2021
DOI: 10.26650/eurjbiol.2021.1010029
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Antitumoral Properties of a Pincer-Type Isonicotinohydrazone-Hg(II) Complex

Abstract: Objective:The aim of this study was to evaluate the antitumoral properties of the novel Hg(SCN) 2 complex of a pincer-type isonicotinohyrazone ligand (PTIH). Materials and Methods:Hydrazine ligands were prepared through a Schiff base condensation between the 2-Acetylpyridine and isonicotinoyl acid hydrazide. PTIH was synthetized by a branch tube method using Hg(SCN) 2 . In vitro cell killing activity, the induction of apoptosis, the influence on motility, and the effects on mRNA expression to a motility-relate… Show more

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