Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways

Abstract

Abstract. Chondrosarcoma is one of the most common types of primary bone cancer that develops in cartilage cells. Resveratrol (Res), a natural polyphenol compound isolated from various fruits, has a suppressive effect on various human malignancies. It has been shown that Res inhibits matrix metalloproteinase (MMP)-induced differentiation in chondrosarcoma cells. However, the effects of Res on cell proliferation, apoptosis and invasion of chondrosarcoma cells, as well as the underlying mechanisms, remain largely unknown. To the best of our knowledge, the present study showed for the first time that Res inhibited proliferation and induced apoptosis in chondrosarcoma cells in a dose-dependent manner. Furthermore, it was shown that Res also suppressed chondrosarcoma cell invasion in a dose-dependent manner, probably via the inhibition of MMP2 and MMP9 protein expression. Molecular mechanism investigations revealed that Res could inhibit the activity of phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase signaling pathways, which has been demonstrated to be important in the regulation of proliferation, apoptosis and invasion in various cancer cell types. In conclusion, this study suggests that Res may serve as a promising agent for the treatment of chondrosarcoma.

Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways

“…Lin et al (36) recenly proved that resveratrol was able to inhibit glucose-induced migration of vascular smooth muscle cells mediated by focal adhesion kinase via AKT and ERK signaling pathways. Dai et al (37) indicated that resveratrol suppressed chondrosarcoma cell invasion via AKT and p38 MAPK pathways. Here, we found that resveratrol was also able to inhibit hyperglycemia-induced invasion and migration abilities of pancreatic cancer cells.…”

Reversing Epigenetic Alterations Caused by Alcohol: A Promising Therapeutic Direction for Alcoholic Liver Disease

“…Additionally, resveratrol could down‐regulate miR‐21, which is up‐regulated in ALD and related to cell apoptosis (Francis et al., ), remodeling, and liver regeneration (Dippold et al., ) in human SW480 colon cancer cells. Therapeutic effect of resveratrol on other diseases through epigenetic regulation has also been reported (Dai et al., ; Zhang et al., ). Therefore, resveratrol could possibly reverse or cure ALD through epigenetic regulation, which needs further investigation.…”

Unraveling the Anticancer Effect of Curcumin and Resveratrol

“…By western blot analysis, it was demonstrated that the PI3K, Akt and AMPK levels decreased significantly in a concentration of resveratrol enough to cause apoptosis. This result suggest that the inhibition of PI3K pathway by resveratrol may be a molecular mechanism to suppress cancer cell proliferation [335]. …”