Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities

Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis

“…There are recent reports for anti-cancerous activities of various polysaccharides form different sources (Meng et al, 2016). Recently, there is a shift from microbial polysaccharides to plant polysaccharides because latter are mainly non-toxic and may not cause side effects (Schepetkin and Quinn, 2006).…”

Polysaccharides fromTrichosanthes Fructusvia Ultrasound-Assisted Enzymatic Extraction Using Response Surface Methodology

“…So, the natural polysaccharides need structure modification to improve the efficacy in future work, as the obvious flaws of these polysaccharides, such as the structural heterogeneity, relatively lower active group, and poor solubility [33]. The antitumor activities of the polysaccharides may result from their abilities to modulate signaling pathways via regulating host's immune system or direct cytotoxic effects, such as inducing apoptosis of cancer cell, the effects of antiangiogenesis, and cell cycle arrest [34]. The polysaccharides are also capable of generating free radicals and oxidative stress, which are related to the antitumor activities of the polysaccharides [34, 35].…”

“…The antitumor activities of the polysaccharides may result from their abilities to modulate signaling pathways via regulating host's immune system or direct cytotoxic effects, such as inducing apoptosis of cancer cell, the effects of antiangiogenesis, and cell cycle arrest [34]. The polysaccharides are also capable of generating free radicals and oxidative stress, which are related to the antitumor activities of the polysaccharides [34, 35]. Therefore, polysaccharides from T. Fructus can be explored as a kind of natural medicine for potential antitumor treatment.…”

Cytotoxic effect of a mannogalactoglucan extracted from Agaricus bisporus on HepG2 cells

“…Most mushroom polysaccharides seem to exert their antitumor activity through the activation of multiple pathways of the host immune response and are therefore considered immune response modifiers (Borchers et al, 2004;Ren et al, 2012;Wang et al, 1995). The antitumor effects of some polysaccharides con be in part explained to their cytotoxic effect inducing apoptosis of cancer cells (Hattori et al, 2004;Hirahara et al, 2012;Hsu et al, 2005;Meng et al, 2016). As one example, in a previous study, we demonstrated that a linear (1→6) β-D-glucan from A. bisporus decreased the viability of human hepatocarcinoma cells (HepG2) and promoted morphological and biochemical modifications indicative of apoptosis.…”