Antitumor Natural Products

Mitscher, Lester A.; Dutta, Apurba

doi:10.1002/0471266949.bmc076

Cited by 2 publications

(1 citation statement)

References 256 publications

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“…Doxorubicin, a hydroxylated similar of daunorubicin, is a natural anthracycline derivative. Doxorubicin is used for the treatment of many diseases such as neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, acute lymphoblastic leukaemia, soft tissue and bone sarcomas, transitional cell bladder carcinoma, breast carcinoma, bronchogenic carcinoma, ovarian carcinoma, gastric carcinoma, and thyroid carcinoma [9][10][11].…”

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confidence: 99%

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Bakırhan¹,

Akmeşe²,

Yazicigil³

et al. 2019

jrp

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The degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The degradation pathway determined by high-performance liquid chromatography (HPLC). Daunorubicin, doxorubicin and vincristine completely disintegrated in the basic medium. It has been determined that these drugs are resistant to heat. Daunorubicin and doxorubicin are resistant to UV light. However, vincristine is not very stable such as the other two compounds against UV light. The kinetic and thermodynamic parameters of daunorubicin, doxorubicin and vincristine were investigated in neutral media with different temperatures by electrochemical technique. Enthalpy, entropy and Gibbs free energy parameters were investigated in pH 7.4 phosphate buffer (PB) solution due to stability of these drugs at this pH. The studied chemotherapeutic agents showed endothermic process on glassy carbon-based electrode surface. Daunorubicin, doxorubicin and vincristine showed strongly adsorption process in room temperature. However, it showed diffusion property from electrode to solution with increasing the temperature values.

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Section: Introductionmentioning

confidence: 99%

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Bakırhan¹,

Akmeşe²,

Yazicigil³

et al. 2019

jrp

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Identification of Four New Degradation Products of Epirubicin Through Forced Degradation, LC–UV, MSⁿand LC–MS–TOF Studies

2015

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Epirubicin (EPI) was subjected to International Conference on Harmonization recommended forced degradation under the conditions of hydrolysis, oxidation, dry heat and photolysis to characterize its possible impurities and/or degradation products. The drug was found highly unstable to alkaline hydrolysis even at room temperature, unstable to acid hydrolysis at 80°C and to oxidation at room temperature. The hydrolytic and oxidative degradation products were resolved on an Agilent RP8 (150 mm × 4.6 mm; 5 µm) column with isocratic elution using mobile phase composed of ammonium formate (10 mM, pH 3.0), acetonitrile and methanol. The drug degraded to four oxidative products (O-I, O-II, O-III and O-IV) and to one acid hydrolyzed product (A-I). Purity of each peak in liquid chromatography-ultraviolet (LC-UV) chromatogram was ascertained through photodiode array (LC-PDA) analysis. The products were characterized through electrospray ionization-mass spectrometry (+ESI-MS(n)) studies on EPI and liquid chromatography-time of flight mass spectrometry (LC-MS-TOF) studies on degraded drug solutions. The products, O-I-O-IV, were characterized as 2-hydroxy-8-desacetylepirubicin-8-hydroperoxide, 4-hydroxy-8-desacetylepirubicin-8-hydroperoxide, 8-desacetylepirubicin-8-hydroperoxide and 8-desacetylepirubicin, respectively, and product A-I was characterized as deglucosaminylepirubicin. While A-I was found to be a pharmacopoeial impurity, all oxidative products were found to be new degradation impurities. The mechanisms and pathways of degradation of EPI were discussed and outlined.

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Antitumor Natural Products

Cited by 2 publications

References 256 publications

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Identification of Four New Degradation Products of Epirubicin Through Forced Degradation, LC–UV, MSⁿand LC–MS–TOF Studies

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Antitumor Natural Products

Cited by 2 publications

References 256 publications

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine

Identification of Four New Degradation Products of Epirubicin Through Forced Degradation, LC–UV, MSnand LC–MS–TOF Studies

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Identification of Four New Degradation Products of Epirubicin Through Forced Degradation, LC–UV, MSⁿand LC–MS–TOF Studies