Antitumor potential of carrageenans from marine red algae

Khotimchenko, Maksim; Tiasto, Vladlena; Kalitnik, A. A.; Begun, Mariya A.; Khotimchenko, Rodion; Leonteva, Ekaterina; Bryukhovetskiy, Igor; Khotimchenko, Yuri

doi:10.1016/j.carbpol.2020.116568

Cited by 107 publications

(60 citation statements)

References 136 publications

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“…Furthermore, chemically modified derivatives obtained by sulfation, acetylation, and phosphorylation significantly increase anti-tumor activity of κ-oligo carrageenans in mice tumor xenografts S180 model. Anti-tumor effects of sulfated and phosphorylated derivatives of κ-oligo carrageenans are similar to the effects of ftorafur, which is a potent chemotherapeutic agent [198]. A previous study demonstrated promising anti-proliferative activity of sulfated carrageenan obtained from the red alga Laurencia papillosa against T98G GBM cell line.…”

Section: Carrageenanmentioning

confidence: 63%

“…Co-administration of λ-carrageenan with chemotherapeutic 5-flourouracil potentiates growth inhibition in xenograft tumors S180 and H22 with cell viability of 51.73% and lead to a stronger anti-tumor effect exerted by the drug [198]. Furthermore, chemically modified derivatives obtained by sulfation, acetylation, and phosphorylation significantly increase anti-tumor activity of κ-oligo carrageenans in mice tumor xenografts S180 model.…”

Section: Carrageenanmentioning

confidence: 99%

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Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Atiq

Parhar

2020

Molecules

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Clinically, gliomas are classified into four grades, with grade IV glioblastoma multiforme being the most malignant and deadly, which accounts for 50% of all gliomas. Characteristically, glioblastoma involves the aggressive proliferation of cells and invasion of normal brain tissue, outcomes as poor patient prognosis. With the current standard therapy of glioblastoma; surgical resection and radiotherapy followed by adjuvant chemotherapy with temozolomide, it remains fatal, because of the development of drug resistance, tumor recurrence, and metastasis. Therefore, the need for the effective therapeutic option for glioblastoma remains elusive. Previous studies have demonstrated the chemopreventive role of naturally occurring pharmacological agents through preventing or reversing the initiation phase of carcinogenesis or arresting the cancer progression phase. In this review, we discuss the role of natural phytochemicals in the amelioration of glioblastoma, with the aim to improve therapeutic outcomes, and minimize the adverse side effects to improve patient’s prognosis and enhancing their quality of life.

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Section: Carrageenanmentioning

confidence: 63%

Section: Carrageenanmentioning

confidence: 99%

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Atiq

Parhar

2020

Molecules

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“…The biological activities of carrageenan include anti-inflammatory, antitumor, antimicrobial, antioxidant, anti-hyperlipemic, anticoagulant and immunomodulatory properties. These bioactivities are dependent on the molecular weight, content and site of sulfate groups [ 55 ]. Carrageenan may be functionalized via chemical modifications to achieve improved properties.…”

Section: Biomaterials From Marine Organismsmentioning

confidence: 99%

“…κ-carrageenan possesses the highest cytotoxic effects. The 50% inhibitory concentration of κ-carrageenan is close to those antineoplastic with alkylating properties with official approval [ 55 ].…”

Section: Biomaterials From Marine Organismsmentioning

confidence: 99%

Biomaterials from the sea: Future building blocks for biomedical applications

Wan

Qin

Chen

et al. 2021

Bioactive Materials

105

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Marine resources have tremendous potential for developing high-value biomaterials. The last decade has seen an increasing number of biomaterials that originate from marine organisms. This field is rapidly evolving. Marine biomaterials experience several periods of discovery and development ranging from coralline bone graft to polysaccharide-based biomaterials. The latter are represented by chitin and chitosan, marine-derived collagen, and composites of different organisms of marine origin. The diversity of marine natural products, their properties and applications are discussed thoroughly in the present review. These materials are easily available and possess excellent biocompatibility, biodegradability and potent bioactive characteristics. Important applications of marine biomaterials include medical applications, antimicrobial agents, drug delivery agents, anticoagulants, rehabilitation of diseases such as cardiovascular diseases, bone diseases and diabetes, as well as comestible, cosmetic and industrial applications.

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“…2,33 The antioxidant effect of natural phenolic compounds has previously been studied in relation to the prevention of coronary diseases and cancer, as well as for degenerative disorders relative to the age. 34,35,36 One of essays widely used for evaluating natural antioxidants in algae or algal products is DPPH assay. DPPH• is a stable free radical that shows maximum absorbance at 517 nm.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Phytochemical Content, Antioxidant and Antibacterial Activities of Three Red Macroalgae from Algerian West Coast

2021

TJNPR

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their bioactive compounds are available in markets as anti-viral foods in assisting body's specific immune regulatory response. 12 In addition, it has been proved that applications of carrageenan gels from Chondrus crispus may block the transmission of the human immunodeficiency virus (HIV) as well as other sexually transmitted diseases (STD) viruses such as gonorrhoea, genital warts and the herpes simplex virus (HSV). 15 The red algae Chondrus crispus commonly called Irish moss or carrageen moss and Mastocarpus stellatus also called Cluimhin Cait (cats' puff), carrageen, or false Irish moss are found in the marine environment and traditionally used to cure for colds, sore throats, chest infections including tuberculosis. 16 Algeria is characterized by an extensive coastline and a phenomenal algal biodiversity. However, data on pharmacological potential of their bioactive secondary metabolites are very scarce. Hence, the current study aimed to assess the biological activity including antioxidant and antibacterial capabilities of three (03) red algae (Asparagopsis taxiformis, Hypnea musciformis and Corallina elongata) collected from Algerian West Coast (Oran). Materials and Methods Algal species collections Marine red algae were collected from Algerian West Coast (Oran) during March 2019. The algal species were identified by experts in these fields, using standard literature and taxonomic keys. The collected algal samples were cleaned well with seawater to remove impurities matter such as epiphytes, sand particles, The seaweeds were transported to the laboratory in sterile polythene bags and were washed with distilled water several times, spread on plates at room temperature and in the dark for three weeks. Dried samples were cut

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Antitumor potential of carrageenans from marine red algae

Cited by 107 publications

References 136 publications

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Anti-neoplastic Potential of Flavonoids and Polysaccharide Phytochemicals in Glioblastoma

Biomaterials from the sea: Future building blocks for biomedical applications

Phytochemical Content, Antioxidant and Antibacterial Activities of Three Red Macroalgae from Algerian West Coast

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