Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review

Abstract

Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.

Ocoxin oral solution demonstrates antiviral properties in cellular models

“…In the present study, the potential antiviral activities of the nutritional supplements OOS and VS were investigated, demonstrating that OOS pre-treatment was able to reduce both retroviral and lentiviral infection. OOS has demonstrated its antitumoral activity in several clinical trials including hepatocellular carcinoma ( 24 ), melanoma ( 25 ), head and neck ( 26 ), prostate ( 27 ), cervical and endometrial cancer ( 28 ) among others ( 29 , 30 ), and can improve the quality of life of patients ( 3 ). On the other hand, VS is a nutritional supplement that has properties as immunomodulator and hepatoprotector ( 4 , 5 , 7 , 31 , 32 ) which have also been tested in a number of trials ( 31-33 ).…”

“…OOS and VS are formulations that include several compounds with anti-oxidant, anti-inflammatory and antiviral properties ( 3 ). These properties make those products attractive to help in fighting different diseases.…”

“…OOS and VS were provided by Catalysis S.L. Detailed description of the components of OOS has been recently reported ( 3 ) and includes plant extracts ( Glycyrrhiza glabra , Camellia sinensis and Cinnamomum verum J. Presl. extract), vitamins (ascorbic acid, pyridoxine, cyanocobalamin, folic acid and calcium pantothenate), amino acids (glycine, arginine and cysteine) and sugars (sucralose and glucosamine).…”

“…Thus, in order to be ready to fight such external offenses more efficiently, an adequately fitted immune system is absolutely needed. Ocoxin Oral Solution (OOS) and Viusid (VS) are nutritional supplements that include several plant and natural products with an ample spectrum of biological activities ( 3 , 4 ). Some of these products have antioxidant, vitaminic, or antiproliferative properties.…”

“…Some of these products have antioxidant, vitaminic, or antiproliferative properties. Moreover, several of the constituents of these nutritional supplements have been reported to stimulate the immune system ( 3 , 4 ).…”