synthetic neo steroids

Dembitsky, Valery M.

doi:10.1016/j.plipres.2020.101048

Cited by 33 publications

(36 citation statements)

References 140 publications

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“…It is known that sulfated steroids are of potential interest for practical and clinical medicine, due to the fact that many of them exhibit a wide range of biological activities; however, the activity of many sulfated steroids has not been determined [ 2 , 9 , 10 , 15 , 16 , 17 , 18 , 21 , 46 ].…”

Section: Mono Sulfated Steroids Derived From Marine Sourcesmentioning

confidence: 99%

“…Sulfur is one of the most abundant chemical elements in nature [ 1 , 2 ]. In addition, sulfur is found in many classes of organic compounds such as peptides, various terpenoids and steroids, and other compounds [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. More than 3000 different sulfur compounds are found in various ecological niches, including oceans and freshwater lakes, volcanic gases, sediments, and rocks [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Sulfate is generally readily available in aquatic ecosystems for many marine and freshwater organisms [ 1 , 2 , 3 , 4 , 9 , 10 , 14 , 18 , 20 , 23 , 24 , 25 , 26 , 27 ]. The biochemistry and geochemistry of sulfur are currently well studied, and many publications are devoted to this topic [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , …”

Section: Introductionmentioning

confidence: 99%

“…Sulfated compounds, including steroids, are widely distributed in nature [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Sulfated steroids and triterpenoids are found in many animals, reptiles, and humans [ 9 , 10 , 11 , 12 , 13 , 14 ]. In addition, these compounds are present in extracts of plants and some shrubs, produced by microorganisms, fungi, and found in many marine invertebrates such as brittle star, starfish, sponges, ascidian, snails, and algae [ 2 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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The review focuses on sulfated steroids that have been isolated from seaweeds, marine sponges, soft corals, ascidians, starfish, and other marine invertebrates. Sulfur-containing steroids and triterpenoids are sourced from sedentary marine coelenterates, plants, marine sediments, crude oil, and other geological deposits. The review presents the pharmacological profile of sulfated steroids, sulfur-containing steroids, and triterpenoids, which is based on data obtained using the PASS program. In addition, several semi-synthetic and synthetic epithio steroids, which represent a rare group of bioactive lipids that have not yet been found in nature, but possess a high level of antitumor activity, were included in this review for the comparative pharmacological characterization of this class of compounds. About 140 steroids and triterpenoids are presented in this review, which demonstrate a wide range of biological activities. Therefore, out of 71 sulfated steroids, thirteen show strong antitumor activity with a confidence level of more than 90%, out of 50 sulfur-containing steroids, only four show strong antitumor activity with a confidence level of more than 93%, and out of eighteen epithio steroids, thirteen steroids show strong antitumor activity with a confidence level of 91% to 97.4%.

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Section: Mono Sulfated Steroids Derived From Marine Sourcesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

et al. 2021

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“…Gonan core may be saturated or partially unsaturated and contain alkyl groups and some functional groups including hydroxyl, carbonyl, or carboxyl. Steroids possess a variety of pharmacological effects including antitumor activity [138].…”

Section: Steroids and Ergosterolsmentioning

confidence: 99%

Bioactive Compounds With Antiglioma Activity From Marine Species

Khotimchenko

Bryukhovetskiy

Khotimchenko

2021

Preprint

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The search for new chemical compounds with antitumor pharmacological activity is a necessary process for creating more effective drugs for each specific malignancy type. This review presents the outcomes of screening studies of natural compounds with high anti-glioma activity. Despite significant advances in cancer therapy, there are still some tumors currently considered completely incurable including brain gliomas. This review covers the main problems of the glioma chemotherapy including drug resistance, side effects of common anti-glioma drugs, and genetic diversity of brain tumors. The main emphasis is made on the characterization of natural compounds isolated from marine organisms because taxonomic diversity of organisms in seawaters significantly exceeds that of terrestrial species. Thus, we should expect greater chemical diversity of marine compounds and greater likelihood of finding effective molecules with antiglioma activity. The review covers at least 15 classes of organic compounds with their chemical formulas provided as well as semi-inhibitory concentrations, mechanisms of action, and pharmacokinetic profiles. In conclusion, the analysis of the taxonomic diversity of marine species containing bioactives with antiglioma activity is performed noting cytotoxicity indicators and to the tumor cells in comparison with similar indicators of antitumor agents approved for clinical use as antiglioblastoma chemotherapeutics.

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Acremocholone, an Anti‐Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge‐Associated Fungus Acremonium sp. NBUF150

Feng

Wang

et al. 2022

Chemistry & Biodiversity

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Mesophotic coral ecosystems (MCEs) represent an underexplored source of intriguing natural products. Efforts to discover bioactive metabolites from sponge‐associated fungi in MCEs identified a new steroid, acremocholone (1) and its three known analogs (2–4), from Acremonium sp. NBUF150. The Acremonium sp. NBUF150 was isolated from a Ciocalypta sponge located 70 m deep within the South China Sea. The planar structures and absolute configuration of 1–4 were determined from NMR‐derived spectroscopic data, HR‐ESI‐MS, and X‐ray crystallography. Compound 1 exhibited antimicrobial inhibition against Vibrio scophthalmi, V. shilonii and V. brasiliensis at minimum inhibitory concentrations of 8 μg/mL; compound 2 inhibited V. shilonii and V. brasiliensis at 8 and 32 μg/mL, respectively, and compound 4 inhibited growth of V. brasiliensis at 16 μg/mL. Sponge associated fungi from MCEs represent a promising resource of anti‐Vibrio drug leads for aquaculture use.

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Antitumor and hepatoprotective activity of natural and synthetic neo steroids

Cited by 33 publications

References 140 publications

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile

Bioactive Compounds With Antiglioma Activity From Marine Species

Acremocholone, an Anti‐Vibrio Steroid from the Marine Mesophotic Zone Ciocalypta Sponge‐Associated Fungus Acremonium sp. NBUF150

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