Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

Notarbartolo, Monica; Poma, Paola; Perri, Daniela; Dusonchet, Luisa; Cervello, Melchiorre; D’Alessandro, Natale

doi:10.1016/j.canlet.2004.10.051

Cited by 290 publications

(178 citation statements)

References 31 publications

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“…Other studies have also reported a synergistic interaction between different treatment strategies (Liu et al, 2001;Kuhar et al, 2007;Kumi-Diaka et al, 2010;Wang et al, 2011). Other studies of concurrent curcumin and chemotherapeutic drugs such as cisplatin, doxorubicin, and taxol showed that curcumin enhances the antitumor activities of the latter in various cancer cells (Chan et al, 2003;Notarbartolo et al, 2005). SFN when used in combination with arsenic trioxide and doxorubicin augmented their growth inhibitory properties (Fimognari et al, 2007;Doudican et al, 2012).…”

Section: Discussionmentioning

confidence: 97%

“…In order to avoid the complications associated with standard cancer treatments for instance chemotherapy, combinational treatment strategies involving chemopreventive agents have been proposed for achieving a therapeutic synergy between individual drugs, while minimizing systemic toxicity caused by these therapies (Notarbartolo, 2005;Kumi-Diaka et al, 2010;Doudican et al, 2012). The present study was undertaken to analyze the chemopreventive activity of SFN alone and its interaction with a chemotherapeutic drug, gemcitabine on human breast cell line (MCF-7).…”

Section: Introductionmentioning

confidence: 99%

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Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

Hussain¹,

Mohsin²,

Prabhu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Phytochemicals are among the natural chemopreventive agents with most potential for delaying, blocking or reversing the initiation and promotional events of carcinogenesis. They therefore offer cancer treatment strategies to reduce cancer related death. One such promising chemopreventive agent which has attracted considerable attention is sulforaphane (SFN), which exhibits anti-cancer, anti-diabetic, and anti-microbial properties. The present study was undertaken to assess effect of SFN alone and in combination with a chemotherapeutic agent, gemcitabine, on the proliferative potential of MCF-7 cells by cell viability assay and authenticated the results by nuclear morphological examination.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

Hussain¹,

Mohsin²,

Prabhu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…This observation results particularly important on considering that at present there is no antitumoral chemiotherapic drug against anaplastic thyroid cancer (ATC) and survival of patients is less than 1 year. Moreover for resistant cell lines, such as the hepatic cancer HA22T/VGH cell, curcumin was usually administered in combination with other chemiotherapic agents to achieve synergistic antitumor effect (Notarbartolo et al, 2005;Ganta and Amiji, 2009). …”

Section: Cells Viabilitymentioning

confidence: 99%

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Riela

Massaro

Colletti

et al. 2014

International Journal of Pharmaceutics

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109

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“…One way to explain our finding is to consider the role of nuclear factor-kappa B (NF-k B) on up-regulation of IAPs [52]. It is known that TF (NF-kB) is activated in the reprogrammed HRS cells [2].…”

Section: Discussionmentioning

confidence: 89%

Livin Expression by Semi-quantitative Immuno-flourecent Staining in Hodgkin Lymphoma: A Promising Marker or a Leading Role in Pathogenesis?

Pouya¹

2015

J Cytol Histol

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A novel human inhibitor of apoptosis protein family member, termed Livin, was demonstrated in the pathogenesis of different human malignancies, and also it was studied as a potential treatment target in malignancies. However, there is no report on the Livin expression profile in Hodgkin Lymphoma. In this study, we evaluated the Livin expression in 78 paraffin embedded blocks including 39 staged cases of Hodgkin Lymphoma and 39 control subjects (normal and reactive hyperplasia lymph nodes). Tissue Microarray-based Semi-quantitative Immuno-flourecent Staining was applied for protein expression profiling in both infiltrating non-neoplastic cells (morphologically typical Lymphocytes) and neoplastic cells (Hodgkin and Reed-Sternberg) of cases and control samples. Our results demonstrated that the mean ratio of Livin/GAPDH expression was significantly increased between infiltrating background cells in Hodgkin Lymphomas and control cases (0.54596 vs. 0.50827, P<0.001). Also, a significant difference was found in the mean ratio of Livin/GAPDH expression between neoplastic cells and major background cells in the tumor microenvironment (0.59024 vs. 0.54596, p<0.001). Furthermore, this study confirmed a significant increase of Livin expression from early-stage to advanced-stage of Hodgkin Lymphoma (0.52888 vs. 0.580146, P<0.01).These findings suggest that Livin may play a critical role in the pathogenesis of Hodgkin Lymphoma. It also can be a novel prognostic marker and a potential therapeutic target in this type of lymphoma.

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Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expression

Cited by 290 publications

References 31 publications

Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

Sulforaphane Inhibits Growth of Human Breast Cancer Cells and Augments the Therapeutic Index of the Chemotherapeutic Drug, Gemcitabine

Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity

Livin Expression by Semi-quantitative Immuno-flourecent Staining in Hodgkin Lymphoma: A Promising Marker or a Leading Role in Pathogenesis?

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