2020
DOI: 10.3892/ijmm.2020.4494
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Antitumor effects and mechanisms of pyropheophorbide‑α methyl ester‑mediated photodynamic therapy on�the human osteosarcoma cell line MG‑63

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Cited by 9 publications
(22 citation statements)
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“…During the PDT-mediated reticulophagy, ATF4 or CHOP upregulates the expression of TRIB3 or autophagy-relevant proteins (ATG5, ATG12, and Beclin 1), as well as downregulates the expression of BCL-2 ( 62 , 135 , 136 ). The PDT-mediated autophagy can be chemically regulated by some drugs as depicted in Figure 3 , such as rapamycin, BEZ235, LY-294000, Compound C, 3-MA, and wortmannin ( 56 , 60 , 100 , 103 , 104 , 144 147 ).…”
Section: Pdt-mediated Autophagy Regulation In Tumor Cellsmentioning
confidence: 99%
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“…During the PDT-mediated reticulophagy, ATF4 or CHOP upregulates the expression of TRIB3 or autophagy-relevant proteins (ATG5, ATG12, and Beclin 1), as well as downregulates the expression of BCL-2 ( 62 , 135 , 136 ). The PDT-mediated autophagy can be chemically regulated by some drugs as depicted in Figure 3 , such as rapamycin, BEZ235, LY-294000, Compound C, 3-MA, and wortmannin ( 56 , 60 , 100 , 103 , 104 , 144 147 ).…”
Section: Pdt-mediated Autophagy Regulation In Tumor Cellsmentioning
confidence: 99%
“…Some reports have shown that depending on the stress level, the autophagic apparatus might intrinsically contribute to other cell death programs, like apoptosis or necroptosis ( 35 , 56 , 59 , 62 , 104 , 128 , 141 , 144 , 145 , 147 , 155 , 166 170 ), see Table 2 . In spite of not inducing cell death per si , the RCD routine autophagy-mediated cell death (AMCD) may be significantly rescued by chemical autophagic inhibition (e.g.…”
Section: Pdt-mediated Autophagy Regulation In Tumor Cellsmentioning
confidence: 99%
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“…However, excessive or prolonged erS can induce cell apoptosis (24)(25)(26), and it has been reported that melatonin can initiate erS-induced apoptosis in human hepatoma cells (27). in addition, excessive erS caused by a high concentration of melatonin is a direct factor for inducing apoptosis (28). it is also speculated that these effects be due to the high concentration of melatonin caused by ca 2+ overload and the induction of osteoblastic erS, but this is yet to be elucidated.…”
Section: Introductionmentioning
confidence: 99%