Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line

Silva, Emerson Lucena da; Mesquita, Felipe Pantoja; Ramos, Ingryd Nayara de Farias; Gomes, Carinne Borges de Souza Moraes Rego; Moreira, Caroline dos Santos; Ferreira, Vı́tor F.; Rocha, David R. da; Bahia, Marcelo de Oliveira; Moreira-Nunes, Caroline Aquino; Souza, Carolina Rosal Teixeira de; Burbano, Rommel Rodrı́guez; Montenegro, Raquel Carvalho

doi:10.1016/j.taap.2022.116256

Cited by 4 publications

(1 citation statement)

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“…ROS has a negative feedback action on the autophagic process: ROS can promote autophagy, and at the same time, autophagy reduces ROS production by removing damaged mitochondria, endoplasmic reticulum and other materials that contribute to ROS generation [ 56 , 57 ]. On the other hand, ROS can trigger DNA damage, initiating the apoptotic process pathway in colon cancer cells [ 58 , 59 ]. The most common method by which ROS delete transformed cells is the activation of programmed cell death, which is completed by an extrinsic or an intrinsic pathway; both pathways culminate in caspase-induced final cell demise with the formation of apoptotic bodies that are removed by adjacent phagocytes ( Figure 4 ) [ 60 ].…”

Section: Oxidative Stress and Modulation Of Autophagy And Apoptosismentioning

confidence: 99%

Different Roles of Apoptosis and Autophagy in the Development of Human Colorectal Cancer

Orlandi

Roncucci

Carnevale

et al. 2023

IJMS

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Colorectal cancer (CRC) remains a major life-threatening malignancy, despite numerous therapeutic and screening attempts. Apoptosis and autophagy are two processes that share common signaling pathways, are linked by functional relationships and have similar protein components. During the development of cancer, the two processes can trigger simultaneously in the same cell, causing, in some cases, an inhibition of autophagy by apoptosis or apoptosis by autophagy. Malignant cells that have accumulated genetic alterations can take advantage of any alterations in the apoptotic process and as a result, progress easily in the cancerous transformation. Autophagy often plays a suppressive role during the initial stages of carcinogenicity, while in the later stages of cancer development it can play a promoting role. It is extremely important to determine the regulation of this duality of autophagy in the development of CRC and to identify the molecules involved, as well as the signals and the mechanisms behind it. All the reported experimental results indicate that, while the antagonistic effects of autophagy and apoptosis occur in an adverse environment characterized by deprivation of oxygen and nutrients, leading to the formation and development of CRC, the effects of promotion and collaboration usually involve an auxiliary role of autophagy compared to apoptosis. In this review, we elucidate the different roles of autophagy and apoptosis in human CRC development.

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