Antitumor effect of avermectins

Drinyaev, V. A.; Mosin, V A; Kruglyak, E. B.; Novik, T. S.; Sterlina, Tatiana S.; Ermakova, N V; Kublik, L. N.; Levitman, M. Kh.; Shaposhnikova, V. V.; Korystov, Yuri N.

doi:10.1016/j.ejphar.2004.08.009

Cited by 44 publications

(38 citation statements)

References 3 publications

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“…The use of ivermectin, a broad-spectrum antiparasitic drug, has now been extended to multiple disease models (14,33). Recently, this antiparasitic drug has been proposed as a promising anticancer agent in several types of cancer due to its remarkable ability to inhibit tumor growth (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, ivermectin, an avermectin derivative, was chemically modified and found to be a more effective compound against a variety of parasites (13). Recently, ivermectin has been identified as a promising anticancer agent for colon cancer, ovarian cancer, melanoma, and leukemia (14)(15)(16)(17). However, the detailed molecular mechanisms underlying ivermectin-mediated suppression of tumor growth remain to be further elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

et al. 2016

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Breast cancer is the most common cancer among women worldwide, yet successful treatment remains a clinical challenge. Ivermectin, a broad-spectrum antiparasitic drug, has recently been characterized as a potential anticancer agent due to observed antitumor effects. However, the molecular mechanisms involved remain poorly understood. Here, we report a role for ivermectin in breast cancer suppression by activating cytostatic autophagy both in vitro and in vivo. Mechanistically, ivermectin-induced autophagy in breast cancer cells is associated with decreased P21-activated kinase 1 (PAK1) expression via the ubiquitinationmediated degradation pathway. The inhibition of PAK1 decreases the phosphorylation level of Akt, resulting in the blockade of the Akt/mTOR signaling pathway. In breast cancer xenografts, the ivermectin-induced cytostatic autophagy leads to suppression of tumor growth. Together, our results provide a molecular basis for the use of ivermectin to inhibit the proliferation of breast cancer cells and indicate that ivermectin is a potential option for the treatment of breast cancer. Cancer Res; 76(15); 4457-69. Ó2016 AACR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

et al. 2016

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“…The ratio of females to males was lower than the control (0.937). It is very interesting to note that inhibition of fertility of aversectin C was also reported in connection with its possible anticancer effects [20]. Germ cells like a cancer cells are under process of genome rejuvenation: therefore, if a compound reduces fertility, it also will demonstrate anticancer effect [21,22].…”

Section: Discussionmentioning

confidence: 99%

The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster

Trushin¹,

Khamidullina²,

Ardashov³

et al. 2017

mpj

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Adequate treatment of Parkinson's disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster.Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila.. Key words:Parkinson's disease; fertility; drosophila; (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; acetate; terpene.

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“…The avermectins are known to possess pronounced antitumor activity, 107 as well as the ability to potentiate the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine-resistant strain P388. 108 Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties.…”

Section: Anti-cancermentioning

confidence: 99%

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

2017

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Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

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Antitumor effect of avermectins

Cited by 44 publications

References 3 publications

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer

The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

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