2010
DOI: 10.1016/j.jep.2010.04.029
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Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model

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Cited by 58 publications
(62 citation statements)
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“…Anteriormente se han hecho mediciones con respecto a MT solo para evaluar parámetros oxidativos en homogenizados de tumor en el modelo Walker-256 con ratas (9) . En melanoma B16 se ha evaluado en metástasis pulmonar (8) .…”
Section: Discussionunclassified
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“…Anteriormente se han hecho mediciones con respecto a MT solo para evaluar parámetros oxidativos en homogenizados de tumor en el modelo Walker-256 con ratas (9) . En melanoma B16 se ha evaluado en metástasis pulmonar (8) .…”
Section: Discussionunclassified
“…Este extracto fue proporcionado cordialmente por Peruvian Heritage®, preparado por decocción usando etanol y agua en proporción de 70:30 por 1 h a 20 ºC y subsecuente secado por atomización, contuvo 5,03% de alcaloides oxindólicos pentacíclicos, cuantificados por cromatografía líquida de alta eficiencia (HPLC) según lo indicado por Dreifuss et al (9) . Se preparó una solución stock de UT-POA: 30 g diluidos en 1L de agua bidestilada, hervir por 30 min, decantar, filtrar dos veces en papel Whatman N.° 3 y microfiltrar (0,22 um) para esterilizar.…”
Section: Uncaria Tomentosa (Ut)unclassified
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“…Some Rubiaceae species have described biological properties, such as the species Uncaria tomentosa (Willd) D.C., popularly known as "unha-degato", being widely used in folk medicine for various indications: arthritis, asthma, cancer, gastric ulcer, inflammation and bleeding (Heitzman et al, 2005). Moreover, pharmacological studies also demonstrated that other species of this family have anti-inflammatory (Zhu et al, 2012), antinociceptive (Déciga-Campos et al, 2006), antibacterial (Comini et al, 2011), antitumor and antioxidant activities (Dreifuss et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…The effects of UT extracts on various tumor cell lines have been investigated and decreases in cell growth have been reported as a result of distinct mechanisms, including cytotoxicity and apoptotic cell death. 2,3 The anticancer properties of UT have been mainly attributed to the pentacyclic oxindole alkaloids, including speciophylline, uncarine F, mitraphylline, isomitraphylline, pteropodine, and isopteropodine, present in hydroalcoholic extracts ( Figure 1). Pilarski et al 4 evaluated the composition and antitumor activity of different UT extracts and observed that alkaloids of lower polarity (isomitraphylline, pteropodine, and isopteropodine) appeared to contribute more significantly to its anti-tumorigenic effects.…”
Section: Introductionmentioning
confidence: 99%