Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

Yan, Chaobiao; Yu, Lei; Liu, Hanqing; Chen, Diyu; Wu, Jian

doi:10.1016/j.bbcan.2023.188905

Cited by 9 publications

(3 citation statements)

References 214 publications

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“…These results suggest that CBD may be an effective treatment against ICH-induced OS. However, several recent reports have also indicated that CBD can promote ROS production in cancer cells to induce cell apoptosis ( Yan et al, 2023 ). The conflicting results may be partly related to the type of cells examined.…”

Section: Discussionmentioning

confidence: 99%

Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

Yan,

Zhang,

et al. 2023

Front. Pharmacol.

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Intracerebral hemorrhage (ICH) is a subtype of stroke with a high mortality rate. Oxidative stress cascades play an important role in brain injury after ICH. Cannabidiol, a major non-psychotropic phytocannabinoids, has drawn increasing interest in recent years as a potential therapeutic intervention for various neuropsychiatric disorders. Here we provide a comprehensive review of the potential therapeutic effects of cannabidiol in countering oxidative stress resulting from ICH. The review elaborates on the various sources of oxidative stress post-ICH, including mitochondrial dysfunction, excitotoxicity, iron toxicity, inflammation, and also highlights cannabidiol’s ability to inhibit ROS/RNS generation from these sources. The article also delves into cannabidiol’s role in promoting ROS/RNS scavenging through the Nrf2/ARE pathway, detailing both extranuclear and intranuclear regulatory mechanisms. Overall, the review underscores cannabidiol’s promising antioxidant effects in the context of ICH and suggests its potential as a therapeutic option.

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Section: Discussionmentioning

confidence: 99%

Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

Yan,

Zhang,

et al. 2023

Front. Pharmacol.

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“…Moreover, in PANC-1 and MIAPaCa-2 cells, CBD also induced apoptosis and Caspase-3 activation [19]. Lastly, many studies demonstrated that cannabinoids could increase the efficacy of chemotherapeutic drugs, reducing tumor growth and overcoming drugs resistance [11]. Herein, the combination of CBG with GEM or PTX increased the cytotoxicity compared to the administration of the drug alone, also showing a synergistic effect for some combinations.…”

Section: Discussionmentioning

confidence: 91%

“…Phytocannabinoids, such as ∆9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD), compounds derived from Cannabis sativa L., as well as medical cannabis, were evidenced to exert antitumoral activity when used in combination with other therapies in glioblastoma, as reported in one clinical trial and in one case report [9,10]. Moreover, many in vitro and in vivo preclinical studies evidenced that phytocannabinoids show antitumoral effects in different human cancers, and synergistic effects are observed with approved chemotherapeutic drugs, as recently reviewed in [11].…”

Section: Introductionmentioning

confidence: 96%

Cannabigerol Induces Autophagic Cell Death by Inhibiting EGFR-RAS Pathways in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Zeppa,

Aguzzi,

Morelli

et al. 2024

IJMS

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Pancreatic ductal adenocarcinoma (PDAC) is the most frequent infiltrating type of pancreatic cancer. The poor prognosis associated with this cancer is due to the absence of specific biomarkers, aggressiveness, and treatment resistance. PDAC is a deadly malignancy bearing distinct genetic alterations, the most common being those that result in cancer-causing versions of the KRAS gene. Cannabigerol (CBG) is a non-psychomimetic cannabinoid with anti-inflammatory properties. Regarding the anticancer effect of CBG, up to now, there is only limited evidence in human cancers. To fill this gap, we investigated the effects of CBG on the PDAC cell lines, PANC-1 and MIAPaCa-2. The effect of CBG activity on cell viability, cell death, and EGFR-RAS-associated signaling was investigated. Moreover, the potential synergistic effect of CBG in combination with gemcitabine (GEM) and paclitaxel (PTX) was investigated. MTT was applied to investigate the effect of CBG on PDAC cell line viabilities. Annexin-V and Acridine orange staining, followed by cytofluorimetric analysis and Western blotting, were used to evaluate CBG’s effect on cell death. The modulation of EGFR-RAS-associated pathways was determined by Western blot analysis and a Milliplex multiplex assay. Moreover, by employing the MTT data and SynergyFinder Plus software analysis, the effect of the combination of CBG and chemotherapeutic drugs was determined.

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Cannabidiol effects in stem cells: A systematic review

Mesas,

Moreno,

Doello

et al. 2024

BioFactors

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Stem cells play a critical role in human tissue regeneration and repair. In addition, cancer stem cells (CSCs), subpopulations of cancer cells sharing similar characteristics as normal stem cells, are responsible for tumor metastasis and resistance to chemo‐ and radiotherapy and to tumor relapse. Interestingly, all stem cells have cannabinoid receptors, such as cannabidiol (CBD), that perform biological functions. The aim of this systematic review was to analyze the effect of CBD on both somatic stem cells (SSCs) and CSCs. Of the 276 articles analyzed, 38 were selected according to the inclusion and exclusion criteria. A total of 27 studied the effect of CBD on SSCs, finding that 44% focused on CBD differentiation effect and 56% on its protective activity. On the other hand, 11 articles looked at the effect of CBD on CSCs, including glioblastoma (64%), lung cancer (27%), and breast cancer (only one article). Our results showed that CBD exerted a differentiating and protective effect on SCCs. In addition, this molecule demonstrated an antiproliferative effect on some CSCs, although most of the analyses were performed in vitro. Therefore, although in vivo studies should be necessary to justify its clinical use, CBD and its receptors could be a specific target to act on both SSCs and CSCs.

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Antitumor mechanism of cannabidiol hidden behind cancer hallmarks

Cited by 9 publications

References 214 publications

Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

Anti-oxidant effects of cannabidiol relevant to intracerebral hemorrhage

Cannabigerol Induces Autophagic Cell Death by Inhibiting EGFR-RAS Pathways in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Cannabidiol effects in stem cells: A systematic review

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