Antitumor Antibodies and Immunoglobulin Class and Subclass Levels in Corynebacterium Parvum -Treated Mice

Abstract

Changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with Corynebacterium parvum. C. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially Ig G2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. The serologic changes induced by C. parvum were dependent on the dose and route of administration; preliminary studies suggested that they may have been largly independent of T-cell function. These changes were suppressed by the administration of gold salts, which also inhibited the antitumor effect of C. parvum.

Serological changes in adjuvant-treated mice, their specificity and relevance to tumor immunity

“…shown that the administration of C. parvum to both mouse and man results in a marked increase in the levels of certain immunoglobulin classes and subclasses (James et al, 1975;James et al, 1976). Furthermore, this treatment in mice is accompanied by an increase in the levels of circulating immunoglobulin capable of binding to tumor cells in vitro .…”

Association of host immunoglobulins with solid tumours in vivo

“…Thus, whilst C. parvum therapy consistently caused a significant increase in the levels of tumour IgA and IgM, it rarely elicited a significant increase in IgG2a and IgG2b. These effects contrast with those observed with respect to serum immunoglobulin levels were the same C. parvumn protocol increases the level of all classes and subclasses, but especially IgG2a and IgG2b (James et al, 1976;1977). Whilst these differences suggest selective binding or local production of certain immunoglobulins by infiltrating host cells, these possibilities have still to be investigated.…”

“…4). However, differences in the 16-3+ 6-9 ;ted 102-3 + 38-9 6-3 + 0-9 4-9+0-9 4-3 + 0-8 5-5+0-9 2-3+0-6 2-9+0-1 2-6+0-1 2 4 + 02 2-5+0-3 2-1+0-2 3-7+0-3 16-2+2-0 6-6+0-8 15-8 + 1-0 7-6 + 1-7 12-6 + 2-0 6-8 + 1-0 13-8+2-0 5-8+0-8 12-4+1-1 <1 10-8+0-7 6-1+0-9 105+0-8 <1 10-0+0-9 <1 9-1+0-9 <1 10-7+ 1-1 James et al, 1976). Experiments were therefore performed to ascertain whether C. parvum treatment might influence the amount of immunoglobulin associated with solid tumours in vivo.…”

Antigenic Relationship between Streptococcal Preparation OK-432 and Tumors and Its Effect on Immunotherapy with OK-432 in Patients with Superficial Bladder Tumor

“…It has been reported that BCG shares com mon antigens with a number of different tumor cells including guinea pig hepatoma, Rous sarcoma and hu man melanoma [10][11][12][13][14][15]. Antigens common to C. par vum and to 3-methylcholanthrene-induced fibrosarcoma in mice have been described [16]. Shared antigenicity between the purified line-10 guinea pig hepatoma and BCG has also been reported [17,18].…”