Antitumor Potential of Seaweed Derived-Endophytic Fungi

Teixeira, Thaiz Rodrigues; Santos, Gustavo Souza; Armstrong, Lorene; Colepicolo, Pio; Debonsi, Hosana Maria

doi:10.3390/antibiotics8040205

Cited by 33 publications

(20 citation statements)

References 111 publications

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“…They are also useful in the production of biosurfactants (Cicatiello et al, 2016;Pitocchi et al, 2020), enzymes (Nicoletti and Andolfi, 2018), and bioremediation (Bovio et al, 2017). Interestingly, endophytic fungi that are associated with macroalgae produce biologically active secondary metabolites with antibacterial, antifungal anticancer and other beneficial properties (Mathan et al, 2013;de Felício et al, 2015;Teixeira et al, 2019). Furthermore, marine fungal enzymes can be used for cleaning, textile, leather, biofuel, pulp, and paper industries; for food and beverages; for animal feed; for environmental, pharmaceutical and cosmetic applications (Bonugli-Santos et al, 2015).…”

Section: Fungimentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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Section: Fungimentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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“…The association between the host and its endophytic fungi displays symbiotic features as the endophytic inhabitant frequently gains nutrients from the host and in return strongly promotes algal growth and improves its fitness through producing definite efficient metabolites [ 42 ]. Several species of macroalgae have been tested universal in relation to their connected fungal populations, which contains different genera since the union concerning fungi and marine algae stimulates the biosynthesis of metabolites with curative possibility by these fungi [ 72 ]. Amongst these metabolites, the most frequently isolated chemical classes are peptides, polyketides, lactones, alkaloids and terpenes.…”

Section: Main Textmentioning

confidence: 99%

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

El-Bondkly

2021

Heliyon

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The growing threat arises due to diseases such as cancer and the infections around the world leading to a critical requirement for novel and constructive compounds with unique ways of action capable of combating these deadly diseases. At present, it is evident that endophytic fungi constitute an enormous as well as comparatively untapped source of great biodiversity that can be considered as a wellspring of effective novel natural products for medical, agricultural and industrial use. Marine endophytic fungi have been found in every marine plants (algae, seagrass, driftwood, mangrove plants), marine vertebrates (mainly, fish) or marine invertebrates (mainly, sponge and coral) inter- and intra-cellular without causing any palpable symptoms of illness. Since evolution of microbes and eukaryotes to a higher level, coevolution has resulted in specific interaction mechanisms. Endophytic fungi are known to influence the life cycle and are necessary for the homeostasis of their eukaryotic hosts and the chemical signals of their host have been shown to activate gene expression in endophytes to induce expression of endophytic secondary metabolites. Marine endophytic fungi are receiving increasing attention by chemists because of their varied and structurally unmatched compounds that have strong biological roles in life as lead pharmaceutical compounds, including anticancer, antiviral, insulin mimetic, antineurodegenerative, antimicrobial, antioxidant and immuno-suppressant compounds. Moreover, fungal endophytes proved to have different biological activities for exploitation in the environmental and agricultural sustainability.

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“…Fungi, which are classified as eukaryotes, are also included in microorganisms in a broad sense. In recent decades, it has been reported that microorganism-derived compounds have various bioactivities including antioxidant and antitumor effects [17,18] (Table 1). According to studies, microorganism derived compounds induced cell cycle arrest at the G2/M phase and inhibited tubulin assembly; subsequently, it triggered apoptosis in colon cancer cells [19].…”

Section: Microorganism-derived Compounds and Lymphomamentioning

confidence: 99%

Review of Natural Compounds for the Management and Prevention of Lymphoma

et al. 2020

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Lymphoma is a type of blood cancer that can be categorized into two types-Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL). A total of 509,590 and 79,990 cases of NHL and HL were newly diagnosed in 2018, respectively. Although conventional therapy has stridden forward over recent decades, its adverse effects are still a hurdle to be solved. Thus, to help researchers develop better lymphoma treatment, this study aims to review the systematic anticancer data for natural products and their compounds. A variety of natural products showed anticancerous effects on lymphoma by regulation of intracellular mechanisms including apoptosis as well as cell cycle arrest. As these results shed light on the potential to substitute conventional therapy with natural products, it may become a promising strategy for lymphoma treatment in the near future.

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Antitumor Potential of Seaweed Derived-Endophytic Fungi

Cited by 33 publications

References 111 publications

The Essentials of Marine Biotechnology

The Essentials of Marine Biotechnology

Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration

Review of Natural Compounds for the Management and Prevention of Lymphoma

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