Antitumor effect of RBS (rice bran saccharide) on ENNG-induced carcinogenesis

Takeshita, Masaaki; Nakamura, Seiji; Makita, Fujio; Ohwada, Susumu; Miyamoto, Yukio; Morishita, Yasuo

doi:10.1007/bf02171758

Cited by 30 publications

(13 citation statements)

References 14 publications

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“…The control mechanisms of the immune system responsible for anticancer activity, combating infections, complement activation, macrophage activation, etc., are responsive to active components of polysaccharides. Reports showing that hemicellulose present in the cell wall of rice bran enhances anticancer immune function 6,7 have prompted active research into the development of rice branderived polysaccharides as new BRMs. However, in most cases, the immune-enhancing polysaccharides contained in rice bran are present as part of a complex with dietary fiber.…”

Section: Introductionmentioning

confidence: 99%

A Polysaccharide Extracted from Rice Bran Fermented withLentinus edodesEnhances Natural Killer Cell Activity and Exhibits Anticancer Effects

Kim

Yang

et al. 2007

Journal of Medicinal Food

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The objective of this study was to investigate the activation of natural killer (NK) cells and anticancer effects of exo-biopolymer from rice bran cultured with Lentinus edodes [rice bran exo-biopolymer (RBEP)]. Oral administration of RBEP induced the activation of NK cells in a dose-dependent manner. RBEP also prolonged the life spans of mice transplanted with Sarcoma-180 cells and inhibited growing Sarcoma-180 cells in intraperitoneum. Solid tumor growth was also suppressed by oral administration of RBEP in C57/Bl6 mice transplanted with B16/Bl6 melanoma. Intraperitoneal injection of RBEP was more effective than oral administration at the same dosage in mice with transplanted tumor cells. According to this result, when RBEP directly contacts immune cells, the anticancer activity is higher than by indirectly inducing an immune response through oral administration. Therefore, we suggest that the administration of RBEP may be effective for preventing and/or treating cancer through NK cell activation. However, further studies are needed to elucidate the possible mechanisms of the anticancer activity and to investigate the other beneficial effects of RBEP for the development of a new biological response modifier.

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Section: Introductionmentioning

confidence: 99%

A Polysaccharide Extracted from Rice Bran Fermented withLentinus edodesEnhances Natural Killer Cell Activity and Exhibits Anticancer Effects

Kim

Yang

et al. 2007

Journal of Medicinal Food

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“…Due to the abundance of some functional compounds, rice bran has drawn the attention of chemists and pharmacologists recently (Azizah and Yu, 2000;Gurpreet and Sogi, 2007;Juan et al, 2006). Among the functional compounds, many biological active polysaccharides extracted from rice bran appeared to elicit excellent physiological properties in maintaining health and preventing diseases such as anti-tumor (Takeshita et al, 1992), enhancing the immune function (Tzianabos, 2000) and increasing the peripheral blood lymphocytes (Takenaka and Itoyama, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of Supplementing Balady Bread With Rice Bran on the High Blood Glucose and Cholesterol Levels

MOBARAK

El-Shazly

Barakat

2010

Journal of Food and Dairy Sciences

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There is an increasing interest with rice bran due to its natural phytochemicals content such as phenolic acids and Vit E which have been reported as strong antioxidants. The purpose of this study was to produce and study the effect of supplementing Balady bread with rice bran on blood glucose and cholesterol levels in diabetic rats. Chemical composition shows that rice bran is good source of protein, minerals, dietary fiber and antioxidants such as phenolic acids and vitamin E. Balady bread was supplemented with 5%, 10%, 15% and 20% of rice bran. Supplementation of Balady bread with rice bran up to 15% increased dietary fibers, phenolic acids and vitamin E content of the bread without negative effects on sensory properties of produced bread. Balady bread Supplemented with 15% and 20% rice bran recorded the highest treating effect on serum glucose and cholesterol levels in diabetic rats. It reduced glucose and cholesterol levels by 40%and 18.4%, respectively, comparing with diabetic rats group (control +ve). The results ascertain the possibility of producing Balady bread supplemented with rice bran as a functional food with high nutritive values and technological qualities for diabetes and hypercholesterolemic people.

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“…Rice bran saccharide (RBS), a polysaccharide component contained in rice bran, exhibits anti-tumor capabilities [ 4 ]. In a study on tumor prevention and suppression of tumor growth in rats, RBS was found to suppress carcinogenesis and to prolong survival rate [ 9 ]. We have not seen any published literature regarding the fractionation of the bran layer to examine RBS concentration.…”

Section: Introductionmentioning

confidence: 99%

“…We have not seen any published literature regarding the fractionation of the bran layer to examine RBS concentration. If RBS can be extracted successfully, rice bran could be a source for a high-value pharmaceutical product [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide

et al. 2007

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Value-added processing with respect to rice milling has traditionally treated the rice bran layer as a homogenous material that contains significant concentrations of high-value components of interest for pharmaceutical and nutraceutical applications. Investigators have shown that high-value components in the rice bran layer vary from differences in kernel-thickness, bran fraction, rice variety, and environmental conditions during the growing season. The objectives of this study were to quantify the amount of rice bran removed at pre-selected milling times and to correlate the amount of rice bran removed at each milling time with the concentration of vitamin E, gamma-oryzanol, rice bran saccharide, and protein obtained. The ultimate goal of this research is to show that rice bran fractionation is a useful method to obtain targeted, nutrient-rich bran samples for value-added processing. Two long grain rice cultivars, Cheniere and Cypress, were milled at discrete times between 3 and 40 seconds using a McGill mill to obtain bran samples for analysis. Results showed that the highest oryzanol and protein concentrations were found in the outer portion of the rice bran layer, while the highest rice bran saccharide concentration was found in the inner portion of the bran layer. Vitamin E concentration showed no significant difference across the bran layer within a variety, though the highest magnitude of concentration occurs within the first 10 seconds of milling for both varieties. To extract the higher concentration of oryzanol and protein only the outer portion of the bran layer requires processing, while to extract the higher concentration of rice bran saccharide, only the inner portion of the bran layer requires processing. Rice bran fractionation allows for the selective use of portions of the bran layer and is advantageous for two reasons: (1) bran fractions contain higher concentrations of components of interest with respect to the overall bran layer average, and (2) less bran needs to be processed to obtain components of interest.

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Antitumor effect of RBS (rice bran saccharide) on ENNG-induced carcinogenesis

Cited by 30 publications

References 14 publications

A Polysaccharide Extracted from Rice Bran Fermented withLentinus edodesEnhances Natural Killer Cell Activity and Exhibits Anticancer Effects

A Polysaccharide Extracted from Rice Bran Fermented withLentinus edodesEnhances Natural Killer Cell Activity and Exhibits Anticancer Effects

Effect of Supplementing Balady Bread With Rice Bran on the High Blood Glucose and Cholesterol Levels

Fractionation of the rice bran layer and quantification of vitamin E, oryzanol, protein, and rice bran saccharide

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