Antitumor effect of new local hyperthermia using dextran magnetite complex in hamster tongue carcinoma

Wada, Shigehito; Tazawa, Kenji; Furuta, Isao; Nagae, Hideo

doi:10.1034/j.1601-0825.2003.02839.x

Cited by 43 publications

(17 citation statements)

References 12 publications

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“…Hematite nanoparticles, crystallizing in the rhombohedral system and showing a weak ferromagnetic behavior at room temperature [1], have been extensively used as catalyst [2,3], pigment [4], gas sensor [5], optical devices [6], and medicine applications [7]. Magnetite and maghemite, instead, crystallizing in the cubic crystal system and with a ferromagnetic behavior at room temperature, have been widely exploited in technological applications including information storage [8], sensors [9], refrigeration [10], and coil cores [11], as well as in contrast agent for magnetic resonance imaging [12,13], and potential mediator for magnetic hyperthermia [14].…”

Section: Introductionmentioning

confidence: 99%

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Russo

Acierno

Palomba

et al. 2012

Journal of Nanotechnology

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Magnetite (Fe 3 O 4 ) nanoparticles prepared by microwave-assisted hydrothermal synthesis have been characterized in terms of morphological and structural features. Electron micrographs collected in both scanning (SEM) and transmission (TEM) modes and evaluations of X-ray powder diffraction (XRD) patterns have indicated the achievement of a monodispersed crystallite structure with particles having an average size around 15-20 nm. Structural investigations by Micro-Raman spectroscopy highlighted the obtainment of magnetite nanocrystals with a partial surface oxidation to maghemite (γ-Fe 3 O 4 ). Preliminary attention has been also paid to the use of these magnetite nanoparticles as filler for a commercial polymethylmethacrylate resin. Hybrid formulations containing up to 3 wt% of nanoparticles were prepared by melt blending and characterized by calorimetric and thermogravimetric tests. For sake of comparison, same formulations containing commercial Fe 3 O 4 nanoparticles are also reported. Calorimetric characterization indicates an increase of both glass transition temperature and thermal stability of the nanocomposite systems when loaded with the synthesized magnetite nanoparticles rather then loaded with the same amount of commercial Fe 3 O 4 . This first observation represents just one aspect of the promising potentiality offered by the novel magnetic nanoparticles when mixed with PMMA.

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Section: Introductionmentioning

confidence: 99%

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Russo

Acierno

Palomba

et al. 2012

Journal of Nanotechnology

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“…Yamamoto Vinyter Co. and Tazawa et al developed the 500 kHz inductive heating system TY-1 with four rolls of water-cooled hollow coils [38]. In 1996, Dai-Ichi High Frequency Co. and Kobayashi et al developed a 118 kHz solenoid type applicator with a horizontal coil (inner diameter, 7 cm; length, 7 cm) for MNHT [17].…”

Section: Magnetic Field Applicators For Mnhtmentioning

confidence: 98%

Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses

Kobayashi

Ito

Honda

2016

Hyperthermic Oncology From Bench to Bedside

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Magnetic nanoparticle-mediated hyperthermia (MNHT) can heat tumor tissue to the desired temperature without damaging surrounding normal tissue. The MNHT system consists of targeting tumor with functional magnetic nanoparticles (MNPs) and then applying an external alternating magnetic field (AMF) to generate heat in the MNPs. Temperature in the tumor tissue is increased to above 43 C, which causes necrosis of cancer cells but does not damage surrounding normal tissue. Among available MNPs, magnetite has been extensively studied. Recent years have seen remarkable advances in MNHT; both functional MNPs and AMF generators have been developed. By applying MNHT, heat shock proteins (HSPs) are highly expressed within and around tumor tissue, which causes intriguing biological responses such as tumor-specific immune response. These results suggest that MNHT is able to kill not only tumors exposed to heat treatment, but also unheated metastatic tumors at distant sites. Currently, some researchers have started clinical trials, suggesting that the time has come for clinical applications.

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“…Induction heating of magnetic oxide particles (by eddy current) is insignificant due to low electric conductivity [366]. Acceptability of magnetic nanoparticles coated with dextran for hyperthermia of mouth cavity [367] is tested in combination with genetic therapy and hyperthermia with usage of cation liposomes, i.e. liposomes filled with magnetic nanoparticles [368].…”

Section: Biomedical Application Of Hybrid Nanocompositesmentioning

confidence: 99%

Bionanocomposites Assembled by “From Bottom to Top” Method

Pomogailo

Джардималиева

2014

Nanostructured Materials Preparation via Condensation Ways

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Particles, which take part in different biological processes, have a special place in nanometer composites. Rich and variable biochemistry of proteins displays key importance of a nanometer phenomenon for a working mechanism of living organisms [1,2], and this provides a wide range of possibilities for development of new types of hybrid nanomaterials with constructible structures, functions and shapes [3][4][5].Integration of nanoparticles and biomolecules, each having unique properties, on the one hand, and being in the same nanometer scale (enzymes, antigens, and antibodies of typical sizes 2-20 nm like nanoparticles), on the other hand, as of two structurally compatible classes of materials, gives resultant new hybrid nanomaterials with synergetic properties and functions (Fig. 7.1).Interaction of nanoparticles with biopolymers (proteins, nucleic acids, polysaccharides) plays very important role in enzyme catalysis, biosorption, biohydrometallurgy, geobiotechnology, etc.). There is a great interest to nanomaterials, which can be used in biomedical and pharmaceutical applications due to their biocompatibility and biodegradation. At the same time bionanocomposites should meet some demands to plasticity of a matrix, they should have improved barrier, antimicrobial properties, ability to controlled release of bioactive substances such as antimicrobial agents, antioxidants, drugs, calcium compounds in biologically available form and their mixtures, etc. Biopolymers, such as natural and synthetic proteins, obtained by chemical methods or by genetic modification of microorganisms or plants, nucleic acids (including synthetic ones), biodegraded complex polyethers, such as polylactic acid, and its derivatives, oligo-hydroxyalkanoate, most often, polyhydroxybutyrate, their copolymers, biomedical materials, such as hydroxyapatites, are used. There is an interesting group of materials for this purpose including synthetic and natural (vegetable and animal) polysaccharides, such as cellulose and its derivatives, alginates, dextranes, acacia gum, chitosan, and any of its natural and synthetic derivatives, especially chitosan acetate, and proteins obtained from raw animal materials, as well as proteins from maize (especially zein) or soya, gluten derivatives, gelatin, casein, etc. Relatively widely used in

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Antitumor effect of new local hyperthermia using dextran magnetite complex in hamster tongue carcinoma

Abstract: These results strongly suggest the usefulness of this local hyperthermic system in the oral region that is accessible to this treatment.

Cited by 43 publications

References 12 publications

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Ultrafine Magnetite Nanopowder: Synthesis, Characterization, and Preliminary Use as Filler of Polymethylmethacrylate Nanocomposites

Magnetic Nanoparticle-Mediated Hyperthermia and Induction of Anti-Tumor Immune Responses

Bionanocomposites Assembled by “From Bottom to Top” Method

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