Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview

Patiño‐Morales, Carlos César; Jaime-Cruz, Ricardo; Sánchez‐Gómez, Concepción; Corona, Juan Carlos; Hernández-Cruz, Estefani Yaquelin; Kalinova-Jelezova, Ivia; Pedraza‐Chaverrí, José; Maldonado, Perla D.; Silva-Islas, Carlos Alfredo; Salazar–García, Marcela

doi:10.3390/antiox11010048

Cited by 19 publications

(15 citation statements)

References 70 publications

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“…Allium stadium is renowned as "garlic" by the general public. You can get it in a range of methods, and it is a well-known and valuable spice [103]. Antioxidant, hypotensive, antimicrobial, antifungal, antitumorigenic, immunomodulatory, anti-inflammatory, hepatoprotective, anthelmintic, anticoagulant, and fibrinolytic characteristics are all present in it [104][105][106][107].…”

Section: Neuroprotective Roles Of Phytochemicalsmentioning

confidence: 99%

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Shohag

Akhter

Islam

et al. 2022

Oxidative Medicine and Cellular Longevity

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Molecules with at least one unpaired electron in their outermost shell are known as free radicals. Free radical molecules are produced either within our bodies or by external sources such as ozone, cigarette smoking, X-rays, industrial chemicals, and air pollution. Disruption of normal cellular homeostasis by redox signaling may result in cardiovascular, neurodegenerative diseases and cancer. Although ROS (reactive oxygen species) are formed in the GI tract, little is known about how they contribute to pathophysiology and disease etiology. When reactive oxygen species and antioxidants are in imbalance in our bodies, they can cause cell structure damage, neurodegenerative diseases, diabetes, hypercholesterolemia, atherosclerosis, cancer, cardiovascular diseases, metabolic disorders, and other obesity-related disorders, as well as protein misfolding, mitochondrial dysfunction, glial cell activation, and subsequent cellular apoptosis. Neuron cells are gradually destroyed in neurodegenerative diseases. The production of inappropriately aggregated proteins is strongly linked to oxidative stress. This review’s goal is to provide as much information as possible about the numerous neurodegenerative illnesses linked to oxidative stress. The possibilities of multimodal and neuroprotective therapy in human illness, using already accessible medications and demonstrating neuroprotective promise in animal models, are highlighted. Neuroprotection and neurolongevity may improve from the use of bioactive substances from medicinal herbs like Allium stadium, Celastrus paniculatus, and Centella asiatica. Many neuroprotective drugs’ possible role has been addressed. Preventing neuroinflammation has been demonstrated in several animal models.

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Section: Neuroprotective Roles Of Phytochemicalsmentioning

confidence: 99%

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Shohag

Akhter

Islam

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…5 2021 have mentioned the use of Allium sativum in treatment of numerous pathologies including cancer. 15 The active constituents of garlic includes organosulfur compounds: alliin, allicin, S-allylcysteine, diallyl sulfide, diallyl disulfide, and diallyl trisulfide; flavonoids; phenolic compounds; vitamins, enzymes, minerals (iron, manganese, magnesium, calcium, selenium) and amino acids. These constituents may potentiate anti-oxidant, anti-microbial, analgesic, antiinflammatory and anti-cancer effects.…”

Section: Acute Oral Toxicity Testmentioning

confidence: 99%

Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects

2022

TJNPR

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The study was aimed at carrying out pre-clinical studies on the poly-herbal formulation having evidence-based anti-oxidant and anti-cancer properties. The study involved the following preclinical studies on the poly herbal drug: behavioral studies were carried out at doses 50 mg and 100 mg/kg respectively using open field and light and dark methods; analgesic activity based on acetic acid induced writhing test was performed at 50 mg and 100 mg/kg doses of the extract; anti-inflammatory activity of the poly-herbal extract was conducted at the following doses: 10, 50, 100, and 150 mg/ml. Acute oral toxicity studies on the herbal extract were carried out at 5, 50, 300, 2000 and 5000 mg/kg doses. The results of pre-clinical studies carried out were comparable to the standards used endorsing the efficacy and safety of the herbal formulation under test. The efficacy and safety results of the activities carried out on the poly-herbal antioxidant and anti-cancer formulation by the researchers under test in this study and that of the already reported pharmacognostic, chemical, cytotoxic, anti-microbial and anti-oxidant results are suggestive of initiation of clinical studies on this supportive anti-oxidant and anti-cancer formulation.

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“…Several studies state that garlic is an effective drug in preventing and treating several diseases, such as atherosclerosis, due to its lipid-lowering effect, mild arterial pressure reduction, and fibrinolytic and platelet anti-aggregation activity. Garlic also contains antioxidant, hypotensive, antimicrobial, antifungal, antitumorigenic, and immunomodulatory properties (Patiño-Morales et al, 2022).…”

Section: Growth Form and Plant Part Usedmentioning

confidence: 99%

Ethnobotanical study of the medicinal plant by local communities in karst area of Pacitan District, East Java, Indonesia

AMMAR

KURNIAWATI²,

ANGGOROWATI³

et al. 2021

Intl J Trop Drylands

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Abstract. Ammar LA, Kurniawati B, Anggorowati D, Cahyaningsih AP, Setyawan AD. 2021. Ethnobotanical study of the medicinal plant used by local communities in karst area of Pacitan District, East Java, Indonesia. Intl J Trop Drylands 5: 84-93. Local people's trust in traditional medicine methods is still high, especially in rural areas. Most of the villagers in Tulakan Sub-district, Pacitan District, East Java, Indonesia, grow their medicinal plants in their yards. However, local people's knowledge of various medicinal plant types is only conveyed orally from parents to children and community practice habits. Information about the using medicinal plants may begin to degrade from time to time. This study aimed to investigate the knowledge of local communities regarding the use of medicinal plants and the plant diversity, especially in the village of karst areas. The research was conducted in Bungur Village and Tulakan Village, Tulakan Sub-district, Pacitan District, East Java, Indonesia. Data collection was carried out using the snowball technique through open interviews and field surveys. A total of 40 respondents with 7 people of young age range 15-40 years and 33 people of old age range 41-75 years. Respondents with the most educational backgrounds are high school graduates. A total of 51 species were found, from 46 genera and 29 families, with 35 diseases being treated. Fever, cough, and external wounds are the most commonly treated diseases. The most widely used medicinal plant is Zingiber officinale Roscoe to warm the body, prevent fever, and increase immunity. During the COVID-19 pandemic, the villagers orally consumed ginger for post-COVID-19 positive recovery and maintained health. The most used plant parts are leaves and rhizomes by decoction and consumption orally. Based on the research results, it is known that the knowledge of the local communities and the use of medicinal plants is still quite good among the older and younger people with various types of plants.

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Antitumor Effects of Natural Compounds Derived from Allium sativum on Neuroblastoma: An Overview

Cited by 19 publications

References 70 publications

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Behavioral, Analgesic, Anti-Inflammatory and Acute Oral Toxicity Studies on Poly-Herbal Formulation with Anti-Oxidant and Anti-Cancer Effects

Ethnobotanical study of the medicinal plant by local communities in karst area of Pacitan District, East Java, Indonesia

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