Antitumor Peptides from Marine Organisms

Zheng, Lanhong; Wang, Yuejun; Sheng, Jun; Wang, Fang; Zheng, Yuanyuan; Lin, Xiukun; Sun, Mi-Shu

doi:10.3390/md9101840

Cited by 128 publications

(114 citation statements)

References 128 publications

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“…Moto purines and congeners are protein phosphatase inhibitors [27]. The complex polyketide swinholide A and bistheonellide A are biologically active metabolites that show nanomolar potent against tumor cells [6,7]. There are actin disrupting compounds derived from lithistida like kabiramide, sphinxolide and reidispongiolide, callipeltoside but these are not meant for commercial purposes [11,12].…”

Section: Commercially Available Biochemical Probes From Lithistid Spomentioning

confidence: 99%

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Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Abirla

2018

Asian J Pharm Clin Res

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Lithistid sponges have an important source of complex natural compounds with biological activities. The lithistid sponges are of interest to biomedical science because of the great variety of pharmaceutically relevant biological activities of their chemical extracts and are considered as economically important. The compounds identified in these sponges have therapeutic potential and have been frequently hypothesized to contain compounds of bacterial origin. The peptides identified from these lithistid sponges are found to be the sources of antifungal activity. The active agents of these sponges also have cytotoxic and immunosuppressive activities. Many of the cyclic peptides of lithistid represent the anti-HIV activity. The different structure and biological activities of the compounds derived from these sponges have more chemical aspects too.

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Section: Commercially Available Biochemical Probes From Lithistid Spomentioning

confidence: 99%

“…Consequently, advancements in sampling techniques, structure determination strategies as well as target identification methods represent crucial steps in marine drug discovery [7,8].…”

Section: Introductionmentioning

confidence: 99%

Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Abirla

2018

Asian J Pharm Clin Res

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“…Peptides can be used as drugs, hormones, or immunization agents (vaccines) (Sah et al 2015). The biological effects include inhibition of tumor vasculature growth (angiogenesis), alterations in protein-protein interaction, changes in gene expression, and apoptosis, among others (Rosca et al 2011;Walensky et al 2004;Zheng et al 2011).…”

Section: Peptide-based Strategies For Cancermentioning

confidence: 99%

Anticancer Peptides: Prospective Innovation in Cancer Therapy

Gaspar

Castanho

2016

Host Defense Peptides and Their Potential as Therapeutic Agents

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Current cancer treatments require improvements in selectivity and efficacy. Surgery, radiation, and chemotherapy approaches result in patient's suffering over time due to the development of severe side-effects that simultaneously condition adherence to therapy. Biologically active peptides, in particular antimicrobial peptides (AMPs), are versatile molecules in terms of biological activities. The cytotoxic activities of several AMPs turn this group of molecules into an amazing pool of new templates for anticancer drug development. However, several unmet challenges limit application of peptides in cancer therapy. The mechanism(s) of action of the peptides need better description and understanding, and innovative targets have to be discovered and explored, facilitating drug design and development. In this chapter, we explore the natural occurring AMPs as potential new anticancer peptides (ACPs) for cancer prevention and treatment. Their modes of action, selectivity to tumor compared to normal cells, preferential targets, and applications, but also their weaknesses, are described and discussed.

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“…The complex interactions between biological and chemical factors stimulated marine organisms to produce different biological active compounds (Zheng et al, 2011). Associated microorganisms utilized their host's nutrients and in return protected themselves to avoid damage by secreting bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of <i>Staphylococcus epidermidis</i> S14 Screening Extracellular Antimicrobial Metabolites

Zhang¹,

Jiang²,

Jiang³

et al. 2016

American Journal of Biochemistry and Biotechnology

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Total 24 isolates with antimicrobial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus and Shigella castellani, out of 259 strains, were isolated from the internal of seven marine fishes. The extracellular metabolites of strain S14, isolated from the internal of shark, showed stronger inhibition against the four tested bacteria, including G-and G+ bacteria. Based on the 16S rDNA the sequencing analysis, the strain S14 belonged to a member of Staphylococcus epidermidis with 99% DNA similarity and named to Staphylococcus epidermidis S14. The Staphylococcus epidermidis S14 secreted rarely antibacterial substance in the stabilization period and the antibacterial active substances might be the secondary metabolites. The antibacterial metabolites were not hydrolyzed by pepsin, trypsin and lysozyme. The antibacterial metabolites were stable for 30 min to high temperature treatment at 100°C and had higher antibacterial activity at neutral pH.

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Antitumor Peptides from Marine Organisms

Cited by 128 publications

References 128 publications

Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Lithistid Sponges Derived Compounds and Their Importance in Biological Research - A Review

Anticancer Peptides: Prospective Innovation in Cancer Therapy

Isolation and Identification of <i>Staphylococcus epidermidis</i> S14 Screening Extracellular Antimicrobial Metabolites

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