Antitumor Properties of CLA-Enriched Food Products

Koronowicz, Aneta; Banks, Paula

doi:10.1080/01635581.2018.1460684

Cited by 18 publications

(9 citation statements)

References 88 publications

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“…Several studies were conducted to investigate the growth promoting [36], immune stimulant [37], anti-inflammatory, and anti-carcinogenic effects of CLA [38]. However, studies 1 Values are least square mean, n = 4 samples/group.…”

Section: Discussionmentioning

confidence: 99%

Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit

et al. 2020

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Conjugated linoleic acid (CLA) is known for its multiple benefits including improvement of growth, increasing lean mass, and anti-carcinogenic effects. However, when used in longterm supplementations CLA does not improve semen parameters in boar and bull and reduces fertility in Japanese quails. The content of unsaturated fatty acids in dietary lipids plays a significant role in spermatogenesis owning the high proportion of unsaturated fatty acids in plasma membrane of sperms. Whether CLA plays a role in testicular tissue and epididymal fat is still unknown. Therefore, in this study we hypothesize that long-term supplementation of equal proportion of CLA isomer mix (c9,t11-CLA and t10,c12-CLA) in rabbit bucks might alter male reproductive potentials. Twelve V-Line weaned male rabbits were used in 26 weeks trial, rabbits were individually raised and randomly allocated into three dietary groups. Control group (CON) received a basal diet, a group received 0.5% CLA (CLA 0.5%), and a group received 1% CLA (CLA 1%). Rabbits were euthanized at the end of the trial and several parameters were evaluated related to growth, semen quality, and testicular and epididymal tissue histopathology and transcriptome. The long-term supplementation of CLA increased feed intake by 5% and body weight by 2-3%. CLA 1% decreased sperm progressive motility. In testicular tissue L-carnitine and α-tocopherol were decreased by CLA supplementation. In epididymal fat, CLA tended to decrease concentration of polyunsaturated fatty acids, the expression of SCD5 gene was upregulated by CLA 1% and CASP3 gene was upregulated by CLA 0.5%. Transcription of PPARG was downregulated by CLA. Feeding 1% CLA also decreased testicular epithelial thickness. Long-term supplementation

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Section: Discussionmentioning

confidence: 99%

Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit

et al. 2020

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“…Conjugated linoleic acid (CLA) obtained from butter is the isomer of linoleic acid with conjugated double bonds. It has attracted scientific interest because of its anticancer, anti-obesity, and antiaging bioactivities [85][86][87]. CLA is naturally present in ruminant-derived products, such as milk, dairy, and beef products [87][88].…”

Section: C9 T11-conjugated Linoleic Acid (Cla)mentioning

confidence: 99%

Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review

Teibo

Ayinde

Olaoba

et al. 2021

FFHD

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The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in the treatment and restoration of normalcy in cancer patients. However, most of the therapeutic strategies employed are challenged with high cost, low efficacy, high toxicity, and multiple side effects. In recent times, emergent studies have provided evidence that functional foods and their bioactive components serve roles as potential agents in the prevention and treatment of cancers. Moreover, global interest has focused on how this chemoprevention potential of functional foods can be explored as plant-based medicines for drug development. Although, the literature is replete with the mechanism of chemoprevention elicited by individual components of functional foods, there are limited reports on their overall anti-cancer mechanisms. Therefore, this systematic review aims to unify the anti-cancer mechanisms of functional foods in cervical, breast, and liver cancers which were selected due to their high incidence and mortality globally. We reviewed articles from NCBI/PUBMED from 2010 until February 2020. Three different search words used include “Functional food and cervical cancer”; “Functional foods and breast cancer”; “Functional foods and hepatocarcinoma”. Consequently, 434 scientific papers resulted from the three search words. However, after applying the inclusion/exclusion criteria, 37 articles were selected: 14 on cervical cancer, 10 on breast cancer, and 13 on hepatocellular carcinoma. We subsequently emphasize the anti-cancer mechanisms of various functional foods in the studies selected and these include induction of apoptosis, cell cycle arrest, disruption of microtubular network, downregulation of anti-apoptotic Bcl-2 family expression, induction of autophagy, modulation of signaling cascades, ROS generation, and suppression of specific genes. Therefore, functional foods possess effective chemoprevention mechanisms which can be explored in drug development. Keywords: Cervical cancer, Breast cancer, Liver cancer, Cancer prevention, Functional foods, Bioactive compounds

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“…Conjugated linoleic acid (CLA) is the isomer of linoleic acid with conjugated double bonds. It has gained considerable attention because of its anticancer, anti‐obesity, and antiaging bioactivities (Dahiya & Puniya, ; Koronowicz & Banks, ; Wang & Wu, ). CLA is naturally present in ruminant‐derived products, such as milk, dairy, and beef products (Manzo et al, ; Verrucka, Dantasb, & Prudencio, ).…”

Section: Introductionmentioning

confidence: 99%

The dietary c 9, t 11‐conjugated linoleic acid enriched from butter reduces breast cancer progression in vivo

et al. 2020

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The c9,t11‐conjugated linoleic acid (CLA), which is the minor polyunsaturated fatty acid (PUFA) naturally present in butter, has gained attention due to its important preventive effect against breast cancer in vitro. In this paper, the enrichment of c9,t11‐CLA from butter was optimized and the preventive effect of dietary c9,t11‐CLA against breast cancer in vivo was investigated. Results showed that the concentration of c9,t11‐CLA increased more than 10 times via a one‐step urea complexation. Furthermore, the dietary c9,t11‐CLA showed obvious preventive effect against breast cancer in decreasing the tumor weight and volume, and reducing the tumor incidence up to 50%. In addition, the expression of progesterone receptor and Ki‐67 decreased significantly with the treatment of c9,t11‐CLA. In conclusion, the dietary c9,t11‐CLA enriched from butter showed a preventive effect against breast cancer in vivo via the inhibition of the hormonal receptor and cell proliferation. Practical applications This paper provided new insight into the preparation of specific c9,t11‐CLA isomer. It can be enriched from butter in large‐scale with low‐cost by urea complexation. Meanwhile, the enriched dietary c9,t11‐CLA can be further processed into cancer prevention functional foods.

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Antitumor Properties of CLA-Enriched Food Products

Cited by 18 publications

References 88 publications

Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit

Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit

Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review

The dietary c 9, t 11‐conjugated linoleic acid enriched from butter reduces breast cancer progression in vivo

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