Antitumor impact of iron oxide nanoparticles in Ehrlich carcinoma-bearing mice

Abstract

Magnetic nanoparticles are promising approaches for cancer treatment. Iron oxide nanoparticles have been pre-formed by the co-precipitation method to investigate their antitumor activity on Ehrlich carcinoma in mice. The nanoparticles have been studied by UV spectrophotometer, transmission electron microscopy, dynamic light scattering, and zeta potential measurement. To determine the therapeutic impact of Iron oxide nanoparticles in tumorbearing mice, in vivo experiments were carried out. Fourier Transform Infra-red (FTIR) spectroscopy and DNA comet assay were used to estimate the toxicity of nanoparticles of iron oxide. The tissue was analyzed using FTIR spectral parameters such as the area beneath the peak, peak position, and peak intensity. The results showed that iron oxide nanoparticles significantly led to antitumor activity against Ehrlich carcinoma. There was a low shift in position and intensity at the amide I band (1650 cm −1 ) in tissues of mice treated with iron oxide nanoparticles compared to the control group. Comet examination showed a decrease across all the parameters of the assay (tail moment, tail DNA percentage, and tail length) in the tumor + iron nanoparticles group, having values lower than the tumor group. According to the presented results, Iron oxide nanoparticles have exhibited therapeutic efficacy against cancer.

Chitosan and Aloe Vera decorated nanoparticulate system loaded with Minoxidil as a suggested topical formulation for alopecia therapy

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GANE can Improve Lung Fibrosis by Reducing Inflammation via Promoting p38MAPK/TGF-β1/NF-κB Signaling Pathway Downregulation

“…As a continuation of our interesting research in evaluation of therapeutic potential drugs of medical importance, − we report herein, a facile route to prepare a new nano-formula for gallic acid and evaluate its preventive efficacy against LPS-induced lung fibrosis in rats.…”

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

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“… 6 , 7 Nanoparticles can be selectively used to target the delivery of therapeutic drugs 8 and decrease drug resistance by cancer cells. 9 Niosomes are distinctive drug nanocarriers developed by non-ionic surfactants and cholesterol self-association in an aqueous solution. 10 They can encapsulate hydrophilic and hydrophobic drugs with adequate efficiency.…”