Antitumor drug effect of betulinic acid mediated by polyethylene glycol modified liposomes

Liu, Yanping; Gao, Dawei; Zhang, Xuwu; Liu, Zhiwei; Keino, Dai; Ji, Bingshuo; Wang, Qianqian; Luo, Liyao

doi:10.1016/j.msec.2016.03.080

Cited by 66 publications

(42 citation statements)

References 36 publications

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“…However, PSLs can be rapidly eliminated from the blood because of their affinity for mononuclear phagocytes, and the short half‐life of PSLs limits their application as drug‐delivery systems. To address the latter challenge, a technique for modifying the surface of liposomes with polyethylene glycol (PEG) has been developed . PEGylation disrupted the binding interaction between plasma proteins and liposomes, thereby inhibiting their recognition and elimination from the blood by phagocytosis .…”

Section: Introductionmentioning

confidence: 99%

“…To address the latter challenge, a technique for modifying the surface of liposomes with polyethylene glycol (PEG) has been developed. 15,16 PEGylation disrupted the binding interaction between plasma proteins and liposomes, thereby inhibiting their recognition and elimination from the blood by phagocytosis. 17 Previous studies demonstrated that PEGylated liposomes can persist in the circulation for longer periods of time than non-PEGylated liposomes.…”

Section: Introductionmentioning

confidence: 99%

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Modulation of the anti‐inflammatory effects of phosphatidylserine‐containing liposomes by PEGylation

Quan

Park

Kim

et al. 2017

J Biomedical Materials Res

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Inhibiting liposome uptake by macrophages using polyethylene glycol (PEG) surface modifications is a widely used approach for extending the half-life of liposomes circulating in the blood. However, the biological effects of PEGylated liposomes on macrophages have not yet been thoroughly investigated. The purpose of this study was to examine the effects of PEGylated phosphatidylserine-containing liposomes (PEG-PSLs) on the expression of two inflammation-associated cytokines, tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β), in the murine macrophage-like cell line RAW 264.7. Previous studies have demonstrated that PSLs inhibit TNF-α secretion and enhance TGF-β synthesis in macrophages by mimicking apoptotic cells. We found that PEGylation differentially affected the TNF-α and TGF-β levels. The PSL-mediated inhibitory effect on TNF-α secretion was enhanced by PEGylation, and PEG-PSLs decreased TGF-β levels compared with non-PEGylated PSLs. Fluorescence-activated cell sorting analysis demonstrated that 1% PEGylation disturbed the incorporation of PSLs into macrophages. The interference of uptake is thought to extend the binding interaction between PS to PS receptors for PSL-mediated inhibition of TNF-α expression. Together, these findings indicate that PEG-PSLs can prevent TNF-α secretion without increasing TGF-β levels in macrophages, and they support the potential clinical use of PEG-PSLs as anti-inflammatory agents with a relatively low potential to induce tissue fibrosis. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1479-1486, 2017.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modulation of the anti‐inflammatory effects of phosphatidylserine‐containing liposomes by PEGylation

Quan

Park

Kim

et al. 2017

J Biomedical Materials Res

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“…Konjugasi liposom dengan PEG bertujuan untuk meningkatkan lama waktu paruh, meningkatkan solubilitas, serta dapat menghindarkan modalitas dari degradasi oleh RES dan sistem imun sehingga meningkatkan efektivitas dari modalitas. 51,52 Pembuatan kombinasi ini dimulai dengan menggunakan metode thin lipid film hydration yang termodifikasi. 53…”

Section: Review Articleunclassified

Combination of Cisplatin-Withaferin Based on PEGylated Liposome Nanoparticles as Alternative Therapy for Ovarian Cancer

Yani

Anjani

Narayana

et al. 2020

JMH

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Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review's goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through β-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer. AbstrakKanker ovarium merupakan masalah kesehatan ginekologi wanita di dunia. Data Global Burden Cancer (Globocan) tahun 2012 menunjukkan kanker ovarium terjadi sebanyak 239.000 kasus, dan menempati urutan ke-empat di Indonesia. Hingga kini, Cisplatin merupakan agen terapi andalan untuk kanker ovarium namun sering menimbulkan efek samping dalam dosis tinggi. Terapi alternatif dapat menjadi solusi untuk mengatasi masalah tersebut dengan memanfaatkan withaferin A (WFA) serta nanopartikel PEGylated liposome. WFA sangat potensial untuk mengurangi resistensi Cisplatin, tetapi memiliki bioavailabilitas rendah sehingga perlu dienkapsulasi. Tujuan tinjauan ini yaitu untuk menggambarkan potensi kombinasi withaferin A, cisplatin, dan PEGylated liposome sebagai pengobatan untuk kanker ovarium. Tinjauan pustaka ini dilakukan dengan menggunakan kata: "kanker ovarium, Withaferin A, Cisplatin dan PEGylated liposome" sebagai kata kunci pada mesin pencarian. Kombinasi Cisplastin-Withaferin dan nanopartikel PEGylated Liposom dilakukan dengan metode thin lipid film hydration yang termodifikasi kemudian diberikan melalui jalur oral. Kombinasi Cisplastin-Withaferin ini dapat menekan pertumbuhan kanker ovarium sebesar 70-80% secara in vivo, menghambat NGFR berikatan dengan TRKA sehingga mencegah terjadinya migrasi sel sebesar 50%, menghambat migrasi sel kanker secara signifikan melalui jalur persinyalan β-catenin oleh ALDH1, meningkatkan apoptosis sebesar 70-80% melalui peningkatan produksi ROS hingga 2,5 kali lipat, serta mampu mengeliminasi CSC. Karena itu, kombinasi ini merupakan salah satu terapi potensial dalam penatalaksanaan kanker ovarium. Kata kunci: Cisplatin; kanker ova...

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“…In another study, Liu et al . developed a polyethylene glycol–modified (PEGylated) BA liposome delivery system using an ethanol injection technique . The grafting of PEG onto the surface of liposomes was performed in order to prolong blood circulation times.…”

Section: Nanoformulations For Betulinic Acid Deliverymentioning

confidence: 99%

Therapeutic applications of betulinic acid nanoformulations

Saneja

Arora

Kumar

et al. 2018

Annals of the New York Academy of Sciences

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Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad-spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half-life in vivo, which limit therapeutic application. To solve these problems, much work in recent years has focused on enhancing BA's aqueous solubility, half-life, and efficacy by using nanoscale drug delivery systems. Several different kinds of nanoscale delivery systems-including polymeric nanoparticles, magnetic nanoparticles, liposomes, polymeric conjugates, nanoemulsions, cyclodextrin complexes, and carbon nanotubes-have been developed for the delivery of BA. Here, we focus on the recent developments of novel nanoformulations used to deliver BA in order to improve its efficacy.

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Antitumor drug effect of betulinic acid mediated by polyethylene glycol modified liposomes

Cited by 66 publications

References 36 publications

Modulation of the anti‐inflammatory effects of phosphatidylserine‐containing liposomes by PEGylation

Modulation of the anti‐inflammatory effects of phosphatidylserine‐containing liposomes by PEGylation

Combination of Cisplatin-Withaferin Based on PEGylated Liposome Nanoparticles as Alternative Therapy for Ovarian Cancer

Therapeutic applications of betulinic acid nanoformulations

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