Antitumor and Immunomodulatory Activity of P leurotus eryngii Extract

Abstract

Pleurotus eryngii (P. eryngii), also known as the king oyster mushroom, contains many bioactive substances, including polysaccharides, lipids, peptides, sterols and triterpenoids. The aim of this study was to explore the antitumor and immunomodulatory activities of P. eryngii extract. The fresh P. eryngii material was extracted with MeOH (methanol) and then partitioned with EtOAc (ethyl acetate). The study showed that the P. eryngii EtOAc extract (EAe) not only has antitumor effects by in vitro and in vivo methods but also significantly increases some immune activities. In addition, histopathological observations showed that EAe‐treated mice exhibited much lower cancerization throughout the liver and lung. EAe can also promote antioxidant activity, which may regulate the body's antioxidant capacity and activate the antitumor mechanism. Practical Applications Our study revealed the anticancer and immunomodulatory activity of Pleurotus eryngii extract, and identified the key components of the P. eryngii extract with HPLC‐MS. These findings explain the antitumor activity of P. eryngii, which is very useful for developing the potential antitumor drugs for clinical application.

Preparation of newly identified polysaccharide from Pleurotus eryngii and its anti‐inflammation activities potential

“…Pleurotus eryngii , also known as king oyster mushroom, is commonly consumed as an edible mushroom around the world with multiple nutrition functional activities including antitumor (Xue et al., 2015), antioxidant (Choi, Kim, Kim, & Kim, 2017), antihypertensive (Khan & Tania, 2012), antimicrobial (Adebayo et al., 2018), immunomodulatory (Corrêa, Brugnari, Bracht, Peralta, & Ferreira, 2016), and anti‐inflammatory activities (Lin et al., 2014) among others. Its activities have been proven to be related to the abundance and diversity of active components.…”

Multi-Pesticide Residue Analysis Method Designed for the Robot Experimenters

“…Although Z-Spe could efficiently remove phospholipid interferents, it produced excessive adsorption of 53 pesticides. In onion, apricot mushroom, and pakchoi samples, small-molecule components mainly include organic acids, amino acids, vitamins, sugars, phenolic compounds, and pigments. − In addition, polyphenols and alkaloids are special interferents in tea samples. , Based on the above-mentioned consideration, a mixture of PSA, C18, CarbonX, and MgSO 4 was used in this study. PSA is widely applied in the QuEChERS method to remove polar interferents such as sugars and organic acids from the matrix .…”

Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products

“…Similarly, a recent report showed that an aqueous extract of Sarcodon imbricatus (SIE) effectively inhibited the growth, migration, and invasion properties of breast cancer cells in vitro and reduced tumor growth in vivo, while showing increased expression of PD-L1 and increased NK cell viability [152]. Furthermore, Xue et al reported that a triterpenoid EAe from Pleurotus eryngii inhibited MCF-7 cell lines proliferation with an EC50 of 298.26 µg/mL, and significantly inhibited the growth of CD-1 tumors (inhibition rate of 65%) in mice in a dose-dependent manner without toxicity [153].…”