Antitumor and immunomodulating activities of the polysaccharide fractions fromArtemisia selengensis andArtemisia iwayomogi

Koo, Kyoung Ah; Kwak, Jong Hwan; Lee, Kang Ro; Zee, Ok Pyo; Woo, Eun Rhan; Park, Ho Kun; Youn, Heejung

doi:10.1007/bf02974179

Cited by 35 publications

(44 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 1b showed that the yield of polysaccharides increased significantly with increasing extraction temperature, and then decreased gradually when the temperature was over 50°C. The higher temperature could improve the leaching rate of extracted polysaccharides (Koo et al 1994). However, with the synergistic effect of high temperature and ultrasonic, the polysaccharide structure was easier to be destroyed.…”

Section: Effects Of Extraction Temperature On Polysaccharides Yieldmentioning

confidence: 99%

“…The average molecular weight values of APS1 and APS2 were estimated to be 125.4 and 184.1 kDa, respectively. It has been reported that the molecular weight of the one polysaccharide from Artemisiae species was 2500 Da (Koo et al 1994). However, our results were quite different from the previous study, which indicated the larger molecular weights of APS1 and APS2.…”

Section: Comparison Between Uae and Csementioning

confidence: 99%

“…As a group of biologically active compositions, polysaccharides are well-known for their health-beneficial functions attributed to their anti-oxidant and anti-cancer activities (Li et al 2014a, b, c;Wu et al 2013). Although it has been reported that bioactive compositions from water extraction of AST contained abundant of polysaccharides compounds (Zhang et al 2014), and polysaccharides isolated from AST were also previously demonstrated to have immunomodulatory and antitumor activities (Koo et al 1994), there are very limited researches about extraction of polysaccharides from AST, as well as the components and bioactivity of extracts.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Wang

Umair

et al. 2016

J Food Sci Technol

View full text Add to dashboard Cite

Artemisia selengensis Turcz (AST) is a perennial herb with therapeutic and economic applications in China. The effects of ultrasound-assisted extraction (UAE) parameters upon extraction yield (EY%), antioxidant and antitumor activities of the polysaccharides extracts were studied by using a factorial design and response surface methodology. The optimal conditions determined were as: ultrasonic power 146 W, extraction time 14.5 min. and extraction temperature 60°C. The average molecular weights of two homogeneous polysaccharides (APS1 and APS2) purified by DEAE cellulose-52 and Sephadex G-100 column chromatography were 125.4 and 184.1 kDa, respectively. Monosaccharide analysis showed that APS1 and APS2 were composed of five common monomers i.e., galactose, mannose, arabinose, xylose and rhamnose and one different monomer glucose and galacturonic acid respectively, with a most abundant part in molar % of APS1 and APS2 were glucose (83.01 %) and galacturonic acid (48.87 %) while least were xylose (0.80 %) and mannose (1.73 %) respectively. The antioxidant properties were determined by evaluating DPPH, hydroxyl radical scavenging activity and reducing power which indicated both APS1 and APS2 showed strong scavenging activities and anticancer activities on HT-29, BGC823 and antitumor activity on HepG-2. As UAE improved the polysaccharides yield than CSE, meanwhile, no significant difference of polysaccharides chemical compositions. Therefore, the present study suggests that the consumption of AST leaves may beneficial for the treatment of many diseases.

show abstract

Section: Effects Of Extraction Temperature On Polysaccharides Yieldmentioning

confidence: 99%

Section: Comparison Between Uae and Csementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Wang

Umair

et al. 2016

J Food Sci Technol

View full text Add to dashboard Cite

show abstract

“…This extract is known to have anti-tumor and immune-modulating activities [106]. 8 proteins were regulated in DCs after exposure to AIP1.…”

Section: Dcs Upon Immunomodulationmentioning

confidence: 99%

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

Ferreira

Mathieu

Overbergh

2010

Proteomics Clinical Apps

View full text Add to dashboard Cite

Dendritic cells (DC) have always been present on the bright spot of immune research. They have been extensively studied for the last 35 years, and much is known about their different phenotypes, stimulatory capacity, and role in the immune system. During the last 15 years, great attention has been given to studies on global gene and protein expression profiles during the differentiation and maturation processes of these cells. It is well understood that studying the proteome, together with information on the role of protein post-translational modifications (PTM), will reveal the real dynamics of a living cell. The rapid increase of proteomic studies during the last decade describing the differentiation and maturation process in DCs, as well as modifications brought by the use of different compounds that either increase or decrease their immunogenicity, reflects the importance of understanding the molecular processes behind the functional properties of these cells. In the present review, we will give an overview of proteomic studies focusing on DCs. Thereby we will concentrate on the importance of these studies in understanding DC behavior from a molecular point of view and how these findings have aided in understanding the differences in functional properties of these cells.

show abstract

“…5 In another study, AIP1, a water-soluble carbohydrate fraction from A. iwayomogi, showed anti-tumor and immunomodulating activities. 6 In addition, the aqueous extract of A. iwayomogi prevented the immediate-type allergic reaction and inflammatory cytokine secretion in mast cells. 7 As a part of our ongoing search for bioactive compounds from natural products, one new diterpene glycoside (1), named iwayoside A, together with two monoterpenes, unshuoside A (2) and α-terpinyl-O-β-D-glucoside (3), were isolated from the aerial parts of A. iwayomogi.…”

mentioning

confidence: 98%

Iwayoside A, a New Diterpene Glycoside from Artemisia iwayomogi Kitamura that Enhances IL-2 Secretion

Ding¹,

Liang²,

Yang³

et al. 2010

Bulletin of the Korean Chemical Society

View full text Add to dashboard Cite

Antitumor and immunomodulating activities of the polysaccharide fractions fromArtemisia selengensis andArtemisia iwayomogi

Cited by 35 publications

References 7 publications

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

Iwayoside A, a New Diterpene Glycoside from Artemisia iwayomogi Kitamura that Enhances IL-2 Secretion

Contact Info

Product

Resources

About